Tumor marker index based on preoperative SCC and CYFRA 21-1 is a significant prognostic factor for patients with resectable esophageal squamous cell carcinoma

2019 ◽  
Vol 25 (3) ◽  
pp. 243-250
Author(s):  
Yufeng Qiao ◽  
Chuangui Chen ◽  
Jie Yue ◽  
Zhentao Yu
Keyword(s):  
Squamous Cell Carcinoma ◽  
Prognostic Factor ◽  
Esophageal Squamous Cell Carcinoma ◽  
Tumor Marker ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Significant Prognostic Factor ◽  
Marker Index ◽  
Resectable Esophageal

α-catenin is a significant prognostic factor than E-cadherin in esophageal squamous cell carcinoma

2007 ◽  
Vol 95 (2) ◽  
pp. 148-155 ◽  
Author(s):  
Tetsuro Setoyama ◽  
Shoji Natsugoe ◽  
Hiroshi Okumura ◽  
Masataka Matsumoto ◽  
Yasuto Uchikado ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Prognostic Factor ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Significant Prognostic Factor ◽  
E Cadherin

scholarly journals Serum Clusterin as a Tumor Marker and Prognostic Factor for Patients with Esophageal Cancer

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Wei Guo ◽  
Xiao Ma ◽  
Christine Xue ◽  
Jianfeng Luo ◽  
Xiaoli Zhu ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Prognostic Factor ◽  
Esophageal Squamous Cell Carcinoma ◽  
Tumor Marker ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Univariate Analysis ◽  
Rank Test ◽  
Healthy Controls ◽  
The Mean

Background. Recent studies have revealed that clusterin is implicated in many physiological and pathological processes, including tumorigenesis. However, the relationship between serum clusterin expression and esophageal squamous cell carcinoma (ESCC) is unclear.Methods. The serum clusterin concentrations of 87 ESCC patients and 136 healthy individuals were examined. An independent-samples Mann-WhitneyUtest was used to compare serum clusterin concentrations of ESCC patients to those of healthy controls. Univariate analysis was conducted using the log-rank test and multivariate analyses were performed using the Cox proportional hazards model.Results. In healthy controls, the mean clusterin concentration was288.8±75.1 μg/mL, while in the ESCC patients, the mean clusterin concentration was higher at412.3±159.4 μg/mL (P<0.0001). The 1-, 2-, and 4-year survival rates for the 87 ESCC patients were 89.70%, 80.00%, and 54.50%. Serum clusterin had an optimal diagnostic cut-off point (serum clusterin concentration = 335.5 μg/mL) for esophageal squamous cell carcinoma with sensitivity of 71.26% and specificity of 77.94%. And higher serum clusterin concentration (>500 μg/mL) indicated better prognosis (P=0.030).Conclusions. Clusterin may play a key role during tumorigenesis and tumor progression of ESCC and it could be applied in clinical work as a tumor marker and prognostic factor.

Progress of Chemoradiotherapy for Resectable Esophageal Squamous Cell Carcinoma

2012 ◽  
Vol 63 (2) ◽  
pp. 195-195
Author(s):  
K. Minashi ◽  
T. Yano ◽  
T. Kojima ◽  
M. Onozawa ◽  
K. Nihei ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Resectable Esophageal

scholarly journals Mina53 as a Potential Prognostic Factor for Esophageal Squamous Cell Carcinoma

2004 ◽  
Vol 10 (21) ◽  
pp. 7347-7356 ◽  
Author(s):  
Makoto Tsuneoka ◽  
Hiromasa Fujita ◽  
Nobuyuki Arima ◽  
Kwesi Teye ◽  
Torahiko Okamura ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Prognostic Factor ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Potential Prognostic Factor

scholarly journals The preoperative HALP score (hemoglobin, albumin, lymphocyte and platelet) is a useful predictor in patients with resectable esophageal squamous cell carcinoma

2021 ◽  
Author(s):  
Ji-Feng Feng ◽  
Liang Wang ◽  
Xun Yang
Keyword(s):  
Squamous Cell Carcinoma ◽  
Prognostic Factor ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Roc Curve ◽  
Curative Resection ◽  
Cox Regression ◽  
Prognostic Score ◽  
Cancer Specific Survival

The hemoglobin, albumin, lymphocyte, and platelet (HALP) score has been confirmed as a prognostic factor in several types of cancers. The current study aimed to assess the prognostic value of preoperative HALP score, an inflammatory and nutritional based score, in predicting cancer-specific survival (CSS) in resectable patients undergoing curative resection for esophageal squamous cell carcinoma (ESCC). The clinical data of 355 consecutive patients with ESCC who underwent curative resection were retrospectively conducted and analyzed. The receiver operating characteristic (ROC) curve was used to determine the optimal cut-off value for preoperative HALP. The areas under the curve (AUC) for preoperative HALP and other variables were calculated and compared. Cox regression analyses and Kaplan-Meier methods were used to identify the factors associated with CSS. According to the ROC curve, the optimal cut-off value for preoperative HALP was 31.8. The 5-year CSS for preoperative HALP low (≤31.8) and high (>31.8) was 15.1% and 47.5%, respectively (p<0.001). Preoperative HALP had reliable abilities to predict CSS in resectable ESCC patients in any stage or gender, according to the subgroup analysis based on the patients' cancer stage and gender. Multivariate analyses confirmed that preoperative HALP was an independent prognostic score regarding CSS in patients with resectable ESCC (p<0.001). This study confirmed that the preoperative HALP score could be regarded as a potential independent prognostic factor for CSS in patients with resectable ESCC.

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