Olfactory Dysfunction, Olfactory Bulb Volume and Alzheimer’s Disease: Is There a Correlation? A Pilot Study1

2015 ◽  
Vol 48 (2) ◽  
pp. 395-402 ◽  
Author(s):  
Adriana Servello ◽  
Alessandra Fioretti ◽  
Gianfranco Gualdi ◽  
Claudio Di Biasi ◽  
Angelo Pittalis ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Olfactory Bulb ◽  
Olfactory Dysfunction ◽  
Olfactory Bulb Volume

scholarly journals Neurogenesis, Neurodegeneration, Interneuron Vulnerability, and Amyloid-β in the Olfactory Bulb of APP/PS1 Mouse Model of Alzheimer's Disease

2016 ◽  
Vol 10 ◽  
Author(s):  
Carlos De la Rosa-Prieto ◽  
Daniel Saiz-Sanchez ◽  
Isabel Ubeda-Banon ◽  
Alicia Flores-Cuadrado ◽  
Alino Martinez-Marcos
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Olfactory Bulb ◽  
Amyloid Β ◽  
Model Of Alzheimer’S Disease

scholarly journals Three month inhalation exposure to low-level PM2.5 induced brain toxicity in an Alzheimer’s disease mouse model

PLoS ONE ◽  
2021 ◽  
Vol 16 (8) ◽  
pp. e0254587
Author(s):  
Sheng-Han Lee ◽  
Yi-Hsuan Chen ◽  
Chu-Chun Chien ◽  
Yuan-Horng Yan ◽  
Hsin-Chang Chen ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Olfactory Bulb ◽  
Prolonged Exposure ◽  
Fine Particulate Matter ◽  
Inhalation Exposure ◽  
Neuronal Loss ◽  
Exposure Period ◽  
Epidemiological Studies ◽  
Subchronic Exposure

Although numerous epidemiological studies revealed an association between ambient fine particulate matter (PM2.5) exposure and Alzheimer’s disease (AD), the PM2.5-induced neuron toxicity and associated mechanisms were not fully elucidated. The present study assessed brain toxicity in 6-month-old female triple-transgenic AD (3xTg-AD) mice following subchronic exposure to PM2.5 via an inhalation system. The treated mice were whole-bodily and continuously exposed to real-world PM2.5 for 3 months, while the control mice inhaled filtered air. Changes in cognitive and motor functions were evaluated using the Morris Water Maze and rotarod tests. Magnetic resonance imaging analysis was used to record gross brain volume alterations, and tissue staining with hematoxylin and eosin, Nissl, and immunohistochemistry methods were used to monitor pathological changes in microstructures after PM2.5 exposure. The levels of AD-related hallmarks and the oxidative stress biomarker malondialdehyde (MDA) were assessed using Western blot analysis and liquid chromatography-mass spectrometry, respectively. Our results showed that subchronic exposure to environmental levels of PM2.5 induced obvious neuronal loss in the cortex of exposed mice, but without significant impairment of cognitive and motor function. Increased levels of phosphorylated-tau and MDA were also observed in olfactory bulb or hippocampus after PM2.5 exposure, but no amyloid pathology was detected, as reported in previous studies. These results revealed that a relatively lower level of PM2.5 subchronic exposure from the environmental atmosphere still induced certain neurodegenerative changes in the brains of AD mice, especially in the olfactory bulb, entorhinal cortex and hippocampus, which is consistent with the nasal entry and spreading route for PM exposure. Systemic factors may also contribute to the neuronal toxicity. The effects of PM2.5 after a more prolonged exposure period are needed to establish a more comprehensive picture of the PM2.5-mediated development of AD.

scholarly journals P4-238: AN INVESTIGATION ON THE CLINICAL FEATURES AND NEUROPATHOLOGICAL MECHANISM OF ALZHEIMER'S DISEASE WITH OLFACTORY DYSFUNCTION

2019 ◽  
Vol 15 ◽  
pp. P1369-P1370
Author(s):  
Teng-hong Lian ◽  
Qiu-jin Yu ◽  
Peng Guo ◽  
Du-yu Ding ◽  
Dan-ning Li ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Clinical Features ◽  
Olfactory Dysfunction

scholarly journals Olfactory dysfunction in Alzheimer’s disease Systematic review and meta-analysis

2018 ◽  
Vol 12 (2) ◽  
pp. 123-132 ◽  
Author(s):  
Maren de Moraes e Silva ◽  
Pilar Bueno Siqueira Mercer ◽  
Maria Carolina Zavagna Witt ◽  
Renata Ramina Pessoa
Keyword(s):  
Systematic Review ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Early Diagnosis ◽  
Effect Size ◽  
Meta Analysis ◽  
Olfactory Dysfunction ◽  
Diagnostic Evaluation ◽  
Olfactory Analysis ◽  
Early Diagnostic

Abstract Alzheimer’s disease (AD), a neurodegenerative condition, is one of the most prevalent kinds of dementia, whose frequency doubles for every 5 years of age in elderly. Objective: To determine the correlation between AD and olfactory alterations, identifying the most affected domains and exploring the utility of olfactory tests for complementing early diagnosis. Methods: Databases were searched using the terms “olfactory OR smell OR olfaction AND alzheimer” for articles related to the proposed theme. The selected studies were categorized and evaluated separately depending on the method of analysis of the olfactory tests: identification of odors, discrimination and recognition, and a meta-analysis was carried out. Results: Fifty-one articles were selected for analysis. The effect size for most studies was large, as were the summary values for each category of individualized olfactory analysis. Conclusion: Among the olfactory domains, except memory, identification appears to be the most altered in AD. The possibility of including tests that specifically evaluate the identification of odors as an item in early diagnostic evaluation should be explored. PROSPERO registration: CRD42018089076.

O1-03-03: Olfactory dysfunction may predict Alzheimer's disease related tau pathology in cerebrospinal fluid (CSF)

2015 ◽  
Vol 11 (7S_Part_3) ◽  
pp. P130-P130
Author(s):  
Babette L.R. Reijs ◽  
Inez H.G.B. Ramakers ◽  
Charlotte E. Teunissen ◽  
D.P. Devanand ◽  
Frans R.J. Verhey ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebrospinal Fluid ◽  
Olfactory Dysfunction ◽  
Tau Pathology

P3-047: Analysis of tau protein and amyloid-b expression in the olfactory bulb of the triple transgenic mouse model of Alzheimer's disease

2015 ◽  
Vol 11 (7S_Part_14) ◽  
pp. P636-P636
Author(s):  
Claudia Luna-Herrera ◽  
Azucena Vázquez-Aguilar ◽  
Maria del Carmen Cardenas-Aguayo ◽  
Fidel de la Cruz-López ◽  
Amparo Viramontes-Pintos ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Olfactory Bulb ◽  
Transgenic Mouse ◽  
Tau Protein ◽  
Transgenic Mouse Model ◽  
Model Of Alzheimer’S Disease ◽  
Triple Transgenic Mouse
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