Neuroanatomy of Alzheimer’s Disease and Late-Life Depression: A Coordinate-Based Meta-Analysis of MRI Studies

2015 ◽  
Vol 46 (4) ◽  
pp. 963-970 ◽  
Author(s):  
Maddalena Boccia ◽  
Mauro Acierno ◽  
Laura Piccardi
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Meta Analysis ◽  
Late Life ◽  
Late Life Depression ◽  
Mri Studies

scholarly journals Late-life depression and risk of vascular dementia and Alzheimer's disease: systematic review and meta-analysis of community-based cohort studies

2013 ◽  
Vol 202 (5) ◽  
pp. 329-335 ◽  
Author(s):  
Breno S. Diniz ◽  
Meryl A. Butters ◽  
Steven M. Albert ◽  
Mary Amanda Dew ◽  
Charles F. Reynolds
Keyword(s):  
Systematic Review ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Vascular Dementia ◽  
Meta Analysis ◽  
Significant Risk ◽  
Late Life ◽  
Population Based ◽  
Late Life Depression ◽  
Increased Risk

BackgroundLate-life depression may increase the risk of incident dementia, in particular of Alzheimer's disease and vascular dementia.AimsTo conduct a systematic review and meta-analysis to evaluate the risk of incident all-cause dementia, Alzheimer's disease and vascular dementia in individuals with late-life depression in population-based prospective studies.MethodA total of 23 studies were included in the meta-analysis. We used the generic inverse variance method with a random-effects model to calculate the pooled risk of dementia, Alzheimer's disease and vascular dementia in older adults with late-life depression.ResultsLate-life depression was associated with a significant risk of all-cause dementia (1.85, 95% CI 1.67-2.04, P< 0.001), Alzheimer's disease (1.65, 95% CI 1.42-1.92, P<0.001) and vascular dementia (2.52, 95% CI 1.77-3.59, P<0.001). Subgroup analysis, based on five studies, showed that the risk of vascular dementia was significantly higher than for Alzheimer's disease (P=0.03).ConclusionsLate-life depression is associated with an increased risk for all-cause dementia, vascular dementia and Alzheimer's disease. The present results suggest that it will be valuable to design clinical trials to investigate the effect of late-life depression prevention on risk of dementia, in particular vascular dementia and Alzheimer's disease.

scholarly journals When Cognitive Decline and Depression Coexist in the Elderly: CSF Biomarkers Analysis Can Differentiate Alzheimer's Disease from Late-Life Depression

2018 ◽  
Vol 10 ◽  
Author(s):  
Claudio Liguori ◽  
Mariangela Pierantozzi ◽  
Agostino Chiaravalloti ◽  
Giulia M. Sancesario ◽  
Nicola B. Mercuri ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Decline ◽  
Late Life ◽  
The Elderly ◽  
Csf Biomarkers ◽  
Late Life Depression

Cognitive impairment in remitted late-life depression is not associated with Alzheimer's disease-related CSF biomarkers

2020 ◽  
Vol 272 ◽  
pp. 409-416
Author(s):  
Júlia C. Loureiro ◽  
Florindo Stella ◽  
Marcos V. Pais ◽  
Marcia Radanovic ◽  
Paulo R. Canineu ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Late Life ◽  
Csf Biomarkers ◽  
Late Life Depression

scholarly journals Linking Late Life Depression and Alzheimer’s Disease: Mechanisms and Resilience

2019 ◽  
Vol 6 (3) ◽  
pp. 103-112 ◽  
Author(s):  
Sara L. Weisenbach ◽  
Joseph Kim ◽  
Dustin Hammers ◽  
Kelly Konopacki ◽  
Vincent Koppelmans
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Late Life ◽  
Late Life Depression ◽  
Disease Mechanisms

scholarly journals No Association of Lower Hippocampal Volume With Alzheimer’s Disease Pathology in Late-Life Depression

2017 ◽  
Vol 174 (3) ◽  
pp. 237-245 ◽  
Author(s):  
François-Laurent De Winter ◽  
Louise Emsell ◽  
Filip Bouckaert ◽  
Lene Claes ◽  
Saurabh Jain ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Late Life ◽  
Hippocampal Volume ◽  
Late Life Depression
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