Research progress of CA125 and BDNF in serum of patients with acute myocardial infarction for predicting acute heart failure

2019 ◽  
pp. 1-8
Author(s):  
Hai-Bo Wu ◽  
Kai Shao ◽  
Yun-Can Wang ◽  
Xue-Chao Wang ◽  
Hui-Liang Liu ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Acute Myocardial Infarction ◽  
Acute Heart Failure ◽  
Research Progress

scholarly journals TCT-377 Impact of New-Onset Acute Heart Failure in Patients with Acute Myocardial infarction Underwent Successful Revascularization

2012 ◽  
Vol 60 (17) ◽  
pp. B108
Author(s):  
Keun-Ho Park ◽  
Myung Ho Jeong ◽  
Youngkeun Ahn ◽  
Jong Hyun Yoo ◽  
Sang Cheol Cho ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Acute Myocardial Infarction ◽  
Acute Heart Failure ◽  
New Onset

scholarly journals HIGH ADMISSION PLASMA OSMOLALITY VALUE AS IN-HOSPITAL MAJOR ADVERSE CARDIOVASCULAR EVENTS PREDICTOR IN PATIENT WITH ACUTE MYOCARDIAL INFARCTION

2020 ◽  
Vol 7 (11) ◽  
pp. 79-85
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Acute Myocardial Infarction ◽  
Logistic Regression ◽  
Blood Glucose ◽  
Acute Heart Failure ◽  
Cardiovascular Events ◽  
Plasma Osmolality ◽  
Receiver Operating Curve ◽  
Major Adverse Cardiovascular Events

Background: Elevated blood urea nitrogen (BUN), blood glucose, and alteration sodium levels are common among patients with acute myocardial infarction (AMI). These parameters to be widely investigated to assess the prognosis in AMI patients. However, the combination of these parameters (BUN, blood glucose, and sodium) calculated by a certain formula in the form of plasma osmolality has not been widely studied to assess the prognosis of patients with acute myocardial infarction. This study aims to assess plasma osmolality in predicting hospital major adverse cardiovascular events (MACEs) among AMI patients. Methods: Data were collected from 118 consecutive patients with AMI in Cardiac Centre Haji Adam Malik General Hospital Medan. We measured admission plasma osmolality [1,86 (Na+) + BUN/2,8 + Glucose/18+9]. Then we observed in hospital Major Adverse Cardiovascular Outcomes (MACEs) which consist of cardiovascular mortality, acute heart failure, malignant arrhythmia, and cardiogenic shock. Statistical analysis was performed using mean difference, logistic regression, and receiver operating curve (ROC). Result: Among 118 patients, MACEs were observed in 49 (41.5%) patients with the most common MACEs was acute heart failure (25.4%). Bivariate analysis showed a significant relationship between the plasma osmolality and in hospital MACEs (p < 0.001). The plasma osmolality AUC prediction value was 78.9%. The optimal cut-off value was 279.9 mOsm/kg (sensitivity 81.6%; specificity 75.4%). In multivariate logistic regression analysis, the plasma osmolality was the strongest predictor with an OR value of 10.542 (95% CI 2.694-41.255; p-value <0.001). Conclusions: Among AMI patients, high plasma osmolality value (≥280 mOsm/kg) is a better predictor of in-hospital MACEs than its components separately(BUN, glucose level, sodium).

Oxidative stress and hemorheology in patients myocardial infarction with type 2 diabetes

2015 ◽  
Vol 9 (4) ◽  
pp. 0-0 ◽  
Author(s):  
Гончарова ◽  
E. Goncharova ◽  
Ойноткинова ◽  
O. Oynotkinova ◽  
Корниенко ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Myocardial Infarction ◽  
Heart Failure ◽  
Acute Myocardial Infarction ◽  
Lipid Peroxidation ◽  
Acute Heart Failure ◽  
Blood Cells ◽  
Diabetes Type 2 ◽  
Diabetes Type

This paper highlights the influence of the intensity of the oxidative stress on hemorheology parameters in complicated and uncomplicated acute myocardial infarction in patients with diabetes type 2. The study was performed by analyzing the results of examination and treatment of 66 patients, men aged 65,6 ± 5,8 years old, suffering from coronary heart disease with clinical manifestations of acute myocardial infarction and concomitant diabetes type 2. Depending on the presence of acute heart failure patients were divided into 2 groups. 1st group consisted of 34 patients with myocardial infarction without complications, Group 2 - 32 patients who have myocardial infarction complicated by acute heart failure (II-III class classification T.Killip). Condition pro- and antioxidant systems were evaluated for 3 days by determining in the blood of patients diene conjugates, malonic dialdehyde, α-tocopherol, ceruloplasmin, calculated coefficient of oxidative stress. The rheological properties blood evaluated by the blood coagulation time, the hematocrit, amount the fibrinogen in the blood, and blood plasma viscosity, red blood cells deformability index, the aggregation of red blood cells and thrombocytes. The values obtained were compared with data from 32 healthy donors. It is revealed that the development of congestive heart failure in acute myocardial infarction in patients with diabetes type 2 is accompanied by activation of lipid peroxidation (LPO) by maintaining a high level of primary lipid peroxidation products. Insufficient activity of antioxidant defense can limit oxidative processes, and leads to their further growth. The damaging effect of lipid peroxidation in the cell membranes is reflected in violation of aggregation and blood viscosity indexes.

Impact of Clinical Profile on Hospital Mortality in Patients with Acute Heart Failure and Acute Myocardial Infarction with ST-Segment Elevation

2014 ◽  
Vol 20 (8) ◽  
pp. S117
Author(s):  
Ricardo Mourilhe-Rocha ◽  
Marcelo L.S. Bandeira ◽  
Nathalia F. Araujo ◽  
Ana Rafaela M. Santos ◽  
Roberta Ribeiro ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Acute Myocardial Infarction ◽  
Hospital Mortality ◽  
Acute Heart Failure ◽  
Clinical Profile ◽  
St Segment Elevation ◽  
St Segment

Evaluation of acute myocardial infarction patients with mid-range ejection fraction after emergency percutaneous coronary intervention

2019 ◽  
Vol 95 (1125) ◽  
pp. 355-360
Author(s):  
Yufeng Jiang ◽  
Shengda Hu ◽  
Mingqiang Cao ◽  
Xiaobo Li ◽  
Jing Zhou ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Acute Myocardial Infarction ◽  
Ejection Fraction ◽  
Acute Heart Failure ◽  
Independent Risk Factor ◽  
Protective Factor ◽  
Coronary Intervention ◽  
Percutaneous Coronary ◽  
Emergency Percutaneous Coronary Intervention

BackgroundThere is currently no classification for acute myocardial infarction (AMI) according to left ventricular ejection fraction (LVEF). We aimed to perform a retrospective analysis of patients undergoing emergency percutaneous coronary intervention (PCI), comparing the clinical characteristics, in-hospital acute heart failure and all-cause death events of AMI patients with mid-range ejection fraction (mrEF), preserved ejection fraction (pEF) and reduced ejection fraction (rEF).Material and methodsTotally 1270 patients were stratified according to their LVEF immediately after emergency PCI into pEF group (LVEF 50% or higher), mrEF group (LVEF 40%–49%) and rEF group (LVEF <40%). Kaplan-Meier curves and log rank tests were used to assess the effects of mrEF, rEF and pEF on the occurrence of acute heart failure and all-cause death during hospitalisation. The Cox proportional hazards model was used for multivariate correction.ResultsCompared with mrEF, rEF was an independent risk factor for acute heart failure events during hospitalisation (HR 5.01, 95% CI 3.53 to 7.11, p<0.001), and it was also an independent risk factor for all-cause mortality during hospitalisation (HR 7.05, 95% CI 4.12 to 12.1, p<0.001); Compared with mrEF, pEF was an independent protective factor for acute heart failure during hospitalisation (HR 0.49, 95% CI 0.30 to 0.82, p=0.01), and it was also an independent protective factor for all-cause death during hospitalisation (HR 0.33, 95% CI 0.11 to 0.96, p=0.04).ConclusionsmrEF patients with AMI undergoing emergency PCI share many similarities with pEF patients in terms of clinical features, but the prognosis is significantly worse than that of pEF patients, suggesting that we need to pay attention to the management of mrEF patients with AMI.

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