Aberrant Spontaneous Brain Activity in Patients with Mild Cognitive Impairment and concomitant Lacunar Infarction: A Resting-State Functional MRI Study

2016 ◽  
Vol 50 (4) ◽  
pp. 1243-1254 ◽  
Author(s):  
Ling Ni ◽  
Renyuan Liu ◽  
Zhenyu Yin ◽  
Hui Zhao ◽  
Zuzana Nedelska ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Functional Mri ◽  
Resting State ◽  
Brain Activity ◽  
Lacunar Infarction ◽  
Spontaneous Brain Activity ◽  
Mri Study

IC-P-091: Aberrant brain activity in patients with mild cognitive impairment with lacunar infarction: A resting-state functional MRI study

2015 ◽  
Vol 11 (7S_Part_2) ◽  
pp. P63-P64
Author(s):  
Zuzana Nedelska ◽  
Ling Ni ◽  
Renyuan Liu ◽  
Zhenyu Yin ◽  
Hui Zhao ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Functional Mri ◽  
Resting State ◽  
Brain Activity ◽  
Lacunar Infarction ◽  
Mri Study

scholarly journals Altered Spontaneous Brain Activity in Patients with Hemifacial Spasm: A Resting-State Functional MRI Study

PLoS ONE ◽  
2015 ◽  
Vol 10 (1) ◽  
pp. e0116849 ◽  
Author(s):  
Ye Tu ◽  
Yongxu Wei ◽  
Kun Sun ◽  
Weiguo Zhao ◽  
Buwei Yu
Keyword(s):  
Functional Mri ◽  
Hemifacial Spasm ◽  
Resting State ◽  
Brain Activity ◽  
Spontaneous Brain Activity ◽  
Mri Study

scholarly journals Effects of Smoking on Regional Homogeneity in Mild Cognitive Impairment: A Resting-State Functional MRI Study

2020 ◽  
Vol 12 ◽  
Author(s):  
Tianyi Zhang ◽  
Xiao Luo ◽  
Qingze Zeng ◽  
Yanv Fu ◽  
Zheyu Li ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Functional Mri ◽  
Resting State ◽  
Brain Activity ◽  
Verbal Learning ◽  
Regional Homogeneity ◽  
Angular Gyrus ◽  
Healthy Elderly ◽  
Intrinsic Brain Activity

BackgroundSmoking is a modifiable risk factor for Alzheimer’s disease (AD). However, smoking-related effects on intrinsic brain activity in high-risk AD population are still unclear.ObjectiveWe aimed to explore differences in smoking effects on brain function between healthy elderly and amnestic mild cognitive impairment (aMCI) patients using ReHo mapping.MethodsWe identified 64 healthy elderly controls and 116 aMCI patients, including 98 non-smoking and 18 smoking aMCI. Each subject underwent structural and resting-state functional MRI scanning and neuropsychological evaluations. Regional homogeneity (ReHo) mapping was used to assess regional brain synchronization. After correction for age, gender, education, and gray matter volume, we explored the difference of ReHo among groups in a voxel-wise way based on analysis of covariance (ANCOVA), followed by post hoc two-sample analyses (p < 0.05, corrected). Further, we correlated the mean ReHo with neuropsychological scales.ResultsThree groups were well-matched in age, gender, and education. Significant ReHo differences were found among three groups, located in the left supramarginal gyrus (SMG) and left angular gyrus (AG). Specifically, non-smoking aMCI had lower ReHo in SMG and AG than smoking aMCI and controls. By contrast, smoking aMCI had greater AG ReHo than healthy controls (p < 0.05). Across groups, correlation analyses showed that left AG ReHo correlated with MMSE (r = 0.18, p = 0.015), clock drawing test (r = 0.20, p = 0.007), immediate recall (r = 0.36, p < 0.001), delayed recall (r = 0.34, p < 0.001), and auditory verbal learning test (r = 0.20, p = 0.007).ConclusionSmoking might pose compensatory or protective effects on intrinsic brain activity in aMCI patients.

Sign in / Sign up

Export Citation Format

Share Document