Comparison of the simple red blood cell adhesiveness/aggregation test with the laser-assisted optical rotational cell analyzer: Red blood cell aggregation in patients with coronary artery disease and a healthy control group

2017 ◽  
Vol 65 (4) ◽  
pp. 363-371 ◽  
Author(s):  
Heike Preibsch ◽  
Stefanie Keymel ◽  
Malte Kelm ◽  
Theodor Baars ◽  
Petra Kleinbongard
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Cell Aggregation ◽  
Control Group ◽  
Red Blood Cell Aggregation ◽  
Healthy Control ◽  
Artery Disease ◽  
Cell Analyzer

Factors Increasing red Blood Cell Aggregation in Men with Coronary Artery Disease

1979 ◽  
Author(s):  
N. Boss ◽  
W. Bruder ◽  
M. Bierner ◽  
S. Koenig - Erich ◽  
E. Fleck ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Immune Complexes ◽  
Cell Aggregation ◽  
Coagulation System ◽  
Red Blood Cell Aggregation ◽  
Artery Disease ◽  
Blood Cell Aggregation

Red blood cell aggregation value (AW) was found to be of good diagnostic value ror coronary artery disease. Causes of increased aggregation value were investigated by means of protein analytical methods and standard laboratory techniques in 41 men with angiographically documented coronary artery disease. Best correlation coefficients were found between the red blood cell aggregation value and IgG, precipitable by 25g/1 polyethyleneglycol 6000 (r = 0.536; 2P ≤ 0.001). In coronary artery disease patients with no previous myocardial infarction (N=15) polyethyleneglycol precipitable IgM was found to correlate best with red blood cell aggregation (r = 0.707; 2P ≤ ! 0.01 ). In contrast to these results, patients without coronary stenosis demonstrated no significant correlation between the red blood cell aggregation value and the latter factorsThese results indicate a possible link between coronary artery disease, immune complexes and red blood cell aggregation. Platelet aggregation, as well as the coagulation system may also be influenced by these possibly specific immune complexes.

scholarly journals Сосудистая проницаемость и микрогемореология при системной склеродермии: возможности метода конъюнктивальной микроскопии

2020 ◽  
pp. 23-28
Keyword(s):  
Systemic Sclerosis ◽  
Blood Cell ◽  
Key Words ◽  
Vascular Permeability ◽  
Red Blood Cell ◽  
Cell Aggregation ◽  
Control Group ◽  
Age Group ◽  
Red Blood Cell Aggregation ◽  
Blood Cell Aggregation

In this article, the authors draw attention of readers to the capabilities of the conjunctival microscopy (CM) the method for studying the processes of vascular permeability and microhemorheology in patients with systemic sclerosis (SS). An original simultaneous examination of 48 patients with SS (mean age 51±1,7 years) and a comparable age group (4,74±2,3 years) of the control group of people without any diseases that might affect microcirculation (MC) by the CM-method was performed. The results demonstrated high informativeness of the CM-method in the diagnostics and assessment of vascular permeability and intravascular red blood cell aggregation (RBCA) in SS. The main changes in MC during SS revealed by the CM-method are the increase in vascular permeability and enhancement of RBCA in all types of microvessels. Key words: vascular permeability, intravascular red blood cell aggregation, conjunctival microscopy, systemic sclerosis.

Red blood cell distribution width and myocardial scar burden in coronary artery disease

2017 ◽  
Vol 93 (1104) ◽  
pp. 607-612 ◽  
Author(s):  
Caroline Jane Magri ◽  
Tan Xiao Tian ◽  
Liberato Camilleri ◽  
Robert Xuereb ◽  
Joseph Galea ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Myocardial Scar ◽  
Cell Distribution ◽  
Distribution Width ◽  
Scar Burden ◽  
Artery Disease ◽  
Red Blood Cell Distribution

scholarly journals Minimally invasive extracorporeal circulation in end-stage coronary artery disease patients undergoing myocardial revascularization

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Ignazio Condello ◽  
Giuseppe Santarpino ◽  
Francesco Bartolomucci ◽  
Giovanni Valenti ◽  
Nicola Di Bari ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Minimally Invasive ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Extracorporeal Circulation ◽  
Myocardial Revascularization ◽  
Artery Disease ◽  
Lactate Levels ◽  
End Stage

Abstract Background Patients with coronary artery disease and concomitant heart failure (left ventricular ejection fraction < 35%) requiring myocardial revascularization are at risk of poor long-term prognosis and higher mortality. The benefits of minimally invasive extracorporeal circulation (MiECC), particularly in end-stage coronary artery disease patients undergoing myocardial revascularization, have not been completely described. Materials and methods In this single-centre control study, 60 end-stage coronary artery disease patients undergoing isolated coronary artery bypass grafting (CABG) were included. Patients were divided into two groups of 30 patients each undergoing CABG using MiECC or conventional extracorporeal circulation (cECC). Results In the MiECC group, oxygen delivery index (DO2i) was 305 mL/min/m2 in relation to indexed oxygen extraction ratio (O2ERi) 21.5%, whereas in the cECC group DO2i was 288 mL/min/m2 in relation to O2ERi 25.6% (p = 0.037). Lactate levels > 3 mmol/L were reported in 7 MiECC patients vs 20 cECC patients (p = 0.038), with blood glucose peak. Mean nadir hemoglobin values during cardiopulmonary bypass (CPB) were 9.7 g/dL in the MiECC group vs 7.8 g/dL in the cECC group (p = 0.044). Cardiac index during CPB was 2.4 L/min/m2 in both groups. Red blood cell units administered were 8 vs 21 units in the MiECC vs cECC group (p = 0.022). A glycemic peak was recorded in 7 patients of the MiECC group and in 20 patients of the cECC group (p = 0.037). Conclusion In end-stage coronary artery disease, the MiECC technique was associated with a higher DO2i compared to cECC. MiECC patients showed a significant reduction in red blood cell unit administration and peak intraoperative lactate levels, which correlated with better postoperative outcome.

Is red blood cell glutathione a better marker for coronary artery disease than plasma glutathione?

2016 ◽  
Vol 252 ◽  
pp. e70
Author(s):  
A. Lima ◽  
R. Ferin ◽  
E. Santos ◽  
A. Fontes ◽  
S. Ferreira ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Plasma Glutathione ◽  
Artery Disease

scholarly journals Structural features of the lipid bilayer of the red blood cell membrane in people with isolated hypercholesterolemia without coronary artery disease and in patients with coronary artery disease

2017 ◽  
Vol 89 (4) ◽  
pp. 39-44
Author(s):  
A P Vasilev ◽  
N N Streltsova ◽  
N L Lystsova
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Angina Pectoris ◽  
Cell Membrane ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Free Cholesterol ◽  
Red Blood Cell Membrane ◽  
Cholesterol Levels ◽  
Artery Disease

Aim. To identify the specific features of modifying the lipid composition of the red blood cell membrane in people with isolated hypercholesterolemia without coronary heart disease (CHD) and in CHD patients with different functional classes of angina pectoris. Subjects and methods. 92 men with Functional Class II—IV stable angina, 22 men with isolated hypercholesterolemia (HC) without CHD, and 18 healthy men with normal cholesterol levels were examined. Blood plasma cholesterol levels were determined in all the examinees. The erythrocyte membrane was examined for the levels of lipid peroxidation (LPO) products, free cholesterol, calcium, and phospholipid fractions and for the activity of Na+/K+-, Mg2+- and Ca2+-ATPases; a bicycle exercise test was carried out. Results. As compared with persons with normal blood cholesterol levels, the examinees with HC without CHD were found to have higher levels of LPO products, lower levels of readily oxidizable phospholipid fractions, decreased activity of membrane-bound Na+/K+-, Mg2+-, and Ca2+-ATPases, and elevated concentrations of free cholesterol and calcium in the red blood cell membrane. Having the pronounced activity of free radical oxidation, the patients with CHD were detected to have deeper similar structural changes in the cell membrane, which became more severe with a larger number of affected coronary arteries. Conclusion. The findings suggest that the lipid structure of the cell membrane undergoes changes associated with its functional depression just at the preclinical stage of atherogenesis. Biomembrane structural modification in patients with angina pectoris progresses in proportion to the number of affected coronary arteries, by limiting the functional reserve of the cell and whole body.

scholarly journals Red blood cell MUFAs and risk of coronary artery disease in the Physicians’ Health Study

2013 ◽  
Vol 98 (3) ◽  
pp. 749-754 ◽  
Author(s):  
Chisa Matsumoto ◽  
Nirupa R Matthan ◽  
Alice H Lichtenstein ◽  
J Michael Gaziano ◽  
Luc Djoussé
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Health Study ◽  
Artery Disease
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