Alzheimer's Disease-Like Pattern of 18F-FDG Uptake during a Hyperglycemic State and Negative 11C-PiB Binding in a Patient with Mild Cognitive Impairment

2014 ◽  
Vol 42 (2) ◽  
pp. 385-389 ◽  
Author(s):  
Kenji Ishibashi ◽  
Yoshiharu Miura ◽  
Keiichi Oda ◽  
Kiichi Ishiwata ◽  
Kenji Ishii
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Fdg Uptake ◽  
18F Fdg

scholarly journals Analysis of the posterior cingulate cortex with [ 18 F]FDG-PET and Naa/mI in mild cognitive impairment and Alzheimer's disease: Correlations and differences between the two methods

2015 ◽  
Vol 9 (4) ◽  
pp. 385-393 ◽  
Author(s):  
Artur M.N. Coutinho ◽  
Fábio H.G. Porto ◽  
Poliana F. Zampieri ◽  
Maria C. Otaduy ◽  
Tíbor R. Perroco ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Fdg Pet ◽  
Cingulate Cortex ◽  
Posterior Cingulate Cortex ◽  
Cognitively Normal ◽  
Posterior Cingulate ◽  
18F Fdg

ABSTRACT Reduction of regional brain glucose metabolism (rBGM) measured by [18F]FDG-PET in the posterior cingulate cortex (PCC) has been associated with a higher conversion rate from mild cognitive impairment (MCI) to Alzheimer's disease (AD). Magnetic Resonance Spectroscopy (MRS) is a potential biomarker that has disclosed Naa/mI reductions within the PCC in both MCI and AD. Studies investigating the relationships between the two modalities are scarce. OBJECTIVE To evaluate differences and possible correlations between the findings of rBGM and NAA/mI in the PCC of individuals with AD, MCI and of cognitively normal volunteers. METHODS Patients diagnosed with AD (N=32) or MCI (N=27) and cognitively normal older adults (CG, N=28), were submitted to [18F]FDG-PET and MRS to analyze the PCC. The two methods were compared and possible correlations between the modalities were investigated. RESULTS The AD group exhibited rBGM reduction in the PCC when compared to the CG but not in the MCI group. MRS revealed lower NAA/mI values in the AD group compared to the CG but not in the MCI group. A positive correlation between rBGM and NAA/mI in the PCC was found. NAA/mI reduction in the PCC differentiated AD patients from control subjects with an area under the ROC curve of 0.70, while [18F]FDG-PET yielded a value of 0.93. CONCLUSION rBGM and Naa/mI in the PCC were positively correlated in patients with MCI and AD. [18F]FDG-PET had greater accuracy than MRS for discriminating AD patients from controls.

P2-023: MILD COGNITIVE IMPAIRMENT WITH A HIGH RISK OF PROGRESSION TO ALZHEIMER'S DISEASE DEMENTIA (MCI-HR-AD): EFFECT OF SOUVENAID® TREATMENT ON COGNITION AND 18F-FDG PET SCANS

2006 ◽  
Vol 14 (7S_Part_12) ◽  
pp. P674-P675
Author(s):  
Maria Sagrario Manzano Palomo ◽  
Belen Anaya Caravaca ◽  
Maria Angeles Balsa Breton ◽  
Sergio Muñiz Castrillo ◽  
Maria Asuncion De La Morena Vicente ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
High Risk ◽  
Fdg Pet ◽  
Risk Of Progression ◽  
18F Fdg ◽  
Pet Scans ◽  
Alzheimer’S Disease Dementia

scholarly journals Hippocampal glucose uptake as a surrogate of metabolic change of microglia in Alzheimer’s disease

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Hongyoon Choi ◽  
Yoori Choi ◽  
Eun Ji Lee ◽  
Hyun Kim ◽  
Youngsun Lee ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Glucose Metabolism ◽  
Fdg Pet ◽  
Imaging Study ◽  
Wild Type ◽  
Fdg Uptake ◽  
Soluble Trem2

Abstract Background Dynamically altered microglia play an important role in the progression of Alzheimer’s disease (AD). Here, we found a close association of the metabolic reconfiguration of microglia with increased hippocampal glucose uptake on [18F]fluorodeoxyglucose (FDG) PET. Methods We used an AD animal model, 5xFAD, to analyze hippocampal glucose metabolism using both animal FDG PET and ex vivo FDG uptake test. Cells of the hippocampus were isolated to perform single-cell RNA-sequencing (scRNA-seq). The molecular features of cells associated with glucose metabolism were analyzed at a single-cell level. In order to apply our findings to human brain imaging study, brain FDG PET data obtained from the Alzheimer’s Disease Neuroimaging Initiative were analyzed. FDG uptake in the hippocampus was compared according to the diagnosis, AD, mild cognitive impairment, and controls. The correlation analysis between hippocampal FDG uptake and soluble TREM2 in cerebrospinal fluid was performed. Results In the animal study, 8- and 12-month-old 5xFAD mice showed higher FDG uptake in the hippocampus than wild-type mice. Cellular FDG uptake tests showed that FDG activity in hippocampal microglia was increased in the AD model, while FDG activity in non-microglial cells of the hippocampus was not different between the AD model and wild-type. scRNA-seq data showed that changes in glucose metabolism signatures including glucose transporters, glycolysis and oxidative phosphorylation, mainly occurred in microglia. A subset of microglia with higher glucose transporters with defective glycolysis and oxidative phosphorylation was increased according to disease progression. In the human imaging study, we found a positive association between soluble TREM2 and hippocampal FDG uptake. FDG uptake in the hippocampus at the baseline scan predicted mild cognitive impairment conversion to AD. Conclusions We identified the reconfiguration of microglial glucose metabolism in the hippocampus of AD, which could be evaluated by FDG PET as a feasible surrogate imaging biomarker for microglia-mediated inflammation.

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