scholarly journals Mortality in Mild Cognitive Impairment Varies by Subtype, Sex, and Lifestyle Factors: The Mayo Clinic Study of Aging

2015 ◽  
Vol 45 (4) ◽  
pp. 1237-1245 ◽  
Author(s):  
Maria Vassilaki ◽  
Ruth H. Cha ◽  
Jeremiah A. Aakre ◽  
Terry M. Therneau ◽  
Yonas E. Geda ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Mayo Clinic ◽  
Lifestyle Factors ◽  
Clinic Study

scholarly journals Lipidomic Network of Mild Cognitive Impairment from the Mayo Clinic Study of Aging

2021 ◽  
pp. 1-11
Author(s):  
Xuewei Wang ◽  
Hai Bui ◽  
Prashanthi Vemuri ◽  
Jonathan Graff-Radford ◽  
Clifford R. Jack Jr ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Network Analysis ◽  
Mayo Clinic ◽  
Plasma Lipids ◽  
Amyloid Β ◽  
Cognitive Status ◽  
Correlation Network ◽  
Lipid Species ◽  
Clinic Study

Background: Lipid alterations contribute to Alzheimer’s disease (AD) pathogenesis. Lipidomics studies could help systematically characterize such alterations and identify potential biomarkers. Objective: To identify lipids associated with mild cognitive impairment and amyloid-β deposition, and to examine lipid correlation patterns within phenotype groups Methods: Eighty plasma lipids were measured using mass spectrometry for 1,255 non-demented participants enrolled in the Mayo Clinic Study of Aging. Individual lipids associated with mild cognitive impairment (MCI) were first identified. Correlation network analysis was then performed to identify lipid species with stable correlations across conditions. Finally, differential correlation network analysis was used to determine lipids with altered correlations between phenotype groups, specifically cognitively unimpaired versus MCI, and with elevated brain amyloid versus without. Results: Seven lipids were associated with MCI after adjustment for age, sex, and APOE4. Lipid correlation network analysis revealed that lipids from a few species correlated well with each other, demonstrated by subnetworks of these lipids. 177 lipid pairs differently correlated between cognitively unimpaired and MCI patients, whereas 337 pairs of lipids exhibited altered correlation between patients with and without elevated brain amyloid. In particular, 51 lipid pairs showed correlation alterations by both cognitive status and brain amyloid. Interestingly, the lipids central to the network of these 51 lipid pairs were not significantly associated with either MCI or amyloid, suggesting network-based approaches could provide biological insights complementary to traditional association analyses. Conclusion: Our attempt to characterize the alterations of lipids at network-level provides additional insights beyond individual lipids, as shown by differential correlations in our study.

scholarly journals Chronic Obstructive Pulmonary Disease and Association With Mild Cognitive Impairment: The Mayo Clinic Study of Aging

2013 ◽  
Vol 88 (11) ◽  
pp. 1222-1230 ◽  
Author(s):  
Balwinder Singh ◽  
Ajay K. Parsaik ◽  
Michelle M. Mielke ◽  
Rosebud O. Roberts ◽  
Paul D. Scanlon ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Pulmonary Disease ◽  
Mayo Clinic ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Clinic Study

scholarly journals Neuropsychological subtypes of incident mild cognitive impairment in the Mayo Clinic Study of Aging

2019 ◽  
Vol 15 (7) ◽  
pp. 878-887 ◽  
Author(s):  
Mary M. Machulda ◽  
Emily S. Lundt ◽  
Sabrina M. Albertson ◽  
Walter K. Kremers ◽  
Michelle M. Mielke ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Mayo Clinic ◽  
Clinic Study

Does Progression and Mortality in Mild Cognitive Impairment Vary in Men and Women? The Mayo Clinic Study of Aging (P07.155)

Neurology ◽  
2012 ◽  
Vol 78 (Meeting Abstracts 1) ◽  
pp. P07.155-P07.155
Author(s):  
R. Roberts ◽  
Y. Geda ◽  
D. Knopman ◽  
R. Cha ◽  
V. Pankratz ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Mayo Clinic ◽  
Men And Women ◽  
Clinic Study

O4-08-04: FRAILTY AND THE RISK OF INCIDENT MILD COGNITIVE IMPAIRMENT: THE MAYO CLINIC STUDY OF AGING

2014 ◽  
Vol 10 ◽  
pp. P267-P267 ◽  
Author(s):  
Mairead M. Bartley ◽  
Teresa J.H. Christianson ◽  
Vernon Pankratz ◽  
Rosebud O. Roberts ◽  
Yonas E. Geda ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Mayo Clinic ◽  
Clinic Study

P1-208: EMPIRICAL INVESTIGATION OF FUNCTIONAL ACTIVITY IN NORMAL AGING AND MILD COGNITIVE IMPAIRMENT: THE MAYO CLINIC STUDY OF AGING

2014 ◽  
Vol 10 ◽  
pp. P379-P379
Author(s):  
Leah P. Cerhan ◽  
Jazmin I. Acosta ◽  
Janina Krell-Roesch ◽  
Rosebud O. Roberts ◽  
Mary M. Machulda ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Mayo Clinic ◽  
Functional Activity ◽  
Empirical Investigation ◽  
Normal Aging ◽  
Clinic Study
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