Caffeine Consumption Prevents Memory Impairment, Neuronal Damage, and Adenosine A2A Receptors Upregulation in the Hippocampus of a Rat Model of Sporadic Dementia

2013 ◽  
Vol 34 (2) ◽  
pp. 509-518 ◽  
Author(s):  
Janaína Espinosa ◽  
Andreia Rocha ◽  
Fernanda Nunes ◽  
Marcelo S. Costa ◽  
Vanessa Schein ◽  
...  
Keyword(s):  
Rat Model ◽  
Memory Impairment ◽  
Neuronal Damage ◽  
Adenosine A2a Receptors ◽  
Caffeine Consumption ◽  
A2a Receptors ◽  
Adenosine A2a

scholarly journals Functional changes in postsynaptic adenosine A2A receptors during early stages of a rat model of Huntington disease

2011 ◽  
Vol 232 (1) ◽  
pp. 76-80 ◽  
Author(s):  
Marco Orrú ◽  
Janaina Menezes Zanoveli ◽  
César Quiroz ◽  
Huu Phuc Nguyen ◽  
Xavier Guitart ◽  
...  
Keyword(s):  
Rat Model ◽  
Huntington Disease ◽  
Adenosine A2a Receptors ◽  
Functional Changes ◽  
A2a Receptors ◽  
Early Stages ◽  
Adenosine A2a

Adenosine A2A receptors are involved in physical dependence and place conditioning induced by THC

2004 ◽  
Vol 20 (8) ◽  
pp. 2203-2213 ◽  
Author(s):  
Guadalupe Soria ◽  
Anna Castane ◽  
Fernando Berrendero ◽  
Catherine Ledent ◽  
Marc Parmentier ◽  
...  
Keyword(s):  
Physical Dependence ◽  
Place Conditioning ◽  
Adenosine A2a Receptors ◽  
A2a Receptors ◽  
Adenosine A2a

scholarly journals A Crucial Role for Forebrain Adenosine A2A Receptors in Amphetamine Sensitization

2004 ◽  
Vol 30 (5) ◽  
pp. 891-900 ◽  
Author(s):  
Elena Bastia ◽  
Yue-Hang Xu ◽  
Angela C Scibelli ◽  
Yuan-Ji Day ◽  
Joel Linden ◽  
...  
Keyword(s):  
Crucial Role ◽  
Adenosine A2a Receptors ◽  
A2a Receptors ◽  
Adenosine A2a ◽  
Amphetamine Sensitization

THE ROLE OF ADENOSINE A2A RECEPTORS IN THE NEUROLEPTIC-INDUCED c-Fos EXPRESSION

1998 ◽  
Vol 9 (Supplement) ◽  
pp. S93
Author(s):  
J. Wardasa ◽  
A. Pinna ◽  
A. Cozzolino ◽  
M. Morellib
Keyword(s):  
Adenosine A2a Receptors ◽  
A2a Receptors ◽  
Fos Expression ◽  
Adenosine A2a

Afferent arteriolar adenosine A2a receptors are coupled to KATP in in vitro perfused hydronephrotic rat kidney

1999 ◽  
Vol 277 (6) ◽  
pp. F926-F933 ◽  
Author(s):  
Lilong Tang ◽  
Michael Parker ◽  
Qing Fei ◽  
Rodger Loutzenhiser
Keyword(s):  
Rat Kidney ◽  
Afferent Arteriole ◽  
Adenosine A2a Receptors ◽  
A2a Receptors ◽  
High Affinity ◽  
Vasodilatory Response ◽  
Renal Microvasculature ◽  
Adenosine A2a ◽  
Arteriolar Vasodilation

Adenosine is known to exert dual actions on the afferent arteriole, eliciting vasoconstriction, by activating A1 receptors, and vasodilation at higher concentrations, by activating lower-affinity A2 receptors. We could demonstrate both of these known adenosine responses in the in vitro perfused hydronephrotic rat kidney. Thus, 1.0 μM adenosine elicited a transient vasoconstriction blocked by 8-cyclopentyl-1,3-dipropylxanthine (DPCPX), and 10–30 μM adenosine reversed KCl-induced vasoconstriction. However, when we examined the effects of adenosine on pressure-induced afferent arteriolar vasoconstriction, we observed a third action. In this setting, a high-affinity adenosine vasodilatory response was observed at concentrations of 10–300 nM. This response was blocked by both 4-(2-[7-amino-2-(2-furyl)[1,2,4]triazolo[2,3-a][1,3,5]triazin-5-yl-amino]ethyl)phenol (ZM-241385) and glibenclamide and was mimicked by 2-phenylaminoadenosine (CV-1808) (IC50 of 100 nM), implicating adenosine A2a receptors coupled to ATP-sensitive K channels (KATP). Like adenosine, 5′- N-ethylcarboxamidoadenosine (NECA) elicited both glibenclamide-sensitive and glibenclamide-insensitive vasodilatory responses. The order of potency for the glibenclamide-sensitive component was NECA > adenosine = CV-1808. Our findings suggest that, in addition to the previously described adenosine A1 and low-affinity A2b receptors, the renal microvasculature is also capable of expressing high-affinity adenosine A2areceptors. This renal adenosine receptor elicits afferent arteriolar vasodilation at submicromolar adenosine levels by activating KATP.

scholarly journals Forebrain Adenosine A2A Receptors Contribute to L-3,4-Dihydroxyphenylalanine-Induced Dyskinesia in Hemiparkinsonian Mice

2006 ◽  
Vol 26 (52) ◽  
pp. 13548-13555 ◽  
Author(s):  
D. Xiao ◽  
E. Bastia ◽  
Y.-H. Xu ◽  
C. L. Benn ◽  
J.-H. J. Cha ◽  
...  
Keyword(s):  
Adenosine A2a Receptors ◽  
A2a Receptors ◽  
Adenosine A2a
Sign in / Sign up

Export Citation Format

Share Document