Chronic intermittent hypoxia vs chronic continuous hypoxia: Effects on vascular endothelial function and myocardial contractility

2020 ◽  
Vol 74 (4) ◽  
pp. 417-427 ◽  
Author(s):  
Jing Zhu ◽  
Jing Kang ◽  
Xiaochen Li ◽  
Mengmei Wang ◽  
Min Shang ◽  
...  
Keyword(s):  
Endothelial Function ◽  
Myocardial Contractility ◽  
Intermittent Hypoxia ◽  
Chronic Intermittent Hypoxia ◽  
Vascular Endothelial ◽  
Vascular Endothelial Function

scholarly journals Chronic intermittent hypoxia accelerates coronary microcirculatory dysfunction in insulin-resistant Goto-Kakizaki rats

2016 ◽  
Vol 311 (2) ◽  
pp. R426-R439 ◽  
Author(s):  
Yi Ching Chen ◽  
Tadakatsu Inagaki ◽  
Yutaka Fujii ◽  
Daryl O. Schwenke ◽  
Hirotsugu Tsuchimochi ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Endothelial Function ◽  
Intermittent Hypoxia ◽  
Wistar Rats ◽  
Chronic Intermittent Hypoxia ◽  
Vascular Endothelial ◽  
Gk Rats ◽  
Insulin Resistant ◽  
Coronary Endothelial Function

Chronic intermittent hypoxia (IH) induces oxidative stress and inflammation, which impair vascular endothelial function. Long-term insulin resistance also leads to endothelial dysfunction. We determined, in vivo, whether the effects of chronic IH and insulin resistance on endothelial function augment each other. Male 12-wk-old Goto-Kakizaki (GK) and Wistar control rats were subjected to normoxia or chronic IH (90-s N2, 5% O2 at nadir, 90-s air, 20 cycles/h, 8 h/day) for 4 wk. Coronary endothelial function was assessed using microangiography with synchrotron radiation. Imaging was performed at baseline, during infusion of acetylcholine (ACh, 5 μg·kg−1·min−1) and then sodium nitroprusside (SNP, 5 μg·kg−1·min−1), after blockade of both nitric oxide (NO) synthase (NOS) with Nω-nitro-l-arginine methyl ester (l-NAME, 50 mg/kg) and cyclooxygenase (COX, meclofenamate, 3 mg/kg), and during subsequent ACh. In GK rats, coronary vasodilatation in response to ACh and SNP was blunted compared with Wistar rats, and responses to ACh were abolished after blockade. In Wistar rats, IH blunted the ability of ACh or SNP to increase the number of visible vessels. In GK rats exposed to IH, neither ACh nor SNP were able to increase visible vessel number or caliber, and blockade resulted in marked vasoconstriction. Our findings indicate that IH augments the deleterious effects of insulin resistance on coronary endothelial function. They appear to increase the dependence of the coronary microcirculation on NO and/or vasodilator prostanoids, and greatly blunt the residual vasodilation in response to ACh after blockade of NOS/COX, presumably mediated by endothelium-derived hyperpolarizing factors.

Albuminuria Is More Closely Associated with Vascular Endothelial Function than eGFR in Type 2 Diabetes with Diabetic Kidney Disease

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 443-P
Author(s):  
YOSHINORI KAKUTANI ◽  
MASANORI EMOTO ◽  
YUKO YAMAZAKI ◽  
KOKA MOTOYAMA ◽  
TOMOAKI MORIOKA ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Kidney Disease ◽  
Endothelial Function ◽  
Diabetic Kidney Disease ◽  
Vascular Endothelial ◽  
Vascular Endothelial Function ◽  
Diabetic Kidney

scholarly journals A novel approach to the assessment of vascular endothelial function

2011 ◽  
Vol 307 ◽  
pp. 012014 ◽  
Author(s):  
S Sathasivam ◽  
S Phababpha ◽  
P Sengmeuan ◽  
P Detchaporn ◽  
Z Siddiqui ◽  
...  
Keyword(s):  
Endothelial Function ◽  
Vascular Endothelial ◽  
Vascular Endothelial Function ◽  
Novel Approach

scholarly journals Association of Physical Activity With Vascular Endothelial Function and Intima-Media Thickness

Circulation ◽  
2011 ◽  
Vol 124 (18) ◽  
pp. 1956-1963 ◽  
Author(s):  
Katja Pahkala ◽  
Olli J. Heinonen ◽  
Olli Simell ◽  
Jorma S.A. Viikari ◽  
Tapani Rönnemaa ◽  
...  
Keyword(s):  
Physical Activity ◽  
Endothelial Function ◽  
Intima Media Thickness ◽  
Vascular Endothelial ◽  
Vascular Endothelial Function ◽  
Media Thickness

Abstract 319: Effects of Muscle Stretching on Flow-Mediated Dilation of Popliteal Artery in Patients With Peripheral Artery Disease

2017 ◽  
Vol 37 (suppl_1) ◽  
Author(s):  
Kazuki Hotta ◽  
Wayne B Batchelor ◽  
James Graven ◽  
Vishal Dahya ◽  
Thomas E Noel ◽  
...  
Keyword(s):  
Endothelial Function ◽  
Popliteal Artery ◽  
Calf Muscle ◽  
Walking Distance ◽  
Flow Mediated Dilation ◽  
Vascular Endothelial ◽  
Vascular Endothelial Function ◽  
Peripheral Artery ◽  
Muscle Stretching ◽  
Artery Disease

Patients with peripheral artery disease (PAD) frequently have walking impairment due to lower extremity claudication. Our preliminary results in a rat model of aging indicate that a program of daily calf muscle stretching improves endothelium-dependent dilation of soleus muscle arterioles and increases soleus muscle blood flow during exercise. However, the effects of muscle stretching on the function of arteries supplying the legs of PAD patients is unknown. We hypothesized that daily calf muscle stretching improves vascular endothelial function and walking distance in PAD patients. To test our hypothesis, a randomized, non-blinded, crossover study was performed. Four weeks of muscle stretching (30 min/d, 5 days/wk) and 4 weeks of sedentary lifestyle (no stretching) were performed in random order. Thirteen patients with PAD participated in this study (71 ± 2 years old; 7 males and 6 females). During the stretching intervention both ankle joints were maintained at 15o of dorsiflexion using ankle dorsiflexion splints to stretch their calf muscles at home. Flow-mediated dilation (FMD; dilation to post-occlusion reactive hyperemia) and nitroglycerin-induced dilation (dilation to sublingual 0.4 mg nitroglycerin) of the popliteal artery were measured after 4 weeks of muscle stretching and after the no stretching period using ultrasound. A six-minute walk test was also performed to obtain walking distance. After 4 weeks of muscle stretching, FMD and 6-minute walking distance significantly improved as compared to the values measured after 4 weeks of no stretching (FMD: 5.2 ± 0.6 % vs. 3.7 ± 0.4 %, P=0.003 stretching vs. no stretching, 6-minute walking distance: 355 ± 32 m vs. 311 ± 31 m, P=0.007, stretching vs. no stretching; mean ± SE). No difference in nitroglycerin-induced dilation was found between groups (10.9 ± 1.4 vs. 9.9 ± 1.1 %, P=0.54, stretching vs. no stretching). Percentage change of walking distance (%change = [(stretching - no stretching) / no stretching] x 100) significantly correlated with the %change of FMD (R 2 =0.65, P=0.03). These results indicate that static calf muscle stretching enhances vascular endothelial function of the popliteal artery, contributing to improvement of walking tolerance in PAD patients.

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