Lipid peroxidation and nitric oxide metabolites in sedentary subjects and sportsmen before and after a cardiopulmonary test

2013 ◽  
Vol 54 (1) ◽  
pp. 39-49 ◽  
Author(s):  
Rosalia Lo Presti ◽  
Baldassare Canino ◽  
Maria Montana ◽  
Gregorio Caimi
Keyword(s):  
Nitric Oxide ◽  
Lipid Peroxidation ◽  
Before And After ◽  
Nitric Oxide Metabolites ◽  
Sedentary Subjects

scholarly journals REACTIVE OXYGEN AND NITROGEN SPECIES ROLE IN EXPERIMENTAL PERIODONTITIS DEVELOPMENT

2018 ◽  
Author(s):  
A. Ye. Demkovych
Keyword(s):  
Nitric Oxide ◽  
Lipid Peroxidation ◽  
Blood Serum ◽  
Inflammatory Process ◽  
Reactive Oxygen ◽  
Nitrogen Species ◽  
Initial Development ◽  
Periodontal Tissues ◽  
Experimental Periodontitis ◽  
Nitric Oxide Metabolites

Introduction. Activation of lipid peroxidation is one of the trigger mechanisms of periodontium injury, which is primary caused by cellular damage. Reactive oxygen and nitrogen species (RONS) are able to cause damage to a cell as well as final products of lipid peroxidation, including unsaturated aldehydes and other metabolites. Objective. The aim of the research was to determine the role of RONS and accumulation of lipid peroxidation derivatives in initial development and formation of chronical inflammatory process in periodontium. Methods. Experimental periodontitis was modeled in animals by injection of complex mixtures of microorganisms diluted in egg protein into periodontal tissues. The results of biochemical studies of free radical processes activity in blood serum were evaluated by content of diene, triene conjugates, TBA-active products and total quantity of metabolites of nitric oxide (NO2–+NO3–), which were determined on the 7th, 14th and 30th days of the experiment. Results. Generation of active forms of oxygen is more influential, providing longevity of inflammatory process. This pays attention to typical dynamics of changes in active processes of lipid peroxidation in the development and course of experimental periodontitis. The study of inflammatory process with a bacterial-immune component in the rats’ periodontal complex proved accumulation of lipid peroxidation and nitric oxide metabolites in blood serum.Conclusions. The preservation of increased lipid peroxidation and nitric oxide metabolites in blood serum of the experimental animals with acute periodontitis conduce enhance of alteration and delayed healing that result in its sequel into chronical periodontitis.

scholarly journals Lipid Peroxidation, Nitric Oxide Metabolites, and Their Ratio in a Group of Subjects with Metabolic Syndrome

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Gregorio Caimi ◽  
Rosalia Lo Presti ◽  
Maria Montana ◽  
Davide Noto ◽  
Baldassare Canino ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Metabolic Syndrome ◽  
Lipid Peroxidation ◽  
Hdl Cholesterol ◽  
Thiobarbituric Acid ◽  
Entire Group ◽  
Inflammatory Status ◽  
Nitric Oxide Metabolites ◽  
Nitrite Nitrate ◽  
Normal Controls

Our aim was to evaluate lipid peroxidation, expressed as thiobarbituric acid-reactive substances (TBARS), nitric oxide metabolites (nitrite + nitrate) expressed asNOx, and TBARS/NOxratio in a group of subjects with metabolic syndrome (MS). In this regard we enrolled 106 subjects with MS defined according to the IDF criteria, subsequently subdivided into diabetic (DMS) and nondiabetic (NDMS) and also into subjects with a low triglycerides/HDL-cholesterol (TG/HDL-C) index or with a high TG/HDL-C index. In the entire group and in the four subgroups of MS subjects we found an increase in TBARS andNOxlevels and a decrease in TBARS/NOxratio in comparison with normal controls. Regarding all these parameters no statistical difference between DMS and NDMS was evident, but a significant increase inNOxwas present in subjects with a high TG/HDL-C index in comparison with those with a low index. In MS subjects we also found a negative correlation between TBARS/NOxratio and TG/HDL-C index. Considering the hyperactivity of the inducible NO synthase in MS, these data confirm the altered redox and inflammatory status that characterizes the MS and suggest a link between lipid peroxidation, inflammation, and insulin resistance, evaluated as TG/HDL-C index.

scholarly journals Correlation of lipid peroxidation and nitric oxide metabolites, trace elements, and antioxidant enzymes in patients with sickle cell disease

2020 ◽  
Vol 34 (7) ◽  
Author(s):  
Charles Antwi‐Boasiako ◽  
Gifty Boatemaah Dankwah ◽  
Robert Aryee ◽  
Charles Hayfron‐Benjamin ◽  
George Aboagye ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Lipid Peroxidation ◽  
Trace Elements ◽  
Antioxidant Enzymes ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Cell Disease ◽  
Nitric Oxide Metabolites

Glycine Propionyl-L-carnitine Modulates Lipid Peroxidation and Nitric Oxide in Human Subjects

2009 ◽  
Vol 79 (3) ◽  
pp. 131-141 ◽  
Author(s):  
Richard J. Bloomer ◽  
Lesley C. Tschume ◽  
Webb A. Smith
Keyword(s):  
Nitric Oxide ◽  
Lipid Peroxidation ◽  
Aerobic Exercise ◽  
Human Subjects ◽  
Blood Lipid ◽  
Lipid Profiles ◽  
Post Intervention ◽  
Double Blind ◽  
Before And After ◽  
Main Effects

Objective: To determine the efficacy of glycine propionyl-L-carnitine (GPLC) to decrease lipid peroxidation, elevate nitric oxide, and improve blood lipid profiles in human subjects. Methods: Thirty untrained, normolipidemic subjects performed eight weeks of supervised aerobic exercise while supplementing GPLC at one of two doses (1 or 3 grams daily of PLC + glycine) or placebo, following random assignment in a double-blind manner. Fasting blood samples were analyzed at rest for malondialdehyde, nitric oxide, and lipids before and after the intervention. Results: Malondialdehyde was decreased (p<0.05) from pre- to post-intervention with 1 g GPLC (1.08±0.24 vs. 0.69±0.25 µmol·L -1) and 3 g GPLC (0.94±0.18 vs. 0.66±0.17 µmol·L -1), but did not change statistically (p>0.05) with placebo (1.12±0.21 vs. 1.03±0.23 µmol·L -1). Nitric oxide was increased (p<0.05) from pre- to post-intervention with 3 g GPLC (21.34±2.27 vs. 29.46±3.61 µmol·L -1), but did not change statistically (p>0.05) with 1 g GPLC (23.22±4.13 vs. 26.24±4.32 µmol·L -1) or placebo (24.31±3.90 vs. 26.14±4.11 µmol·L -1). No main effects or interaction effects were noted for blood lipids (p>0.05). Conclusion: GPLC supplementation combined with eight weeks of aerobic exercise decreases lipid peroxidation and elevates nitric oxide, but does not further improve blood lipid profiles in normolipidemic subjects.

Erythrocyte Deformability and Nitric Oxide Metabolites in Athletes Before and After a Cardiopulmonary Test

2009 ◽  
Vol 19 (4) ◽  
pp. 306-310 ◽  
Author(s):  
Gregorio Caimi ◽  
Baldassare Canino ◽  
Gabriella Amodeo ◽  
Paolo Ingargiola ◽  
Daniela Lucido ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Erythrocyte Deformability ◽  
Before And After ◽  
Nitric Oxide Metabolites

Effects of 7 Days of Arginine-Alpha-Ketoglutarate Supplementation on Blood Flow, Plasma L-Arginine, Nitric Oxide Metabolites, and Asymmetric Dimethyl Arginine After Resistance Exercise

2011 ◽  
Vol 21 (4) ◽  
pp. 291-299 ◽  
Author(s):  
Darryn S. Willoughby ◽  
Tony Boucher ◽  
Jeremy Reid ◽  
Garson Skelton ◽  
Mandy Clark
Keyword(s):  
Nitric Oxide ◽  
Blood Flow ◽  
Resistance Exercise ◽  
Brachial Artery ◽  
Exercise Session ◽  
Artery Blood Flow ◽  
Before And After ◽  
Asymmetric Dimethyl Arginine ◽  
Nitric Oxide Metabolites ◽  
Dimethyl Arginine

Background:Arginine-alpha-ketoglutarate (AAKG) supplements are alleged to increase nitric oxide production, thereby resulting in vasodilation during resistance exercise. This study sought to determine the effects of AAKG supplementation on hemodynamics and brachial-artery blood flow and the circulating levels of L-arginine, nitric oxide metabolites (NOx; nitrate/nitrite), asymmetric dimethyl arginine (ADMA), and L-arginine:ADMA ratio after resistance exercise.Methods:Twenty-four physically active men underwent 7 days of AAKG supplementation with 12 g/day of either NO2 Platinum or placebo (PLC). Before and after supplementation, a resistance-exercise session involving the elbow flexors was performed involving 3 sets of 15 repetitions with 70–75% of 1-repetition maximum. Data were collected immediately before, immediately after (PST), and 30 min after (30PST) each exercise session. Data were analyzed with factorial ANOVA (p < .05).Results:Heart rate, blood pressure, and blood flow were increased in both groups at PST (p = .001) but not different between groups. Plasma L-arginine was increased in the NO2 group (p = .001). NOx was shown to increase in both groups at PST (p = .001) and at 30PST (p = .001) but was not different between groups. ADMA was not affected between tests (p = .26) or time points (p = .31); however, the L-arginine:ADMA ratio was increased in the NO2 group (p = .03).Conclusion:NO2 Platinum increased plasma L-arginine levels; however, the effects observed in hemodynamics, brachial-artery blood flow, and NOx can only be attributed to the resistance exercise.

scholarly journals Reduced Levels of Nitric Oxide Metabolites in Cerebrospinal Fluid Are Associated with Equine Protozoal Myeloencephalitis

2002 ◽  
Vol 9 (3) ◽  
pp. 605-610 ◽  
Author(s):  
Chinedu J. Njoku ◽  
William J. A. Saville ◽  
Stephen M. Reed ◽  
Michael J. Oglesbee ◽  
Päivi J. Rajala-Schultz ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Cerebrospinal Fluid ◽  
Natural Infection ◽  
Clinical Signs ◽  
Sarcocystis Neurona ◽  
Immune Effector ◽  
Equine Protozoal Myeloencephalitis ◽  
Clinically Normal ◽  
Before And After ◽  
Nitric Oxide Metabolites

ABSTRACT Equine protozoal myeloencephalitis (EPM) is a disease of horses that is primarily associated with infection with the apicomplexan Sarcocystis neurona. Infection with this parasite alone is not sufficient to induce the disease, and the mechanism of neuropathogenesis associated with EPM has not been reported. Nitric oxide (NO) functions as a neurotransmitter, a vasodilator, and an immune effector and is produced in response to several parasitic protozoa. The purpose of this work was to determine if the concentration of NO metabolites (NO x −) in the cerebrospinal fluid (CSF) is correlated with the development of EPM. CSF NO x − levels were measured before and after transport-stressed, acclimated, or dexamethasone-treated horses (n = 3 per group) were experimentally infected with S. neurona sporocysts. CSF NO x − levels were also compared between horses that were diagnosed with EPM after natural infection with S. neurona and horses that did not have clinical signs of disease or that showed no evidence of infection with the parasite (n = 105). Among the experimentally infected animals, the mean CSF NO x − levels of the transport-stressed group, which had the most severe clinical signs, was reduced after infection, while these values were found to increase after infection in the remaining groups that had less severe signs of EPM. Under natural conditions, horses with EPM (n = 65) had a lower mean CSF NO x − concentration than clinically normal horses with antibodies (Abs) against S. neurona (n = 15) in CSF, and horses that developed ataxia (n = 81) had a significantly lower mean CSF NO x − concentration than horses that did not have neurologic signs (n = 24). In conclusion, lower CSF NO x − levels were associated with clinical EPM, suggesting that measurement of CSF NO x − levels could improve the accuracy of diagnostic tests that are based upon detection of S. neurona-specific Abs in CSF alone and that reduced NO levels could be causatively related to the development of EPM.

Nitric Oxide Metabolites Before and After Spinal Anesthesia with Lidocaine

1998 ◽  
Vol 89 (Supplement) ◽  
pp. 1414A
Author(s):  
Ashwani K. Chhibber ◽  
Michael P. Eaton ◽  
Stewart J. Lustik ◽  
Salvatore Mauro ◽  
Jeremy Hogan
Keyword(s):  
Nitric Oxide ◽  
Spinal Anesthesia ◽  
Before And After ◽  
Nitric Oxide Metabolites
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