TTP (time to PEAK) and RBV (regional blood volume) as valuable parameters to detect early flap failure

2011 ◽  
Vol 48 (1-3) ◽  
pp. 81-94 ◽  
Author(s):  
S. Geis ◽  
L. Prantl ◽  
S. Gehmert ◽  
P. Lamby ◽  
M. Nerlich ◽  
...  
Keyword(s):  
Blood Volume ◽  
Time To Peak ◽  
Flap Failure ◽  
Regional Blood Volume

Hemophilic Bledding Evaluated by Blood Pool Scanning

1981 ◽  
Vol 45 (03) ◽  
pp. 208-210 ◽  
Author(s):  
D Green ◽  
S M Spies ◽  
N A Rana ◽  
J W Milgram ◽  
R Mintzer
Keyword(s):  
Blood Volume ◽  
Blood Pool ◽  
Invasive Technique ◽  
Scintillation Camera ◽  
Knee Prostheses ◽  
Hemophilic Patient ◽  
Chronic Arthropathy ◽  
Image Density ◽  
Regional Blood Volume

SummaryThe technique of blood pool scanning was used to examine 15 hemophilic subjects. Employing an in vivo method for erythrocyte labeling with Technetium-99 m, a dynamic perfusion sequence is obtained using a scintillation camera positioned over the area to be examined. This demonstrates the vascularity of the tissue. Subsequently, equilibrium blood pool images of the area are obtained and analyzed with a densitometer to assess relative regional blood volume. In patients who were not bleeding but had chronic arthropathy, vascularity was not increased, and the blood volume of comparable joints was similar. By contrast, marked increases in vascularity and image density were observed in studies of acutely bleeding joints. Chronic hemarthroses were associated with persistent, but less marked increases in joint perfusion. Transient increases in joint vascularity were demonstrated after insertion of knee prostheses. In a patient with a thigh hematoma, the dimensions of the hemorrhage were clearly delineated. Since only a tracer dose of nuclide is infused intravenously, there are no allergic reactions or other side effects of the procedure. Blood pool scanning is a safe, non-invasive technique that augments clinical and radiographic evaluations, and provides a new dimension in the assessment of the hemophilic patient.

scholarly journals Measurement of Blood—Brain Hexose Transport with Dynamic PET: Comparison of [18F]2-Fluoro-2-Deoxyglucose and [11C]O-Methylglucose

1989 ◽  
Vol 9 (1) ◽  
pp. 104-110 ◽  
Author(s):  
K. Herholz ◽  
K. Wienhard ◽  
U. Pietrzyk ◽  
G. Pawlik ◽  
W.-D. Heiss
Keyword(s):  
Blood Volume ◽  
Rate Constants ◽  
Regional Analysis ◽  
Close Correlation ◽  
Transport Rate ◽  
Hexose Transport ◽  
Tracer Transport ◽  
Parametric Images ◽  
Positron Emission ◽  
Regional Blood Volume

Blood-to-tissue transport of [18F]2-fluoro-2-deoxyglucose (FDG) and [11C]O-methylglucose (CMG) was compared by dynamic positron emission tomography in four patients with recent ischemic infarcts and in three patients with intracerebral tumors. Local blood volume, tracer transport from tissue to blood, and FDG phosphorylation rates were also determined. A regional analysis of parametric images showed a close correlation of FDG and CMG transport rate constants in pathological tissue. Transport rates of FDG and CMG showed correspondingly less asymmetric remote effects than FDG phosphorylation rates. Transport rate constants were consistently higher for FDG than for CMG in pathological and normal tissue, in accordance with the higher affinity of carrier enzymes to FDG. There was a significant correlation between fitted regional blood volume values and correspondence of average absolute values with both tracers. It is concluded that dynamic FDG PET for measurement of cerebral glucose metabolism is also useful to measure alterations of hexose transport and local blood volume in pathological tissue.

Heterogeneity in malignant gliomas: a magnetic resonance analysis of spatial distribution of metabolite changes and regional blood volume

2010 ◽  
Vol 103 (3) ◽  
pp. 663-672 ◽  
Author(s):  
Marlies Wagner ◽  
Reinhold Nafe ◽  
Alina Jurcoane ◽  
Ulrich Pilatus ◽  
Kea Franz ◽  
...  
Keyword(s):  
Spatial Distribution ◽  
Magnetic Resonance ◽  
Blood Volume ◽  
Malignant Gliomas ◽  
Resonance Analysis ◽  
Regional Blood Volume

scholarly journals Imaging video plethysmography shows reduced signal amplitude in glaucoma patients in the area of the microvascular tissue of the optic nerve head

2020 ◽  
Author(s):  
Ralf-Peter Tornow ◽  
Radim Kolar ◽  
Jan Odstrcilik ◽  
Ivana Labounkova ◽  
Folkert Horn
Keyword(s):  
Optic Nerve ◽  
Ocular Hypertension ◽  
Pulse Duration ◽  
Blood Volume ◽  
Optic Nerve Head ◽  
Light Absorption ◽  
Normal Subjects ◽  
Peak Amplitude ◽  
Time To Peak ◽  
Changing Light

Abstract Purpose To measure parameters of the cardiac cycle-induced pulsatile light absorption signal (plethysmography signal) of the optic nerve head (ONH) and to compare parameters between normal subjects and patients with different stages of glaucoma. Patients and methods A recently developed video ophthalmoscope was used to acquire short video sequences (10 s) of the ONH. After image registration and trend correction, the pulsatile changing light absorption at the ONH tissue (excluding large vessels) was calculated. The changing light absorption depends on the pulsatile changing blood volume. Various parameters, including peak amplitude, steepness, time-to-peak, full width at half maximum (FWHM), and pulse duration, were calculated for averaged individual pulses (heartbeats) of the plethysmography signal. This method was applied to 19 healthy control subjects and 91 subjects with ocular hypertension, as well as different stages of primary open-angle glaucoma (17 subjects with ocular hypertension, 24 with preperimetric glaucoma, and 50 with perimetric glaucoma). Results Compared to the normal subjects, significant reductions (p < 0.001) in peak amplitude and steepness were observed in the group of perimetric glaucoma patients, but no significant difference was found for time-to-peak, FWHM, and pulse duration. Peak amplitude and steepness showed high correlations with RNFL thickness (p < 0.001). Conclusions The presented low-cost video-ophthalmoscope permits measurement of the plethysmographic signal of the ONH tissue and calculation of different blood flow-related parameters. The reduced values of the amplitude and steepness parameters in perimetric glaucoma patients suggest decreased ONH perfusion and blood volume. This outcome is in agreement with results from other studies using OCT angiography and laser speckle flowgraphy, which confirm reduced capillary density in these patients. Registration site: www.clinicaltrials.gov, Trial registration number: NCT00494923

Improving MR quantification of regional blood volume with intravascularT1 contrast agents: Accuracy, precision, and water exchange

1996 ◽  
Vol 36 (6) ◽  
pp. 858-867 ◽  
Author(s):  
Kathleen M. Donahue ◽  
Robert M. Weisskoff ◽  
David A. Chesler ◽  
Kenneth K. Kwong ◽  
Alexei A. Bogdanov ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Blood Volume ◽  
Water Exchange ◽  
Regional Blood Volume ◽  
Mr Quantification

scholarly journals Mechanisms of sympathetic regulation in orthostatic intolerance

2012 ◽  
Vol 113 (10) ◽  
pp. 1659-1668 ◽  
Author(s):  
Julian M. Stewart
Keyword(s):  
Quality Of Life ◽  
Orthostatic Hypotension ◽  
Blood Volume ◽  
Orthostatic Intolerance ◽  
Daily Life ◽  
Bipedal Stance ◽  
Sympathetic Regulation ◽  
Circulatory Control ◽  
Regional Blood Volume

Sympathetic circulatory control is key to the rapid cardiovascular adjustments that occur within seconds of standing upright (orthostasis) and which are required for bipedal stance. Indeed, patients with ineffective sympathetic adrenergic vasoconstriction rapidly develop orthostatic hypotension, prohibiting effective upright activities. One speaks of orthostatic intolerance (OI) when signs, such as hypotension, and symptoms, such as lightheadedness, occur when upright and are relieved by recumbence. The experience of transient mild OI is part of daily life. However, many people experience episodic acute OI as postural faint or chronic OI in the form of orthostatic tachycardia and orthostatic hypotension that significantly reduce the quality of life. Potential mechanisms for OI are discussed including forms of sympathetic hypofunction, forms of sympathetic hyperfunction, and OI that results from regional blood volume redistribution attributable to regional adrenergic hypofunction.

Functional imaging using DCE-US: Which parameter for the early evaluation of antiangiogenetic therapies?

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. 3524-3524 ◽  
Author(s):  
N. Lassau ◽  
S. Koscielny ◽  
M. Chebil ◽  
L. Chami ◽  
R. Bendjilali ◽  
...  
Keyword(s):  
Blood Volume ◽  
Functional Imaging ◽  
Kinase Inhibitor ◽  
Mean Transit Time ◽  
High Temporal Resolution ◽  
Multikinase Inhibitor ◽  
Early Evaluation ◽  
Time To Peak ◽  
Peak Intensity ◽  
Total Curve

3524 Background: The early evaluation of anti-angiogenic treatments is a challenge in oncology. Functional imaging methods based on the measure of tumoral vascularization have been developed using different modalities (CT, MRI, US). We analyzed the response in four studies using different targeted treatments with dynamic contrast enhanced-ultrasonography (DCE-US). Seven parameters characterizing tumoral perfusion were estimated. The objective of the study was to determine which parameter is the most appropriate to confirm earlier the efficacy of treatments. Methods: A total of 823 DCE-US were performed in 117 patients included in 4 following studies (multikinase inhibitor targeting angiogenic-receptor with a cytotoxic or thyrosine-kinase inhibitor targeted angiogenic-receptor and C-kit or monoclonal antibody anti-VEGFR). Each DCE-US was performed using contrast agent (Sonovue, Bracco) with perfusion and quantification softwares (Toshiba) from raw linear data with a high temporal resolution: 4 frames per second during 3 minutes. Seven quantitative parameters of perfusion were estimated: peak intensity (PI) and area under the total curve (AUC), area under the wash-in (AUWI), area under the wash-out (AUWO), time to peak intensity, mean transit time (MTT), wash-in slope. DCE-US were performed before treatment and after D3, D 8, 15, 21 (according each study design) and every 2 months. Patients were classified in good responders and bad responders according the response (RECIST on CT-scan) after 2 cycles or 2 months. Results: Among the 7 parameters, 2 parameters related to the blood volume studies (AUC and AUWO) were always earlier significantly modified (p = 0.04 to p = 0.004). One was never modified: MTT. For the 4 others, it's depending of each study. Conclusions: DCE-US appears as a sensitive tool to evaluate tumoral response to anti-angiogenic drugs. Functional parameters related to the blood volume are more pertinent and represent a key add value to early evaluation of these therapies studies. No significant financial relationships to disclose.

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