Capillary blood flow in haematological disorders: the role of the red cell, white cell, and plasma viscosity

2016 ◽  
Vol 7 (2) ◽  
pp. 311-319
Author(s):  
J.E. Tooke ◽  
D.W. Milligan
Keyword(s):  
Blood Flow ◽  
Plasma Viscosity ◽  
Capillary Blood ◽  
White Cell ◽  
Capillary Blood Flow ◽  
Red Cell ◽  
Haematological Disorders

Maintenance of Pulsatile Lung Capillary Blood Flow: The Role of the Pulmonary Venous System

1974 ◽  
Vol 47 (5) ◽  
pp. 24P-25P
Author(s):  
B. Rajagopalan ◽  
J. Friend ◽  
T. Stallard ◽  
G. de J. Lee
Keyword(s):  
Blood Flow ◽  
Capillary Blood ◽  
Venous System ◽  
Capillary Blood Flow

Role of Nitric Oxide in the Response of Capillary Blood Flow in the Rat Tail to Body Heating

1994 ◽  
Vol 47 (2) ◽  
pp. 177-187 ◽  
Author(s):  
Yi Zhang ◽  
Daniel Richardson ◽  
Andrew McCray
Keyword(s):  
Nitric Oxide ◽  
Blood Flow ◽  
Capillary Blood ◽  
Capillary Blood Flow ◽  
Rat Tail

scholarly journals MODERN MEDICAL PROBLEMS OF MICROCIRCULATION AND HYPOXIC SYNDROME

2015 ◽  
Vol 69 (1-2) ◽  
pp. 57-63
Author(s):  
K. P. Ivanov
Keyword(s):  
Blood Flow ◽  
Capillary Blood ◽  
Capillary Blood Flow ◽  
Adaptation To Hypoxia ◽  
Medical Problems ◽  
Complete Adaptation ◽  
Capillary Circulation ◽  
First Time ◽  
The Brain

In this paper long known problems of microcirculation are shown, which were solved only during the last 40 years. They are concerned with the velocity and character of the capillary blood flow, the regulation of the capillary blood flow, the role of various vessels in the oxygen transport, the role of leukocytes in physiology and pathology of the capillary blood flow, with the special features of the function of lungs in supplying the whole organism with oxygen and with bioenergetic laws in the development of an organism adaptation to hypoxia. Here we considered a number of the most important medical problems of microcirculation and hypoxic syndrome. A relatively new factor in the capillary circulation is the fact that in the brain and heart capillaries there are sites with pO2 close to zero. They show that the capillary circulation has no central nervous regulation of the blood flow. The blood flow in these organs obeys only occasional oscillations. The new fact is that Krogh’s rule about metabolism and oxygen exchange occurring only in the capillaries is abandoned. It is shown that almost 30% of consumed oxygen is delivered to the brain via arterioles, which changes our relation to the capillary circulation as a unique mechanism of the tissue supply with oxygen. The new fact is also the mass adhesion of leukocytes to the walls of microvessels, which results in the occlusion of the vessels followed by the development of the heart and brain ischemia. It was shown for the first time that contrary to previous ideas the alveoli in the lungs are supplied with blood from a powerful network of large microvessels from 20 to 50 μm in diameter rather than from thin arterioles. They make possible the passage of 6–12 l of the blood in the norm and during stressed muscle activity — up to 18–23 l of blood per minute. The principle is substantiated that during hypoxia only normal supply of an organism with oxygen may result in a complete adaptation of an organism to the deficit of oxygen.

Lutein Complex Supplementation Increases Ocular Blood Flow Biomarkers in Healthy Subjects

2019 ◽  
Vol 89 (1-2) ◽  
pp. 5-12
Author(s):  
Alon Harris ◽  
Brent Siesky ◽  
Amelia Huang ◽  
Thai Do ◽  
Sunu Mathew ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Blood Flow ◽  
Diastolic Blood Pressure ◽  
Healthy Subjects ◽  
Ocular Blood Flow ◽  
Capillary Blood ◽  
Post Treatment ◽  
Capillary Blood Flow ◽  
Doppler Imaging ◽  
Retinal Capillary

Abstract. Introduction: To investigate the effects of a lutein complex supplementation on ocular blood flow in healthy subjects. Materials and Methods: Sixteen healthy female patients (mean age 36.8 ± 12.1 years) were enrolled in this randomized, placebo-controlled, double-blinded, two-period crossover study. Subjects received daily an oral dose of the lutein with synergistic phytochemicals complex (lutein (10 mg), ascorbic acid (500 mg), tocopherols (364 mg), carnosic acid (2.5 mg), zeaxanthin (2 mg), copper (2 mg), with synergistic effects in reducing pro-inflammatory mediators and cytokines when administered together in combination) and placebo during administration periods. Measurements were taken before and after three-week supplementation periods, with crossover visits separated by a three-week washout period. Data analysis included blood pressure, heart rate, intraocular pressure, visual acuity, contrast sensitivity detection, ocular perfusion pressure, confocal scanning laser Doppler imaging of retinal capillary blood flow, and Doppler imaging of the retrobulbar blood vessels. Results: Lutein complex supplementation produced a statistically significant increase in mean superior retinal capillary blood flow, measured in arbitrary units (60, p = 0.0466) and a decrease in the percentage of avascular area in the superior (−0.029, p = 0.0491) and inferior (−0.023, p = 0.0477) retina, as well as reduced systolic (−4.06, p = 0.0295) and diastolic (−3.69, p = 0.0441) blood pressure measured in mmHg from baseline. Data comparison between the two supplement groups revealed a significant decrease in systemic diastolic blood pressure (change from pre- to post-treatment with lutein supplement (mean (SE)): −3.69 (1.68); change from pre- to post-treatment with placebo: 0.31 (2.57); p = 0.0357) and a significant increase in the peak systolic velocity (measured in cm/sec) in the central retinal artery (change from pre- to post-treatment with lutein supplement: 0.36 (0.19); change from pre- to post-treatment with placebo: −0.33 (0.21); p = 0.0384) with lutein complex supplement; data analyses from the placebo group were all non-significant. Discussion: In healthy participants, oral administration of a lutein phytochemicals complex for three weeks produced increased ocular blood flow biomarkers within retinal vascular beds and reduced diastolic blood pressure compared to placebo.

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