scholarly journals Increased Hippocampal Blood Flow in Sedentary Older Adults at Genetic Risk for Alzheimer's Disease

2014 ◽  
Vol 41 (3) ◽  
pp. 809-817 ◽  
Author(s):  
Zvinka Z. Zlatar ◽  
Christina E. Wierenga ◽  
Katherine J. Bangen ◽  
Thomas T. Liu ◽  
Amy J. Jak
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
Blood Flow ◽  
Genetic Risk

scholarly journals 1152 Genetic Risk Of Alzheimer’S Disease Is Linked To Short Sleep Duration

SLEEP ◽  
2020 ◽  
Vol 43 (Supplement_1) ◽  
pp. A439-A439
Author(s):  
Y Leng ◽  
K Yaffe ◽  
S Ackley ◽  
M Glymour ◽  
W Brenowitz
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
Sleep Duration ◽  
Genetic Risk ◽  
Genetic Risk Score ◽  
Genetic Ancestry ◽  
European Ancestry ◽  
Short Sleep Duration ◽  
Short Sleep

Abstract Introduction Sleep disturbances including short sleep duration are common in older adults, especially in those with Alzheimer’s disease (AD). However, it is unclear to what extent sleep duration is a manifestation of AD disease process. We examined whether genetic variants related to AD influence sleep duration in middle-aged and older adults and estimated the causal effects of AD on sleep duration using a mendelian randomization (MR) analysis. Methods We examined 406,687 UK Biobank participants with Caucasian genetic ancestry who self-reported sleep duration at baseline (2006-2010). Sleep duration was assessed by asking: “About how many hours sleep do you get in every 24 hours? (please include naps).” A genetic risk score for AD (AD-GRS) was calculated as a weighted sum of 23 previously identified AD-related single nucleotide polymorphisms in individuals of European ancestry. We evaluated whether AD-GRS predicted sleep duration using linear regression, adjusting for age, sex and principle components for genetic ancestry. We also stratified the analysis by age at baseline (≤55y or >55y) and conducted a MR analysis to estimate the effect of AD (ICD-9/10 codes for AD/dementia diagnosis) on sleep duration. Results The participants (aged 56.91±8.00y) had an average sleep duration of 7.2 (Standard deviation [SD]=1.1) hours and AD-GRS of 0.11 (SD=0.40) (range: -1.15~1.85). Higher AD-GRS score predicted shorter sleep duration (b= -0.013, 95%CI:-0.022,-0.005), mainly among those aged over 55y (b= -0.023, 95%CI:-0.034,-0.012) and not in those 55y or younger (b= 0.006, 95%CI:-0.012,0.013); p for interaction by age=0.02. MR analysis using AD-GRS as an instrumental variable suggested that AD was associated with 1.76 hrs (b=-1.76, -2.62~ -0.90) shorter sleep duration in those aged >55y. Conclusion Using a novel analytical approach, we found that higher genetic risk for AD predicted shorter sleep duration among older adults. This suggests shared genetic pathways; the biologic processes that lead to AD may also affect sleep duration. Support Dr. Leng received support from the National Institute on Aging (NIA) 1K99AG056598, and from GBHI, Alzheimer’s Association, and Alzheimer’s Society (GBHI ALZ UK-19-591141).

Fitness, Independent Of Physical Activity Is Associated With Cerebral Blood Flow In Older Adults At-risk For Alzheimer’s Disease

2017 ◽  
Vol 49 (5S) ◽  
pp. 824-825
Author(s):  
Ryan J. Dougherty ◽  
Elizabeth A. Boots ◽  
Karly A. Cody ◽  
Stephanie A. Schultz ◽  
Dorothy F. Edwards ◽  
...  
Keyword(s):  
Physical Activity ◽  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
At Risk ◽  
Blood Flow ◽  
Cerebral Blood Flow

scholarly journals Polygenic impact of common genetic risk loci for Alzheimer’s disease on cerebral blood flow in young individuals

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Hannah L. Chandler ◽  
Richard G. Wise ◽  
Kevin Murphy ◽  
Katherine E. Tansey ◽  
David E. J. Linden ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Genetic Risk

Effects of LDL Cholesterol and Statin Use on Verbal Learning and Memory in Older Adults at Genetic Risk for Alzheimer’s Disease

2020 ◽  
Vol 75 (3) ◽  
pp. 903-910
Author(s):  
Tonita Wroolie ◽  
Siena Roat-Shumway ◽  
Katie Watson ◽  
Eric Reiman ◽  
Natalie Rasgon
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
Learning And Memory ◽  
Genetic Risk ◽  
Ldl Cholesterol ◽  
Verbal Learning ◽  
Statin Use

scholarly journals Increased functional brain response during word retrieval in cognitively intact older adults at genetic risk for Alzheimer's disease

NeuroImage ◽  
2010 ◽  
Vol 51 (3) ◽  
pp. 1222-1233 ◽  
Author(s):  
Christina E. Wierenga ◽  
Nikki H. Stricker ◽  
Ashley McCauley ◽  
Alan Simmons ◽  
Amy J. Jak ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
Genetic Risk ◽  
Word Retrieval ◽  
Brain Response ◽  
Functional Brain ◽  
Cognitively Intact

Self-reference and emotional memory effects in older adults at increased genetic risk of Alzheimer’s disease

2017 ◽  
Vol 25 (2) ◽  
pp. 186-199 ◽  
Author(s):  
Matthew D. Grilli ◽  
Cindy B. Woolverton ◽  
Meli’sa Crawford ◽  
Elizabeth L. Glisky
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
Genetic Risk ◽  
Emotional Memory ◽  
Memory Effects ◽  
Self Reference

Physical activity effects on the individual alpha peak frequency of older adults with and without genetic risk factors for Alzheimer’s Disease: A MEG study

2018 ◽  
Vol 129 (9) ◽  
pp. 1981-1989 ◽  
Author(s):  
Jaisalmer de Frutos-Lucas ◽  
David López-Sanz ◽  
Pilar Zuluaga ◽  
Inmaculada Concepcion Rodríguez-Rojo ◽  
Raúl Luna ◽  
...  
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
Genetic Risk ◽  
Peak Frequency ◽  
Genetic Risk Factors ◽  
The Individual ◽  
Alpha Peak
Sign in / Sign up

Export Citation Format

Share Document