Beneficial effects of remote organ ischemic preconditioning on micro-rheological parameters during liver ischemia-reperfusion in the rat

2018 ◽  
Vol 70 (2) ◽  
pp. 181-190 ◽  
Author(s):  
Zsuzsanna Magyar ◽  
Anita Mester ◽  
Gabor Nadubinszky ◽  
Gabor Varga ◽  
Souleiman Ghanem ◽  
...  
2021 ◽  
Author(s):  
Camila Dossi ◽  
Romina Vargas ◽  
Rodrigo Valenzuela ◽  
Luis Videla

Liver ischemia-reperfusion injury (IRI) is a phenomenon inherent to hepatic surgery that severely compromises the organ functionality, whose underlying mechanisms involve cellular and molecular interrelated processes leading to the development...


2016 ◽  
Vol 13 (3) ◽  
pp. 2511-2517 ◽  
Author(s):  
TONG-MIN XUE ◽  
LI-DE TAO ◽  
JIE ZHANG ◽  
PEI-JIAN ZHANG ◽  
XIA LIU ◽  
...  

2015 ◽  
Vol 35 (6) ◽  
pp. 1625-1632 ◽  
Author(s):  
YICHAO YAN ◽  
GUANGYING LI ◽  
XIAOFENG TIAN ◽  
YINGJIANG YE ◽  
ZHIDONG GAO ◽  
...  

2011 ◽  
Vol 26 (3) ◽  
pp. 194-201 ◽  
Author(s):  
Tomaz de Jesus Maria Grezzana Filho ◽  
Tais Burmann de Mendonça ◽  
Gémerson Gabiatti ◽  
Graziella Rodrigues ◽  
Norma Anair Possa Marroni ◽  
...  

PURPOSE: To evaluate the effects of the topical liver hypothermia and IPC combination against I/R injury after initial reperfusion. METHODS: In 32 Wistar rats, partial liver ischemia was induced for 90 minutes in normothermia (IN), ischemic preconditioning (IPC), 26ºC topical hypothermia (H) and 26ºC topical hypothermia plus IPC (H+IPC). MAP, body temperature and bile flow were recorded each 15 minutes. Plasmatic injury markers and tissue antioxidant defenses were assessed after 120 minutes of reperfusion. RESULTS: MAP and body temperature remained constant during all experiment. Bile flow returned to levels similar to controls after 45 minutes of reperfusion in the H and H+IPC groups and increased significantly in comparison to the NI and IPC groups after 105 and 120 minutes. AST and ALT increased significantly in the normothermic groups in comparison to controls. TBARS levels decreased significantly in the H+IPC group in comparison to the other groups whereas Catalase levels increased significantly in the IPC group. SOD levels were significantly higher in the H group in comparison to all groups. CONCLUSION: The induction of 26ºC topical hypothermia associated or not to IPC protected the ischemic liver against ischemia/reperfusion injuries and allowed an early recovery of the hepatic function.


2014 ◽  
Vol 20 (28) ◽  
pp. 9506-9512 ◽  
Author(s):  
Bergthor Björnsson ◽  
Anders Winbladh ◽  
Linda Bojmar ◽  
Tommy Sundqvist ◽  
Per Gullstrand ◽  
...  

2014 ◽  
Vol 13 (1) ◽  
pp. 40-47 ◽  
Author(s):  
Estela RR Figueira ◽  
Joel A Rocha-Filho ◽  
Mauro Nakatani ◽  
Marcelo FS Buto ◽  
Eduardo R Tatebe ◽  
...  

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