Blood urea nitrogen (BUN) independently predicts mortality in critically ill patients admitted to ICU: A multicenter study

2018 ◽  
Vol 69 (1-2) ◽  
pp. 123-131 ◽  
Author(s):  
Bernhard Wernly ◽  
Michael Lichtenauer ◽  
Namkje A.R. Vellinga ◽  
E. Christiaan Boerma ◽  
Can Ince ◽  
...  
Keyword(s):  
Critically Ill ◽  
Blood Urea Nitrogen ◽  
Multicenter Study ◽  
Critically Ill Patients ◽  
Urea Nitrogen

scholarly journals Blood Urea Nitrogen and In-Hospital Mortality in Critically Ill Patients with Cardiogenic Shock: Analysis of the MIMIC-III Database

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
En-qian Liu ◽  
Chun-lai Zeng
Keyword(s):  
Logistic Regression ◽  
Hospital Mortality ◽  
Cardiogenic Shock ◽  
Critically Ill ◽  
Blood Urea Nitrogen ◽  
Critically Ill Patients ◽  
Medical Information ◽  
Multivariate Logistic Regression Model ◽  
Standard Deviation Increase ◽  
Urea Nitrogen

The association between blood urea nitrogen (BUN) and prognosis has been the focus of recent research. Therefore, the objective of this study was to investigate the association between BUN and hospital mortality in critically ill patients with cardiogenic shock (CS). This was a retrospective cohort study, in which data were obtained from the Medical Information Mart for Intensive Care III V1.4 database. Data from 697 patients with CS were analyzed. Logistic regression and subgroup analyses were used to assess the association between BUN and hospital mortality in patients with CS. The average age of the 697 participants was 71.14 years, and approximately 42.18% were men. In the multivariate logistic regression model, after adjusting for age, sex, diabetes, cardiac arrhythmias, urine output, simplified acute physiology score II, sequential organ failure assessment, creatinine, anion gap, and heart rate, high BUN demonstrated strong associations with increased in-hospital mortality (per standard deviation increase: odds ratio [OR] 1.47, 95% confidence interval [CI] 1.13–1.92). A similar result was observed in BUN tertile groups (BUN 23–37 mg/dL versus 6–22 mg/dL: OR [95% CI], 1.42 [0.86–2.34]; BUN 38–165 mg/dL versus 6–22 mg/dL: OR [95% CI], 1.99 [1.10–3.62]; P trend 0.0272). Subgroup analysis did not reveal any significant interactions among various subgroups, and higher BUN was associated with adverse clinical outcomes in patients with CS.

scholarly journals Elevation of blood urea nitrogen is predictive of long-term mortality in critically ill patients independent of “normal” creatinine*

2011 ◽  
Vol 39 (2) ◽  
pp. 305-313 ◽  
Author(s):  
Kevin Beier ◽  
Sabitha Eppanapally ◽  
Heidi S. Bazick ◽  
Domingo Chang ◽  
Karthik Mahadevappa ◽  
...  
Keyword(s):  
Critically Ill ◽  
Blood Urea Nitrogen ◽  
Critically Ill Patients ◽  
Urea Nitrogen ◽  
Long Term Mortality

scholarly journals Blood Urea Nitrogen to Serum Albumin Ratio Independently Predicts Mortality in Critically Ill Patients With Acute Pulmonary Embolism

2021 ◽  
Vol 27 ◽  
pp. 107602962110102
Author(s):  
Jihong Fang ◽  
Bin Xu
Keyword(s):  
Pulmonary Embolism ◽  
Serum Albumin ◽  
Critically Ill ◽  
Blood Urea Nitrogen ◽  
Critically Ill Patients ◽  
Acute Pulmonary Embolism ◽  
Acute Physiology Score ◽  
Icu Mortality ◽  
Urea Nitrogen ◽  
Icu Admission

Acute pulmonary embolism (APE) is one of the prominent causes of death in patients with cardiovascular disease. Currently, reliable biomarkers to predict the prognosis of patients with APE are limited. The present study aimed to investigate the association of blood urea nitrogen to serum albumin (B/A) ratio and intensive care unit (ICU) mortality in critically ill patients with APE. A retrospective cohort study was performed using data extracted from a freely accessible critical care database (MIMIC-III). Adult (≥18 years) patients of first ICU admission with a primary diagnosis of APE in the database were enrolled in the study. The primary endpoint was the ICU mortality rate while the 28-day mortality after ICU admission was the secondary endpoint. The data of survivors and non-survivors were compared. A total of 1048 patients with APE were enrolled in this study, of which 131 patients died in ICU and 169 patients died within 28 days after ICU admission. The B/A ratio in the non-survivors group was significantly higher compared to the survivors group ( P < 0.001). The multivariate analysis revealed that the B/A ratio was an independent predictor of ICU mortality (odds ratio [OR] 1.10, 95% CI 1.07-1.14, P < 0.001) and all-cause mortality within 28 days after ICU admission (hazard ratio [HR] 1.07, 95% CI 1.05-1.09, P < 0.001) in APE patients. The B/A ratio showed a greater area under the curve (AUC) of ICU mortality prediction (0.80; P < 0.001) than simplified acute physiology score II (SAPSII) (0.79), systemic inflammatory response syndrome score (SIRS) (0.62), acute physiology score III (APSIII) (0.76) and sequential organ failure assessment (SOFA) score (0.71). The B/A ratio could be a simple and useful prognostic tool to predict mortality in critically ill patients with APE.

scholarly journals Blood Urea Nitrogen (BUN) is independently associated with mortality in critically ill patients admitted to ICU

PLoS ONE ◽  
2018 ◽  
Vol 13 (1) ◽  
pp. e0191697 ◽  
Author(s):  
Okan Arihan ◽  
Bernhard Wernly ◽  
Michael Lichtenauer ◽  
Marcus Franz ◽  
Bjoern Kabisch ◽  
...  
Keyword(s):  
Critically Ill ◽  
Blood Urea Nitrogen ◽  
Critically Ill Patients ◽  
Urea Nitrogen

Multicenter study of ceftolozane/tazobactam for treatment of Pseudomonas aeruginosa infections in critically ill patients

2021 ◽  
pp. 106270
Author(s):  
Bárbara Balandin ◽  
Daniel Ballesteros ◽  
Rafael Ruiz de Luna ◽  
Loreto López-Vergara ◽  
Vicente Pintado ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Critically Ill ◽  
Multicenter Study ◽  
Critically Ill Patients

Increased Mortality Associated With Moderate Hyperbilirubinemia in Critically Ill Patients: Results From a Large Multicenter Study

CHEST Journal ◽  
2013 ◽  
Vol 144 (4) ◽  
pp. 363A
Author(s):  
Charalampos Pierrakos ◽  
Dimitris Velissaris ◽  
Thierry Gustot ◽  
Daniel Kett ◽  
Philippe Vanhems ◽  
...  
Keyword(s):  
Critically Ill ◽  
Multicenter Study ◽  
Critically Ill Patients ◽  
Large Multicenter Study
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