LCP1 is a prognostic biomarker correlated with immune infiltrates in gastric cancer

2020 ◽  
pp. 1-21
Author(s):  
Qingwen Zeng ◽  
Leyan Li ◽  
Zongfeng Feng ◽  
Lianghua Luo ◽  
Jianbo Xiong ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Immune Reaction ◽  
Prognostic Biomarker ◽  
Tumor Infiltrating Lymphocytes ◽  
Strongly Correlated ◽  
Tumor Aggressiveness ◽  
R Software ◽  
Immune Infiltration ◽  
Infiltrating Lymphocytes

BACKGROUND: Previous studies have identified LCP1 as a diagnostic and prognostic marker in several cancers. However, the role of LCP1 in gastric cancer (GC) and its effect on tumor immune infiltration remain unclear. OBJECTIVE: The aim was to explore the role of LCP1 in GC and its effect on tumor immune infiltration. METHODS: We explored the expression of LCP1 relative to clinicopathology in GC patients by bioinformatics analysis and immunohistochemistry. Using cBioportal database, we analyzed the characteristic genetic variations of LCP1 in GC. In addition, we evaluated the correlation between LCP1 expression and tumor-infiltrating lymphocytes (TILs) using R software, TIMER and TISIDB databases. Finally, we analyzed the biological functions in which LCP1 may participate and the signaling pathways it may regulate. RESULTS: Here, we showed that LCP1 expression is significantly correlated with tumor aggressiveness and poor prognosis in GC patients. Additionally, the results indicated that LCP1 was associated with TILs, including both immunosuppressive and immunosupportive cells, and was strongly correlated with various immune marker sets in GC. GSEA analysis demonstrated that LCP1 expression played an important role in lymphocyte formation and immune reaction. CONCLUSIONS: LCP1 may be a potential prognostic biomarker for GC patients and a marker for tumor immunotherapy.

scholarly journals Prognostic role of tumor-infiltrating lymphocytes in gastric cancer

Medicine ◽  
2018 ◽  
Vol 97 (32) ◽  
pp. e11769 ◽  
Author(s):  
Jung Soo Lee ◽  
Hye Sung Won ◽  
Der Sheng Sun ◽  
Ji Hyung Hong ◽  
Yoon Ho Ko
Keyword(s):  
Gastric Cancer ◽  
Tumor Infiltrating Lymphocytes ◽  
Prognostic Role ◽  
Infiltrating Lymphocytes

An integrative pan-cancer analysis of COPB1 based on data mining

2020 ◽  
pp. 1-15
Author(s):  
Heyan Chen ◽  
Kunlong Li ◽  
Yijun Li ◽  
Peilin Xie ◽  
Jianjun He ◽  
...  
Keyword(s):  
Prognostic Biomarker ◽  
Tumor Infiltrating Lymphocytes ◽  
Normal Tissues ◽  
Kaplan Meier ◽  
Online Databases ◽  
Infiltrating Lymphocytes ◽  
The Relationship ◽  
Kaplan Meier Plotter ◽  
Pan Cancer

BACKGROUND: Cancer will become the leading cause of death worldwide in the 21st century, meanwhile, immunotherapy is the most popular cancer treatment methods in recent years. COPI Coat Complex Subunit Beta 1 (COPB1) relates to human innate immunity. However, the role of COPB1 in pan-cancer remains unclear. OBJECTIVE: The purpose of this study was to explore the relationship between COPB1 mRNA expression and tumor infiltrating lymphocytes and immune examination sites in pan-cancer. METHODS: Data from multiple online databases were collected. The BioGPS, UALCAN Database, COSMIC, cBioPortal, Cancer Regulome tools, Kaplan-Meier Plotter and TIMER website were utilized to perform the analysis. RESULTS: Upregulation of COPB1 has been widely observed in tumors tissues compared with normal tissues. Although COPB1 has poor prognosis in pan-cancer, COPB1 high expression was beneficial to the survival of ESCA patients. Unlike ESCA, COPB1 expression in STAD was positively correlated with tumor infiltrating lymphocytes, including B cells, CD8+ T cells, neutrophils, macrophages, and dendritic cells. Finally, we also found that the expression of COPB1 in STAD was positively correlated with PD-L1 and CTLA4. CONCLUSIONS: COPB1 may be a prognostic biomarker for pan-carcinoma, and also provide an immune anti-tumor strategy for STAD based on the expression of COPB1.

scholarly journals Prognostic role of tumor-infiltrating lymphocytes in gastric cancer: a meta-analysis

Oncotarget ◽  
2017 ◽  
Vol 8 (34) ◽  
pp. 57386-57398 ◽  
Author(s):  
Xiao Zheng ◽  
Xing Song ◽  
Yingjie Shao ◽  
Bin Xu ◽  
Lujun Chen ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Meta Analysis ◽  
Tumor Infiltrating Lymphocytes ◽  
Prognostic Role ◽  
Infiltrating Lymphocytes

scholarly journals An Immunosuppressive Status Classifier to Predict Recurrence and Assist in Decision Regarding Postoperative Adjuvant Treatment in Gastric Cancer

2021 ◽  
Author(s):  
Jia-Bin Wang ◽  
Qing-Zhu Qiu ◽  
Ning-Zi Lian ◽  
Hua-Gen Wang ◽  
Qiao-Ling Zheng ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Adjuvant Treatment ◽  
Cox Regression ◽  
Treatment Options ◽  
Recurrence Score ◽  
Tumor Infiltrating Lymphocytes ◽  
Immunohistochemical Analysis ◽  
Postoperative Treatment ◽  
Immune Infiltration ◽  
Infiltrating Lymphocytes

Abstract Background: Suppression of the immune microenvironment is a crucial cause of postoperative tumor recurrence. We constructed an immune infiltration classifier based on immunosuppressive indicators to predict recurrence and guide postoperative treatment for gastric cancer (GC).Methods: Immunohistochemical analysis was performed for 825 GC tissues to evaluate immunosuppressive indicators. An immunosuppressive recurrence score (IRS) based on six immunosuppressive indicators was determined using the Lasso Cox method to predict recurrence outcomes. The association between immune infiltration and IRS was assessed using immunohistochemistry and multiplexed immunofluorescence staining. A nomogram predicting recurrence-free survival (RFS) was constructed by integrating IRS and significant clinicopathological features using the Cox regression model.Results: The IRS and IRS-based nomogram showed remarkable accuracy and reliability for predicting the recurrence outcome. Moreover, elevated IRS was associated with locoregional recurrence and failure of postoperative adjuvant chemotherapy. We also identified that the increased IRS indicated the inhibition of anti-tumor effect of CD8+ tumor-infiltrating lymphocytes (TILs) in the invasive margin (IM).Conclusion: IRS can predict the recurrence outcome of GC patients by comprehensively distinguishing the immune infiltration status, which assists in the selection of different adjuvant treatment options

scholarly journals Prognostic Role of Tumor‐Infiltrating Lymphocytes and Tumor Budding in Early Oral Tongue Carcinoma

2021 ◽  
Author(s):  
Yukiko Hori ◽  
Akira Kubota ◽  
Tomoyuki Yokose ◽  
Madoka Furukawa ◽  
Takeshi Matsushita ◽  
...  
Keyword(s):  
Tumor Infiltrating Lymphocytes ◽  
Tumor Budding ◽  
Tongue Carcinoma ◽  
Oral Tongue ◽  
Prognostic Role ◽  
Infiltrating Lymphocytes
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