Associations between Magnetic Resonance Imaging Measures and Neuropsychological Impairment in Early and Late Onset Alzheimer's Disease

2013 ◽  
Vol 35 (1) ◽  
pp. 169-178 ◽  
Author(s):  
Annelies E. van der Vlies ◽  
Salka S. Staekenborg ◽  
Faiza Admiraal-Behloul ◽  
Niels D. Prins ◽  
Frederik Barkhof ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Magnetic Resonance ◽  
Late Onset ◽  
Neuropsychological Impairment ◽  
Resonance Imaging

Magnetic resonance imaging correlates of depression in early- and late-onset Alzheimer’s disease

1998 ◽  
Vol 44 (7) ◽  
pp. 592-599 ◽  
Author(s):  
Laura M Clark ◽  
William M McDonald ◽  
Kathleen A Welsh-Bohmer ◽  
Ilene C Siegler ◽  
Deborah V Dawson ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Magnetic Resonance ◽  
Late Onset ◽  
Resonance Imaging

scholarly journals Effects of Alzheimer’s and Vascular Pathologies on Structural Connectivity in Early- and Late-Onset Alzheimer’s Disease

2021 ◽  
Vol 15 ◽  
Author(s):  
Wha Jin Lee ◽  
Cindy W. Yoon ◽  
Sung-Woo Kim ◽  
Hye Jin Jeong ◽  
Seongho Seo ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
White Matter ◽  
Magnetic Resonance ◽  
White Matter Hyperintensities ◽  
Late Onset ◽  
Structural Connectivity ◽  
Resonance Imaging ◽  
White Matter Connectivity

Early- and late-onset Alzheimer’s disease (AD) patients often exhibit distinct features. We sought to compare overall white matter connectivity and evaluate the pathological factors (amyloid, tau, and vascular pathologies) that affect the disruption of connectivity in these two groups. A total of 50 early- and 38 late-onset AD patients, as well as age-matched cognitively normal participants, were enrolled and underwent diffusion-weighted magnetic resonance imaging to construct fractional anisotropy-weighted white matter connectivity maps. [18F]-THK5351 PET, [18F]-Flutemetamol PET, and magnetic resonance imaging were used for the evaluation of tau and related astrogliosis, amyloid, and small vessel disease markers (lacunes and white matter hyperintensities). Cluster-based statistics was performed for connectivity comparisons and correlation analysis between connectivity disruption and the pathological markers. Both patient groups exhibited significantly disrupted connectivity compared to their control counterparts with distinct patterns. Only THK retention was related to connectivity disruption in early-onset AD patients, and this disruption showed correlations with most cognitive scores, while late-onset AD patients had disrupted connectivity correlated with amyloid deposition, white matter hyperintensities, and lacunes in which only a few cognitive scores showed associations. These findings suggest that the pathogenesis of connectivity disruption and its effects on cognition are distinct between EOAD and LOAD.

Prevalence of Sinusitis Detected by Magnetic Resonance Imaging in Subjects with Dementia or Alzheimer’s Disease

2015 ◽  
Vol 12 (10) ◽  
pp. 1006-1011 ◽  
Author(s):  
Minori Yasue ◽  
Saiko Sugiura ◽  
Yasue Uchida ◽  
Hironao Otake ◽  
Masaaki Teranishi ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Magnetic Resonance ◽  
Resonance Imaging

scholarly journals Quantitative sodium imaging using ultra‐high field magnetic resonance imaging in patients with Alzheimer's disease

2020 ◽  
Vol 16 (S5) ◽  
Author(s):  
Alexa Haeger ◽  
Arthur Coste ◽  
Cécile Lerman‐Rabrait ◽  
Julien Lagarde ◽  
Jörg B. Schulz ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Magnetic Resonance ◽  
High Field ◽  
Resonance Imaging ◽  
Ultra High Field ◽  
Sodium Imaging
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