Influence of iodine-containing radiographic contrast media on the phenotype of erythrocytes from different laboratory animal species

2013 ◽  
Vol 55 (4) ◽  
pp. 473-479 ◽  
Author(s):  
B. Hiebl ◽  
C. Hopperdietzel ◽  
H. Hünigen ◽  
K. Dietze ◽  
S. Klein ◽  
...  
Keyword(s):  
Contrast Media ◽  
Laboratory Animal ◽  
Animal Species ◽  
Radiographic Contrast ◽  
Radiographic Contrast Media

Adverse Drug Reactions to Radiographic Contrast Media in a Teaching Hospital in North India: An Observational Study

2019 ◽  
Vol 14 (2) ◽  
pp. 122-126
Author(s):  
Deepti Chopra ◽  
Abhinav Jain ◽  
Richa Garg ◽  
Shreya Dhingra
Keyword(s):  
Observational Study ◽  
Contrast Media ◽  
Adverse Drug Reactions ◽  
Teaching Hospital ◽  
Adverse Reactions ◽  
North India ◽  
Drug Reactions ◽  
Iodinated Contrast ◽  
Radiographic Contrast ◽  
Radiographic Contrast Media

Background: Radiocontrast media are used extensively nowadays to visualize internal organs. Currently, non-ionic iodinated contrast media are used which are generally considered to be safe but some adverse reactions have been reported. Thus, the present study was carried out to analyze the nature and incidence of adverse drug reactions (ADRs) to radiographic contrast media in a teaching hospital. Methods:An observational study carried out for a period of six months in a teaching hospital. Contrast media induced adverse reactions were analyzed in terms of affected organs, rate, causality assessment, severity and preventability. The treatment and outcomes of adverse events were also recorded. Naranjo Probability Scale was used to evaluate the relationship between the contrast agent used and the suspected ADR. The severity of the suspected ADRs was determined using Hartwig Scale and preventability was assessed using modified Schumock and Thornton criterion. Results:A total of 15 suspected ADRs occurred in 11 patients with an incidence of 1.4%. It included 5 (45.4%) males and 6 (54.5%) females (p < 05). The highest percentage (72.7 %) of ADRs was seen in adult patients, the mean age being 40.8 years. Vomiting (33.3%) was the most common ADR noted followed by severe nausea and rashes. 64.7 % of ADRs were categorized as probable and 35.3 % were possible. Adverse reactions required treatment in 46.6% patients. There was no fatality reported. Conclusion:The reactions observed were mild to moderate in severity and occurred within 30 minutes of the administration of the contrast.

Influence of various radiographic contrast media on the buckling of endothelial cells

2008 ◽  
Vol 76 (2) ◽  
pp. 110-113 ◽  
Author(s):  
Ralf-Peter Franke ◽  
Rosemarie Fuhrmann ◽  
Bernhard Hiebl ◽  
Friedrich Jung
Keyword(s):  
Endothelial Cells ◽  
Contrast Media ◽  
Radiographic Contrast ◽  
Radiographic Contrast Media

Acute Renal Failure Caused by Low-Osmolar Radiographic Contrast Media in Patients with Diabetic Nephropathy

1989 ◽  
Vol 23 (4) ◽  
pp. 315-317 ◽  
Author(s):  
Barbro Spångberg-Viklund ◽  
Tomas Nikonoff ◽  
Marc Lundberg ◽  
Rutger Larsson ◽  
Tommy Skau ◽  
...  
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Diabetic Nephropathy ◽  
Contrast Media ◽  
Radiographic Contrast ◽  
Radiographic Contrast Media

The Newer Radiographic Contrast Media

1992 ◽  
Vol 31 (9) ◽  
pp. 554-558 ◽  
Author(s):  
Kathleen Dunne Eggli
Keyword(s):  
Contrast Media ◽  
Radiographic Contrast ◽  
Radiographic Contrast Media

The Effect of Radiographic Contrast Media on the Chemotaxis of Granulocytes

1988 ◽  
Vol 23 (8) ◽  
pp. 621-626 ◽  
Author(s):  
J??RGEN GEORGSEN ◽  
FINN RASMUSSEN ◽  
JENS O. PEDERSEN
Keyword(s):  
Contrast Media ◽  
Radiographic Contrast ◽  
Radiographic Contrast Media

scholarly journals Influence of ionic and non-ionic radiographic contrast media on leukocyte adhesion molecules

2003 ◽  
Vol 12 (5) ◽  
pp. 269-275 ◽  
Author(s):  
Guy L. J. Vermeiren ◽  
Roel Willems ◽  
Marc J. Claeys ◽  
Chris Vrints ◽  
Herman Slegers ◽  
...  
Keyword(s):  
Coronary Angiography ◽  
Contrast Media ◽  
Adhesion Molecules ◽  
Leukocyte Adhesion ◽  
Serum Samples ◽  
Cd11b Expression ◽  
Radiographic Contrast ◽  
Radiographic Contrast Media

Background:Many papers have focused on the importance of granulocytes in the process of reperfusion and ischemia. Most of the clinical studies measured several parameters of this process during and after coronary angiography, without taking into account the effect of the radiographic contrast media (RCM) used during this procedure.Materials and methods:We performed a randomized patient study(n=37)to evaluate the effect of ionic and non-ionic RCM on granulocyte adhesion during coronary angiography. We also evaluated the influence of the ionicity and osmolarity of the different substances on granulocyte adhesion molecules inin vitroexperiments.Results:The osmolarity of patient serum samples increased from 302±1 to 309±1 mOsm/kg(P<0.05)after infusion of RCM. The CD11b expression in the samples of the non-ionic RCM treated group increased from 221±21 MFI to 377±30 MFI(P<0.05)measured as the absolute mean fluorescence intensity (MFI), yet did not alter significantly in the ionic RCM group. In contrast, thein vitroexperiments showed a reduction of the CD11b expression from 360±70 MFI to 149±30 MFI(P<0.05)in the ionic RCM group.Conclusions:The upregulation of adhesion molecules was significantly reducedin vivowith ionic RCM, while ionic substances caused opposite effectsin vitro. This effect should be taken into account when performing leukocyte functional analysis of samples taken during angiography.

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