BioVenn – an R and Python package for the comparison and visualization of biological lists using area-proportional Venn diagrams

Data Science ◽  
2021 ◽  
pp. 1-11
Author(s):  
Tim Hulsen
Keyword(s):  
R Package ◽  
Venn Diagram ◽  
Data Sets ◽  
Web Interface ◽  
Web Browser ◽  
Venn Diagrams ◽  
File Formats ◽  
Source Data ◽  
Copy And Paste ◽  
Python Package

One of the most popular methods to visualize the overlap and differences between data sets is the Venn diagram. Venn diagrams are especially useful when they are ‘area-proportional’ i.e. the sizes of the circles and the overlaps correspond to the sizes of the data sets. In 2007, the BioVenn web interface was launched, which is being used by many researchers. However, this web implementation requires users to copy and paste (or upload) lists of IDs into the web browser, which is not always convenient and makes it difficult for researchers to create Venn diagrams ‘in batch’, or to automatically update the diagram when the source data changes. This is only possible by using software such as R or Python. This paper describes the BioVenn R and Python packages, which are very easy-to-use packages that can generate accurate area-proportional Venn diagrams of two or three circles directly from lists of (biological) IDs. The only required input is two or three lists of IDs. Optional parameters include the main title, the subtitle, the printing of absolute numbers or percentages within the diagram, colors and fonts. The function can show the diagram on the screen, or it can export the diagram in one of the supported file formats. The function also returns all thirteen lists. The BioVenn R package and Python package were created for biological IDs, but they can be used for other IDs as well. Finally, BioVenn can map Affymetrix and EntrezGene to Ensembl IDs. The BioVenn R package is available in the CRAN repository, and can be installed by running ‘install.packages(“BioVenn”)’. The BioVenn Python package is available in the PyPI repository, and can be installed by running ‘pip install BioVenn’. The BioVenn web interface remains available at https://www.biovenn.nl.

scholarly journals ggVennDiagram: An Intuitive, Easy-to-Use, and Highly Customizable R Package to Generate Venn Diagram

2021 ◽  
Vol 12 ◽  
Author(s):  
Chun-Hui Gao ◽  
Guangchuang Yu ◽  
Peng Cai
Keyword(s):  
Open Source ◽  
Open Source Software ◽  
Source Code ◽  
R Package ◽  
Venn Diagram ◽  
Free Access ◽  
High Quality ◽  
Venn Diagrams ◽  
Label Edge ◽  
The Cost

Venn diagrams are widely used diagrams to show the set relationships in biomedical studies. In this study, we developed ggVennDiagram, an R package that could automatically generate high-quality Venn diagrams with two to seven sets. The ggVennDiagram is built based on ggplot2, and it integrates the advantages of existing packages, such as venn, RVenn, VennDiagram, and sf. Satisfactory results can be obtained with minimal configurations. Furthermore, we designed comprehensive objects to store the entire data of the Venn diagram, which allowed free access to both intersection values and Venn plot sub-elements, such as set label/edge and region label/filling. Therefore, high customization of every Venn plot sub-element can be fulfilled without increasing the cost of learning when the user is familiar with ggplot2 methods. To date, ggVennDiagram has been cited in more than 10 publications, and its source code repository has been starred by more than 140 GitHub users, suggesting a great potential in applications. The package is an open-source software released under the GPL-3 license, and it is freely available through CRAN (https://cran.r-project.org/package=ggVennDiagram).

scholarly journals MUREN: a robust and multi-reference approach of RNA-seq transcript normalization

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Yance Feng ◽  
Lei M. Li
Keyword(s):  
Biological Significance ◽  
Housekeeping Genes ◽  
R Package ◽  
Data Sets ◽  
Statistical Regression ◽  
Rna Seq ◽  
Least Trimmed Squares ◽  
Standard Data ◽  
Wide Range ◽  
Multiple References

Abstract Background Normalization of RNA-seq data aims at identifying biological expression differentiation between samples by removing the effects of unwanted confounding factors. Explicitly or implicitly, the justification of normalization requires a set of housekeeping genes. However, the existence of housekeeping genes common for a very large collection of samples, especially under a wide range of conditions, is questionable. Results We propose to carry out pairwise normalization with respect to multiple references, selected from representative samples. Then the pairwise intermediates are integrated based on a linear model that adjusts the reference effects. Motivated by the notion of housekeeping genes and their statistical counterparts, we adopt the robust least trimmed squares regression in pairwise normalization. The proposed method (MUREN) is compared with other existing tools on some standard data sets. The goodness of normalization emphasizes on preserving possible asymmetric differentiation, whose biological significance is exemplified by a single cell data of cell cycle. MUREN is implemented as an R package. The code under license GPL-3 is available on the github platform: github.com/hippo-yf/MUREN and on the conda platform: anaconda.org/hippo-yf/r-muren. Conclusions MUREN performs the RNA-seq normalization using a two-step statistical regression induced from a general principle. We propose that the densities of pairwise differentiations are used to evaluate the goodness of normalization. MUREN adjusts the mode of differentiation toward zero while preserving the skewness due to biological asymmetric differentiation. Moreover, by robustly integrating pre-normalized counts with respect to multiple references, MUREN is immune to individual outlier samples.

scholarly journals Getting Started Creating Data Dictionaries: How to Create a Shareable Data Set

2021 ◽  
Vol 4 (1) ◽  
pp. 251524592092800
Author(s):  
Erin M. Buchanan ◽  
Sarah E. Crain ◽  
Ari L. Cunningham ◽  
Hannah R. Johnson ◽  
Hannah Stash ◽  
...  
Keyword(s):  
Data Collection ◽  
Data Sharing ◽  
Search Engine ◽  
Web Applications ◽  
Data Sets ◽  
Data Dictionary ◽  
Data Set ◽  
Entire Process ◽  
Shared Data ◽  
Source Data

As researchers embrace open and transparent data sharing, they will need to provide information about their data that effectively helps others understand their data sets’ contents. Without proper documentation, data stored in online repositories such as OSF will often be rendered unfindable and unreadable by other researchers and indexing search engines. Data dictionaries and codebooks provide a wealth of information about variables, data collection, and other important facets of a data set. This information, called metadata, provides key insights into how the data might be further used in research and facilitates search-engine indexing to reach a broader audience of interested parties. This Tutorial first explains terminology and standards relevant to data dictionaries and codebooks. Accompanying information on OSF presents a guided workflow of the entire process from source data (e.g., survey answers on Qualtrics) to an openly shared data set accompanied by a data dictionary or codebook that follows an agreed-upon standard. Finally, we discuss freely available Web applications to assist this process of ensuring that psychology data are findable, accessible, interoperable, and reusable.

scholarly journals FORESEE: a tool for the systematic comparison of translational drug response modeling pipelines

2018 ◽  
Author(s):  
Lisa-Katrin Turnhoff ◽  
Ali Hadizadeh Esfahani ◽  
Maryam Montazeri ◽  
Nina Kusch ◽  
Andreas Schuppert
Keyword(s):  
Drug Response ◽  
Drug Efficacy ◽  
Response Prediction ◽  
R Package ◽  
Supplementary Information ◽  
Supplementary File ◽  
Data Sets ◽  
Training Algorithms ◽  
Model Training

Translational models that utilize omics data generated in in vitro studies to predict the drug efficacy of anti-cancer compounds in patients are highly distinct, which complicates the benchmarking process for new computational approaches. In reaction to this, we introduce the uniFied translatiOnal dRug rESponsE prEdiction platform FORESEE, an open-source R-package. FORESEE not only provides a uniform data format for public cell line and patient data sets, but also establishes a standardized environment for drug response prediction pipelines, incorporating various state-of-the-art preprocessing methods, model training algorithms and validation techniques. The modular implementation of individual elements of the pipeline facilitates a straightforward development of combinatorial models, which can be used to re-evaluate and improve already existing pipelines as well as to develop new ones. Availability and Implementation: FORESEE is licensed under GNU General Public License v3.0 and available at https://github.com/JRC-COMBINE/FORESEE . Supplementary Information: Supplementary Files 1 and 2 provide detailed descriptions of the pipeline and the data preparation process, while Supplementary File 3 presents basic use cases of the package. Contact: [email protected]

scholarly journals SpiderSeqR: an R package for crawling the web of high-throughput multi-omic data repositories for data-sets and annotation

2020 ◽  
Author(s):  
Anna M. Sozanska ◽  
Charles Fletcher ◽  
Dóra Bihary ◽  
Shamith A. Samarajiwa
Keyword(s):  
High Throughput ◽  
R Package ◽  
Data Reuse ◽  
Massively Parallel ◽  
Data Sets ◽  
Similar Data ◽  
Data Generation ◽  
Data Repositories ◽  
Public Data ◽  
Omic Data

AbstractMore than three decades ago, the microarray revolution brought about high-throughput data generation capability to biology and medicine. Subsequently, the emergence of massively parallel sequencing technologies led to many big-data initiatives such as the human genome project and the encyclopedia of DNA elements (ENCODE) project. These, in combination with cheaper, faster massively parallel DNA sequencing capabilities, have democratised multi-omic (genomic, transcriptomic, translatomic and epigenomic) data generation leading to a data deluge in bio-medicine. While some of these data-sets are trapped in inaccessible silos, the vast majority of these data-sets are stored in public data resources and controlled access data repositories, enabling their wider use (or misuse). Currently, most peer reviewed publications require the deposition of the data-set associated with a study under consideration in one of these public data repositories. However, clunky and difficult to use interfaces, subpar or incomplete annotation prevent discovering, searching and filtering of these multi-omic data and hinder their re-purposing in other use cases. In addition, the proliferation of multitude of different data repositories, with partially redundant storage of similar data are yet another obstacle to their continued usefulness. Similarly, interfaces where annotation is spread across multiple web pages, use of accession identifiers with ambiguous and multiple interpretations and lack of good curation make these data-sets difficult to use. We have produced SpiderSeqR, an R package, whose main features include the integration between NCBI GEO and SRA databases, enabling an integrated unified search of SRA and GEO data-sets and associated annotations, conversion between database accessions, as well as convenient filtering of results and saving past queries for future use. All of the above features aim to promote data reuse to facilitate making new discoveries and maximising the potential of existing data-sets.Availabilityhttps://github.com/ss-lab-cancerunit/SpiderSeqR

scholarly journals xml2jupyter: Mapping parameters between XML and Jupyter widgets

2019 ◽  
Author(s):  
Randy Heiland ◽  
Daniel Mishler ◽  
Tyler Zhang ◽  
Eric Bower ◽  
Paul Macklin
Keyword(s):  
Programming Languages ◽  
Markup Language ◽  
Command Line ◽  
Graphical Interface ◽  
Web Browser ◽  
Agent Based ◽  
Mapping Parameters ◽  
Extensible Markup ◽  
Parameter Values ◽  
Python Package

AbstractJupyter Notebooks [4, 6] provide executable documents (in a variety of programming languages) that can be run in a web browser. When a notebook contains graphical widgets, it becomes an easy-to-use graphical user interface (GUI). Many scientific simulation packages use text-based configuration files to provide parameter values and run at the command line without a graphical interface. Manually editing these files to explore how different values affect a simulation can be burdensome for technical users, and impossible to use for those with other scientific backgrounds. xml2jupyter is a Python package that addresses these scientific bottlenecks. It provides a mapping between configuration files, formatted in the Extensible Markup Language (XML), and Jupyter widgets. Widgets are automatically generated from the XML file and these can, optionally, be incorporated into a larger GUI for a simulation package, and optionally hosted on cloud resources. Users modify parameter values via the widgets, and the values are written to the XML configuration file which is input to the simulation’s command-line interface. xml2jupyter has been tested using PhysiCell [1], an open source, agent-based simulator for biology, and it is being used by students for classroom and research projects. In addition, we use xml2jupyter to help create Jupyter GUIs for PhysiCell-related applications running on nanoHUB [5].

scholarly journals The R package “eseis” – a software toolbox for environmental seismology

2018 ◽  
Vol 6 (3) ◽  
pp. 669-686 ◽  
Author(s):  
Michael Dietze
Keyword(s):  
Data Science ◽  
Earth Science ◽  
Science Research ◽  
Worked Examples ◽  
R Package ◽  
Research Field ◽  
Data Sets ◽  
Research Fields ◽  
Scientific Disciplines ◽  
Analysis Environment

Abstract. Environmental seismology is the study of the seismic signals emitted by Earth surface processes. This emerging research field is at the intersection of seismology, geomorphology, hydrology, meteorology, and further Earth science disciplines. It amalgamates a wide variety of methods from across these disciplines and ultimately fuses them in a common analysis environment. This overarching scope of environmental seismology requires a coherent yet integrative software which is accepted by many of the involved scientific disciplines. The statistic software R has gained paramount importance in the majority of data science research fields. R has well-justified advances over other mostly commercial software, which makes it the ideal language to base a comprehensive analysis toolbox on. The article introduces the avenues and needs of environmental seismology, and how these are met by the R package eseis. The conceptual structure, example data sets, and available functions are demonstrated. Worked examples illustrate possible applications of the package and in-depth descriptions of the flexible use of the functions. The package has a registered DOI, is available under the GPL licence on the Comprehensive R Archive Network (CRAN), and is maintained on GitHub.

Digital Bookstore

2021 ◽  
Vol 9 (VII) ◽  
pp. 1326-1337
Author(s):  
Amey Thakur
Keyword(s):  
Programming Languages ◽  
Web Application ◽  
Credit Card ◽  
Sql Server ◽  
Data Sets ◽  
Frequent User ◽  
Web Browser ◽  
Book Store ◽  
Different Types ◽  
Online Book

The project's main goal is to build an online book store where users can search for and buy books based on title, author, and subject. The chosen books are shown in a tabular style and the customer may buy them online using a credit card. Using this Website, the user may buy a book online rather than going to a bookshop and spending time. Many online bookstores, such as Powell's and Amazon, were created using HTML. We suggest creating a comparable website with .NET and SQL Server. An online book store is a web application that allows customers to purchase ebooks. Through a web browser the customers can search for a book by its title or author, later can add it to the shopping cart and finally purchase using a credit card transaction. The client may sign in using his login credentials, or new clients can simply open an account. Customers must submit their full name, contact details, and shipping address. The user may also provide a review of a book by rating it on a scale of one to five. The books are classified into different types depending on their subject matter, such as software, databases, English, and architecture. Customers can shop online at the Online Book Store Website using a web browser. A client may create an account, sign in, add things to his shopping basket, and buy the product using his credit card information. As opposed to a frequent user, the Administrator has more abilities. He has the ability to add, delete, and edit book details, book categories, and member information, as well as confirm a placed order. This application was created with PHP and web programming languages. The Online Book Store is built using the Master page, data sets, data grids, and user controls.

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