Increased expression of lncRNA SNHG12 predicts a poor prognosis of nasopharyngeal carcinoma and regulates cell proliferation and metastasis by modulating Notch signal pathway

2018 ◽  
Vol 23 (4) ◽  
pp. 603-613 ◽  
Author(s):  
Zhi-Biao Liu ◽  
Chen Tang ◽  
Xin Jin ◽  
Shou-Hou Liu ◽  
Wen Pi
Keyword(s):  
Cell Proliferation ◽  
Nasopharyngeal Carcinoma ◽  
Poor Prognosis ◽  
Signal Pathway ◽  
Notch Signal ◽  
Proliferation And Metastasis ◽  
Notch Signal Pathway ◽  
Cell Proliferation And Metastasis

microRNA-30e-5p Up-Regulation Subdues Osteosarcoma Cell Proliferation and Metastasis via Regulating Collagen Triple Helix Repeat Containing 1

2021 ◽  
Vol 11 (9) ◽  
pp. 1683-1690
Author(s):  
Yong Duan ◽  
Jin Hai Tan ◽  
Sheng Xiang Tao ◽  
SiYi Liu ◽  
Qian Jin Zheng
Keyword(s):  
Cell Proliferation ◽  
Distant Metastasis ◽  
Poor Prognosis ◽  
Triple Helix ◽  
Osteosarcoma Cell ◽  
Clinical Indicators ◽  
Qrt Pcr ◽  
Collagen Triple Helix ◽  
Proliferation And Metastasis ◽  
Cell Proliferation And Metastasis

The cancerous and matched para-carcinoma tissues were gained from total of 40 patients with OS, miR-30e-5p level was monitored through qRT-PCR, and the relevance between abnormal expressed miR-30e-5p and clinical indicators was uncovered. Simultaneously, miR-30e-5p expressive level in common-applied OS cells was detected by qRT-PCR. Additionally, miR-30e-5p suppression and overexpression models were constructed, and CCK-8 and transwell procedures were subsequently executed to analyze the influences of miR-30e-5p in OS cells. Further, relation between miR-30e-5p and CTHRC1 was forecased, meanwhile CTHRC1 function in miR-30e-5p-modulated OS cells was explored. Low expressed miR-30e-5p is linked to the distant metastasis and poor prognosis, which may restrain the malignant progression of OS by targeting CTHRC1.

scholarly journals PPAR-γ Ligand Inhibits Nasopharyngeal Carcinoma Cell Proliferation and Metastasis by Regulating E2F2

PPAR Research ◽  
2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Ping-Li Yang ◽  
Jia-Shun Wang ◽  
Xiao-Mei Cheng ◽  
Jing-Cai Chen ◽  
Hui Zhu ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Proliferation ◽  
Nasopharyngeal Carcinoma ◽  
Cell Lines ◽  
Cellular Proliferation ◽  
Nuclear Hormone Receptor ◽  
Advanced Tumor Stage ◽  
Study Results ◽  
Proliferation And Metastasis ◽  
Cell Proliferation And Metastasis

Purpose. Peroxisome proliferator-activated receptor-γ (PPAR-γ) is a nuclear hormone receptor with a key role in lipid metabolism. Previous studies have identified various roles of PPAR-γ in cell cycle progression, cellular proliferation, and tumor progression. However, no report has described a role for PPAR-γ in human nasopharyngeal carcinoma (NPC). Notably, some studies have reported a relationship between PPAR-γ and E2F transcription factor 2 (E2F2), which has been identified as a regulator of cell cycle, apoptosis, and the DNA damage response. Notably, E2F2 has also been reported to correlate with a poor prognosis in patients with various malignancies. Methods. We used immunohistochemical (IHC) and western blot methods to evaluate PPAR-γ and E2F2 expression and function in nonkeratinizing NPC and nasopharyngitis (NPG) tissue samples, as well as western blotting and CCK8 analyses in the NPC cell lines, CNE1 and CNE2. Results. We observed lower levels of PPAR-γ expression in nonkeratinizing NPC tissues compared with NPG tissues and determined an association between a low level of PPAR-γ expression with a more advanced tumor stage. Furthermore, strong E2F2 expression was detected in nonkeratinizing NPC tissues. We further demonstrated that rosiglitazone, a PPAR-γ agonist, reduced E2F2 expression and proliferation in NPC cell lines. Conclusions. Our study results revealed a novel role for the PPAR-γ–E2F2 pathway in controlling NPC cell proliferation and metastasis.

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