Efficacy of dynamic enhancement effects on Gd-EOB-DTPA-enhanced MRI for estimation of liver function assessed by 13C- Methacetin breath test

2019 ◽  
Vol 70 (4) ◽  
pp. 595-604
Author(s):  
Ute Probst ◽  
Dominik Sieron ◽  
Karin Bruenn ◽  
Irene Fuhrmann ◽  
Niklas Verloh ◽  
...  
Keyword(s):  
Liver Function ◽  
Breath Test ◽  
Enhanced Mri ◽  
Dynamic Enhancement

Gd-EOB-DTPA-enhanced MRI T1 relaxometry as an imaging-based liver function test compared with 13C-methacetin breath test

2019 ◽  
Vol 61 (3) ◽  
pp. 291-301 ◽  
Author(s):  
Dorothea Theilig ◽  
Ana Tsereteli ◽  
Aboelyazid Elkilany ◽  
Philip Raabe ◽  
Lutz Lüdemann ◽  
...  
Keyword(s):  
Liver Function ◽  
Liver Function Test ◽  
Breath Test ◽  
Linear Regression Analysis ◽  
Liver Volume ◽  
Reduction Rate ◽  
Multiple Linear Regression Analysis ◽  
Enhanced Mri ◽  
Function Test ◽  
T1 Relaxometry

Background Gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) can be used as an imaging-based liver function test. This study aims to further corroborate its validity. Purpose To compare Gd-EOB-DTPA-enhanced MRI as an imaging-based liver function test with the 13C-methacetin breath test. Material and Methods Fifty-three patients who underwent Gd-EOB-DTPA-enhanced MRI T1 relaxometry before and 20 min after intravenous Gd-EOB-DTPA administration as well as a 13C-methacetin breath test (LiMAx test) were retrospectively analyzed. T1 relaxation times of liver parenchyma, total liver volume (TLV), and functional liver volume (FLV) were determined. Pearson correlations, multiple linear regression analysis, and receiver operating characteristic curve analysis were performed with indices derived from T1 relaxometry, liver volumetry, and laboratory parameters to identify the best predictor of liver function as determined by the LiMAx test. Results T1 reduction rate (T1 RR), T1 RR × TLV, T1 RR × FLV, and T1 relaxation time 20 min after intravenous Gd-EOB administration showed a statistically significant correlation with LiMAx and discriminatory capacity between patients with LiMAx of > and < 315 µg/kg/h. Of the indices investigated, T1 RR showed the best discriminatory capacity and proved to be the only statistically significant parameter in multiple linear regression analysis. Conclusion Gd-EOB-DTPA-enhanced MRI as an imaging-based liver function test also correlates with the LiMAx test which in turn reflects cytochrome P450 function. The T1 reduction rate of the liver on Gd-EOB-DTPA-enhanced MRI allows prediction of liver function as determined by the LiMAx test both for 1.5 and 3.0 T.

Imaging-based evaluation of liver function: comparison of 99mTc-mebrofenin hepatobiliary scintigraphy and Gd-EOB-DTPA-enhanced MRI

2014 ◽  
Vol 25 (5) ◽  
pp. 1384-1391 ◽  
Author(s):  
Dominik Geisel ◽  
Lutz Lüdemann ◽  
Vera Fröling ◽  
Maciej Malinowski ◽  
Martin Stockmann ◽  
...  
Keyword(s):  
Liver Function ◽  
Hepatobiliary Scintigraphy ◽  
Enhanced Mri

scholarly journals Predictive value of gadoxetic acid–enhanced MRI for posthepatectomy liver failure: a systematic review

2021 ◽  
Author(s):  
Qiang Wang ◽  
Anrong Wang ◽  
Ernesto Sparrelid ◽  
Jiaxing Zhang ◽  
Ying Zhao ◽  
...  
Keyword(s):  
Systematic Review ◽  
Liver Function ◽  
Liver Failure ◽  
Risk Of Bias ◽  
Gadoxetic Acid ◽  
Imaging Biomarker ◽  
Cochrane Library ◽  
Large Sample Size ◽  
Posthepatectomy Liver Failure ◽  
Enhanced Mri

Abstract   Objectives Effective and non-invasive biomarkers to predict and avoid posthepatectomy liver failure (PHLF) are urgently needed. This systematic review aims to evaluate the efficacy of gadoxetic acid–enhanced MRI-derived parameters as an imaging biomarker in preoperative prediction of PHLF. Methods A systematic literature search was performed in the databases of PubMed/Medline, Web of Science, Embase, and Cochrane Library up to 11 December 2020. Studies evaluating the incidence of PHLF on patients who underwent hepatectomy with preoperative liver function assessment using gadoxetic acid–enhanced MRI were included. Data was extracted using pre-designed tables. The Quality In Prognostic Studies (QUIPS) tool was adopted to evaluate the risk of bias. Results A total of 15 studies were identified for qualitative synthesis and most studies were marked as low to moderate risk of bias in each domain of QUIPS. The most commonly used parameter was relative liver enhancement or its related parameters. The reported incidence of PHLF ranged from 3.9 to 40%. The predictive sensitivity and specificity of gadoxetic acid–enhanced MRI parameters varied from 75 to 100% and from 54 to 93% in ten reported studies. A majority of the studies revealed that the gadoxetic acid–enhanced MRI parameter was a predictor for PHLF. Conclusions Gadoxetic acid–enhanced MRI showed a high predictive capacity for PHLF and represents a promising imaging biomarker in prediction of PHLF. Multicenter, prospective trials with large sample size and reliable, unified liver function parameters are required to validate the efficacy of individual liver function parameters. Key Points • There is an obvious heterogeneity of the published studies, not only in variance of MRI liver function parameters but also in indication and extent of the liver resection. • Signal intensity (SI)–based parameters derived from gadoxetic acid–enhanced MRI are the commonly used method for PHLF prediction. • Gadoxetic acid–enhanced MRI-derived parameters showed high predictive efficacy for PHLF and can potentially serve as a predictor for the incidence of PHLF.

scholarly journals Microsomal Liver Function in Patients with Phenylketonuria Assessed by 13C-Methacetin Breath Test

2017 ◽  
Vol 27 (6) ◽  
Author(s):  
Renata Mozrzymas ◽  
Monika Dus-Zuchowska ◽  
Lukasz Kaluzny ◽  
Anna Miskiewicz-Chotnicka ◽  
Aleksandra Lisowska ◽  
...  
Keyword(s):  
Liver Function ◽  
Breath Test ◽  
Microsomal Liver

Gd-EOB-DTPA-enhanced T1 relaxometry for assessment of liver function determined by real-time 13C-methacetin breath test

2018 ◽  
Vol 28 (9) ◽  
pp. 3591-3600 ◽  
Author(s):  
Michael Haimerl ◽  
Irene Fuhrmann ◽  
Stefanie Poelsterl ◽  
Claudia Fellner ◽  
Marcel D. Nickel ◽  
...  
Keyword(s):  
Liver Function ◽  
Real Time ◽  
Breath Test ◽  
T1 Relaxometry

scholarly journals Quantification of liver function using gadoxetic acid-enhanced MRI

2020 ◽  
Vol 45 (11) ◽  
pp. 3532-3544
Author(s):  
Sarah Poetter-Lang ◽  
Nina Bastati ◽  
Alina Messner ◽  
Antonia Kristic ◽  
Alexander Herold ◽  
...  
Keyword(s):  
Liver Function ◽  
Liver Diseases ◽  
Organic Anion ◽  
Liver Perfusion ◽  
Dynamic Imaging ◽  
Gadoxetic Acid ◽  
Functional Evaluation ◽  
Nonalcoholic Fatty Liver ◽  
Enhanced Mri

Abstract The introduction of hepatobiliary contrast agents, most notably gadoxetic acid (GA), has expanded the role of MRI, allowing not only a morphologic but also a functional evaluation of the hepatobiliary system. The mechanism of uptake and excretion of gadoxetic acid via transporters, such as organic anion transporting polypeptides (OATP1,3), multidrug resistance-associated protein 2 (MRP2) and MRP3, has been elucidated in the literature. Furthermore, GA uptake can be estimated on either static images or on dynamic imaging, for example, the hepatic extraction fraction (HEF) and liver perfusion. GA-enhanced MRI has achieved an important role in evaluating morphology and function in chronic liver diseases (CLD), allowing to distinguish between the two subgroups of nonalcoholic fatty liver diseases (NAFLD), simple steatosis and nonalcoholic steatohepatitis (NASH), and help to stage fibrosis and cirrhosis, predict liver transplant graft survival, and preoperatively evaluate the risk of liver failure if major resection is planned. Finally, because of its noninvasive nature, GA-enhanced MRI can be used for long-term follow-up and post-treatment monitoring. This review article aims to describe the current role of GA-enhanced MRI in quantifying liver function in a variety of hepatobiliary disorders.

Assessment of liver function in dogs using the 13C-galactose breath test

2010 ◽  
Vol 185 (2) ◽  
pp. 152-156 ◽  
Author(s):  
S. Silva ◽  
C.A. Wyse ◽  
M.R. Goodfellow ◽  
P.S. Yam ◽  
T. Preston ◽  
...  
Keyword(s):  
Liver Function ◽  
Breath Test
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