Phytochemical and anti-inflammatory activities of aqueous leaf extract of Indian borage (oregano) on rats induced with inflammation

2018 ◽  
Vol 22 (2) ◽  
pp. 257-265
Author(s):  
David Bolaji Akinbo ◽  
Augustine A. Onyeaghala ◽  
Jennifer Ochuko Emomidue ◽  
Stephanie Okhuriafe Ogbhemhe ◽  
Henry Chijindu Okpoli
Keyword(s):  
Leaf Extract ◽  
Aqueous Leaf Extract ◽  
Anti Inflammatory

Anti-inflammatory activity of aqueous leaf extract of Phyllanthus muellerianus (Kuntze) Exell. and its major constituent, geraniin

2016 ◽  
Vol 187 ◽  
pp. 17-27 ◽  
Author(s):  
Yaw Duah Boakye ◽  
Christian Agyare ◽  
Wonder Kofi Mensah Abotsi ◽  
Patrick George Ayande ◽  
Paul Poku Sampene Ossei
Keyword(s):  
Leaf Extract ◽  
Inflammatory Activity ◽  
Major Constituent ◽  
Aqueous Leaf Extract ◽  
Anti Inflammatory

scholarly journals Comparative Effect of Aspirin, Meloxicam and Terminalia catappa Leaf Extract on Serum Levels of Some Inflammatory Markers in Alloxan Induced Diabetic Rats

2019 ◽  
pp. 1-10
Author(s):  
Ezekiel E. Ben ◽  
Asuquo E. Asuquo ◽  
Daniel U. Owu
Keyword(s):  
Body Weight ◽  
Interleukin 6 ◽  
Leaf Extract ◽  
Serum Levels ◽  
Diabetic Rats ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Terminalia Catappa ◽  
Aqueous Leaf Extract ◽  
Anti Inflammatory

Background: The association between diabetes mellitus and inflammation is established but the use of non-steroidal anti-inflammatory drugs is not without some health risk. Aim: The study was aimed at comparing the levels of some inflammatory biomarkers in diabetic rats treated with aqueous leaf extract of Terminalia catappa, non steroidal anti-inflammatory drugs (NSAIDs) and exogenous insulin. Materials and Methods: Thirty six (36) Wistar rats were assigned to 6 groups of 6 animals each. Group 1 and 2 served as normal and diabetic controls and received orally 5ml/kg body weight of distilled water. Group 3 was diabetic treated orally with 130mg/kg body weight of aqueous leaf extract of Terminalia catappa.  And groups 4, 5 and 6 were administered orally with aspirin (30mg/kg), meloxicam (2mg/kg) and 0.75U/kg body weight of insulin subcutaneously. Diabetes was induced with intraperitoneal injection of 150mg/kg body weight of alloxan solution and diabetes confirmed after 72 hours with blood glucose levels ≥200mg/dl. The experiment lasted for 14 days and blood was collected by cardiac puncture for serum analysis of C-reactive protein, Interleukin-6 and Fibrinogen by ELISA method. Results: The results showed significant (P<0.05) increase in serum levels of C-reactive protein, Interleukin-6 and blood fibrinogen in diabetic group compared to control. These inflammatory biomarker were significantly (P<0.05) reduced by the extract, aspirin, meloxicam and insulin.  Conclusion: The reduced levels of C-reactive protein, Interleukin-6 and fibrinogen by aqueous leaf extract of Terminalia catappa was significant compared to aspirin and meloxicam. This may present the extract as a potent anti-inflammatory agent and could complement the function of insulin in diabetes treatment.

One-step biofabrication of copper nanoparticles from Aegle marmelos correa aqueous leaf extract and evaluation of its anti-inflammatory and mosquito larvicidal efficacy

RSC Advances ◽  
2014 ◽  
Vol 4 (93) ◽  
pp. 51459-51470 ◽  
Author(s):  
Gangadhara Angajala ◽  
Pasupala Pavan ◽  
R. Subashini
Keyword(s):  
Copper Nanoparticles ◽  
Leaf Extract ◽  
Aegle Marmelos ◽  
One Step ◽  
Aqueous Leaf Extract ◽  
Anti Inflammatory

Biofabrication of CuNps from AmC aqueous leaf extract of various sizes with good anti-inflammatory and mosquito larvicidal efficacy.

scholarly journals Suppression of inflammatory mediators by aqueous leaf extract of Crotalaria verrucosa: in vivo and in vitro analysis

2020 ◽  
Vol 9 (12) ◽  
pp. 1897
Author(s):  
Mohammad Mustakim Billah ◽  
Abir Huzaifa ◽  
M. Abdul Kader Khan ◽  
Nusrat Jahan Vabna ◽  
Kashfia Nawrin ◽  
...  
Keyword(s):  
Leaf Extract ◽  
Protein Denaturation ◽  
Inflammatory Activity ◽  
Medicinal Value ◽  
Aqueous Leaf Extract ◽  
Anti Inflammatory ◽  
Vitro Analysis ◽  
In Vitro Analysis

Background: Crotalaria verrucosa is a traditional plant frequently prescribed by the tribes for its medicinal value against inflammation. The present study was designed to investigate the scientific basis for medicinal value in inflammation by in vivo and in vitro analysis.Methods: Anti-inflammatory activity of the plant’s leaf was evaluated by two in vivo methods - carrageenan induced rat paw edema and xylene induced mice ear edema. Moreover, in vitro analysis was performed through heat induced hemolysis and heat induced protein denaturation methods.Results: The inflammation produced by carrageenan and xylene were effectively suppressed by the aqueous leaf extract of C. verrucosa (CVAQ) at 600 mg/kg body weight which was comparable to the standards. In heat induced hemolysis test the extract was able to inhibit the lysis up to 70% at 500 µg/ml whereas in heat induced protein denaturation test it reduces the percentage till 69% at the same concentration.Conclusions: The findings suggested that CVAQ possess moderate to high anti-inflammatory activity when applied in low to high concentrated doses. However, the study can only conclude from this basic evaluation that the extract needs to be further investigated for identifying the potential compound which contributed to such medicinal value of the plant.

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