Prodromal Alzheimer's Disease Presenting as Cerebral Amyloid Angiopathy-Related Inflammation with Spontaneous Amyloid-Related Imaging Abnormalities and High Cerebrospinal Fluid Anti-Aβ Autoantibodies

2015 ◽  
Vol 45 (2) ◽  
pp. 363-367 ◽  
Author(s):  
Giorgio B. Boncoraglio ◽  
Fabrizio Piazza ◽  
Mario Savoiardo ◽  
Laura Farina ◽  
Jacopo C. DiFrancesco ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebrospinal Fluid ◽  
Cerebral Amyloid Angiopathy ◽  
Amyloid Angiopathy ◽  
Prodromal Alzheimer’S Disease ◽  
Cerebral Amyloid

scholarly journals Cerebrospinal fluid levels of the neurotrophic factor neuroleukin are increased in early Alzheimer’s disease, but not in cerebral amyloid angiopathy

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Anna M. De Kort ◽  
H. Bea Kuiperij ◽  
Daniel Alcolea ◽  
Iris Kersten ◽  
Alexandra A. M. Versleijen ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebrospinal Fluid ◽  
Cerebral Amyloid Angiopathy ◽  
Medical Center ◽  
Senile Plaques ◽  
Amyloid Β ◽  
Amyloid Angiopathy ◽  
Cerebral Amyloid ◽  
Neuro Inflammation

Abstract Background Neuroleukin (NLK) is a protein with neurotrophic properties and is present in a proportion of senile plaques and amyloid laden vessels. It has been suggested that NLK is part of a neuroprotective response to amyloid β-induced cell death. The aim of our study was to investigate the value of cerebrospinal fluid (CSF) NLK levels as a biomarker of vascular amyloid deposition in patients with cerebral amyloid angiopathy (CAA) and in patients with amnestic mild cognitive impairment (aMCI) and Alzheimer’s disease (AD). Methods CSF NLK levels were quantified by ELISA in CAA patients (n = 25) and controls (n = 27) and in two independent samples of aMCI patients, AD patients, and controls: (1) From the Radboud University Medical Center (Nijmegen), we included n = 19 aMCI patients, n = 40 AD patients, and n = 32 controls. (2) From the Hospital of Sant Pau (Barcelona), we included n = 33 aMCI patients, n = 17 AD patients, and n = 50 controls. Results CSF NLK levels were similar in CAA patients and controls (p = 0.95). However, we found an elevated CSF concentration of NLK in aMCI (p < 0.0001) and AD patients (p < 0.0001) compared to controls in both samples sets. In addition, we found a correlation of CSF NLK with CSF YKL-40 (age-adjusted-spearman-rank-coefficient = 0.82, p < 0.0001) in aMCI/AD patients, a well-known glial marker of neuro-inflammation. Conclusions We found that CSF NLK levels are elevated in aMCI and AD patients compared to controls, but are not increased in CAA patients. CSF NLK levels may be related to an increased neuroinflammatory state in early stages of AD, given its association with YKL-40.

[P1-248]: ASSOCIATIONS BETWEEN CEREBRAL AMYLOID ANGIOPATHY-RELATED MICROBLEEDS AND CEREBROSPINAL FLUID BIOMARKERS IN ALZHEIMER'S DISEASE

2017 ◽  
Vol 13 (7S_Part_7) ◽  
pp. P342-P342
Author(s):  
Moeko Shinohara ◽  
Junji Komatsu ◽  
Miharu Samuraki ◽  
Ichiro Matsunari ◽  
Tokuhei Ikeda ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebrospinal Fluid ◽  
Cerebral Amyloid Angiopathy ◽  
Amyloid Angiopathy ◽  
Cerebrospinal Fluid Biomarkers ◽  
Cerebral Amyloid

scholarly journals Cerebrospinal Fluid Alzheimer’s Disease Biomarkers in Cerebral Amyloid Angiopathy-Related Inflammation

2016 ◽  
Vol 50 (3) ◽  
pp. 759-764 ◽  
Author(s):  
Dimitri Renard ◽  
Anne Wacongne ◽  
Xavier Ayrignac ◽  
Mahmoud Charif ◽  
Genevieve Fourcade ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebrospinal Fluid ◽  
Cerebral Amyloid Angiopathy ◽  
Amyloid Angiopathy ◽  
Disease Biomarkers ◽  
Cerebral Amyloid

Cerebral Amyloid Angiopathy-Related Microbleeds and Cerebrospinal Fluid Biomarkers in Alzheimer’s Disease

2016 ◽  
Vol 55 (3) ◽  
pp. 905-913 ◽  
Author(s):  
Moeko Noguchi-Shinohara ◽  
Junji Komatsu ◽  
Miharu Samuraki ◽  
Ichiro Matsunari ◽  
Tokuhei Ikeda ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebrospinal Fluid ◽  
Cerebral Amyloid Angiopathy ◽  
Amyloid Angiopathy ◽  
Cerebrospinal Fluid Biomarkers ◽  
Cerebral Amyloid

scholarly journals Normal cerebrospinal fluid concentrations of PDGFRβ in patients with cerebral amyloid angiopathy and Alzheimer's disease

2021 ◽  
Author(s):  
Anna M. De Kort ◽  
H. Bea Kuiperij ◽  
Iris Kersten ◽  
Alexandra A.M. Versleijen ◽  
Floris H.B.M. Schreuder ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebrospinal Fluid ◽  
Cerebral Amyloid Angiopathy ◽  
Amyloid Angiopathy ◽  
Cerebral Amyloid

[ 18 F]FDG PET may differentiate cerebral amyloid angiopathy from Alzheimer’s disease

2021 ◽  
Author(s):  
Sébastien Bergeret ◽  
Mathieu Queneau ◽  
Mathieu Rodallec ◽  
Emmanuel Curis ◽  
Julien Dumurgier ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebral Amyloid Angiopathy ◽  
Fdg Pet ◽  
Amyloid Angiopathy ◽  
Cerebral Amyloid
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