Insulin/IGF Signaling-Related Gene Expression in the Brain of a Sporadic Alzheimer's Disease Monkey Model Induced by Intracerebroventricular Injection of Streptozotocin

2013 ◽  
Vol 38 (2) ◽  
pp. 251-267 ◽  
Author(s):  
Youngjeon Lee ◽  
Young-Hyun Kim ◽  
Sang-Je Park ◽  
Jae-Won Huh ◽  
Sang-Hyun Kim ◽  
...  
Keyword(s):  
Gene Expression ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Intracerebroventricular Injection ◽  
Related Gene ◽  
Sporadic Alzheimer’S Disease ◽  
Monkey Model ◽  
The Brain ◽  
Igf Signaling

The Weak Combined Magnetic Fields Reduce the Brain β-Amyloid in an Animal Model of Sporadic Alzheimer's Disease

PIERS Online ◽  
2009 ◽  
Vol 5 (4) ◽  
pp. 311-315 ◽  
Author(s):  
Natalia V. Bobkova ◽  
Vadim V. Novikov ◽  
Natalia I. Medvinskaya ◽  
Irina Yu. Aleksandrova ◽  
Eugenii E. Fesenko
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Animal Model ◽  
Magnetic Fields ◽  
Sporadic Alzheimer’S Disease ◽  
Combined Magnetic Fields ◽  
The Brain

scholarly journals Transcriptomic analysis to identify genes associated with selective hippocampal vulnerability in Alzheimer’s disease

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Angela M. Crist ◽  
Kelly M. Hinkle ◽  
Xue Wang ◽  
Christina M. Moloney ◽  
Billie J. Matchett ◽  
...  
Keyword(s):  
Gene Expression ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Digital Pathology ◽  
Selective Vulnerability ◽  
Brain Regions ◽  
Biochemical Analyses ◽  
The Brain ◽  
Relevant Gene ◽  
Tau Expression

AbstractSelective vulnerability of different brain regions is seen in many neurodegenerative disorders. The hippocampus and cortex are selectively vulnerable in Alzheimer’s disease (AD), however the degree of involvement of the different brain regions differs among patients. We classified corticolimbic patterns of neurofibrillary tangles in postmortem tissue to capture extreme and representative phenotypes. We combined bulk RNA sequencing with digital pathology to examine hippocampal vulnerability in AD. We identified hippocampal gene expression changes associated with hippocampal vulnerability and used machine learning to identify genes that were associated with AD neuropathology, including SERPINA5, RYBP, SLC38A2, FEM1B, and PYDC1. Further histologic and biochemical analyses suggested SERPINA5 expression is associated with tau expression in the brain. Our study highlights the importance of embracing heterogeneity of the human brain in disease to identify disease-relevant gene expression.

scholarly journals Common disbalance in the brain parenchyma of dementias: Phospholipid profile analysis between CADASIL and sporadic Alzheimer's disease

2020 ◽  
Vol 1866 (8) ◽  
pp. 165797 ◽  
Author(s):  
Angélica María Sabogal-Guáqueta ◽  
Julián David Arias-Londoño ◽  
Johanna Gutierrez-Vargas ◽  
D. Sepulveda-Falla ◽  
M. Glatzel ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Profile Analysis ◽  
Brain Parenchyma ◽  
Sporadic Alzheimer’S Disease ◽  
The Brain ◽  
Phospholipid Profile

scholarly journals Conserved Architecture of Brain Transcriptome Changes between Alzheimer’s Disease and Progressive Supranuclear Palsy in Pathologically Affected and Unaffected Regions

2021 ◽  
Author(s):  
Xue Wang ◽  
Mariet Allen ◽  
Joseph S. Reddy ◽  
Minerva M. Carrasquillo ◽  
Yan W. Asmann ◽  
...  
Keyword(s):  
Gene Expression ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Progressive Supranuclear Palsy ◽  
Neurodegenerative Disorders ◽  
Transcriptomic Data ◽  
Brain Transcriptome ◽  
Transcriptional Changes ◽  
The Brain

AbstractWe identify a striking correlation in the directionality and magnitude of gene expression changes in brain transcriptomes between Alzheimer’s disease (AD) and Progressive Supranuclear Palsy (PSP). Further, the transcriptome architecture in AD and PSP is highly conserved between the temporal and cerebellar cortices, indicating highly similar transcriptional changes occur in pathologically affected and “unaffected” areas of the brain. These data have broad implications for interpreting transcriptomic data in neurodegenerative disorders.

Sign in / Sign up

Export Citation Format

Share Document