Protein and DNA evidences of HCMV infection in primary breast cancer tissues and metastatic sentinel lymph nodes

2018 ◽  
Vol 21 (4) ◽  
pp. 769-780 ◽  
Author(s):  
Jian Cui ◽  
Qian Wang ◽  
Hai-Bo Wang ◽  
Bin Wang ◽  
Ling Li
Keyword(s):  
Breast Cancer ◽  
Lymph Nodes ◽  
Primary Breast Cancer ◽  
Hcmv Infection ◽  
Sentinel Lymph Nodes ◽  
Cancer Tissues

scholarly journals Prospective evaluation of the limitations of near-infrared imaging in detecting axillary sentinel lymph nodes in primary breast cancer

2018 ◽  
Vol 24 (6) ◽  
pp. 1006-1009 ◽  
Author(s):  
Chafika Mazouni ◽  
Meriem Koual ◽  
Frederic De Leeuw ◽  
Angelica Conversano ◽  
Nicolas Leymarie ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Nodes ◽  
Primary Breast Cancer ◽  
Near Infrared ◽  
Infrared Imaging ◽  
Sentinel Lymph Nodes ◽  
Prospective Evaluation ◽  
Near Infrared Imaging

scholarly journals High Prevalence of Human Cytomegalovirus Proteins and Nucleic Acids in Primary Breast Cancer and Metastatic Sentinel Lymph Nodes

PLoS ONE ◽  
2013 ◽  
Vol 8 (2) ◽  
pp. e56795 ◽  
Author(s):  
Chato Taher ◽  
Jana de Boniface ◽  
Abdul-Aleem Mohammad ◽  
Piotr Religa ◽  
Johan Hartman ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Nucleic Acids ◽  
Lymph Nodes ◽  
Human Cytomegalovirus ◽  
Primary Breast Cancer ◽  
Sentinel Lymph Nodes ◽  
High Prevalence

Reply to: Prospective evaluation of the limitations of near‐infrared imaging in detecting axillary sentinel lymph nodes in primary breast cancer

2019 ◽  
Vol 26 (2) ◽  
pp. 343-344
Author(s):  
Federico Cattin ◽  
Tommaso Fogacci ◽  
Gianluca Frisoni ◽  
Gloria Semprini ◽  
Luca Fabiocchi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Nodes ◽  
Primary Breast Cancer ◽  
Near Infrared ◽  
Infrared Imaging ◽  
Sentinel Lymph Nodes ◽  
Prospective Evaluation ◽  
Near Infrared Imaging

scholarly journals Metastatic status of sentinel lymph nodes in breast cancer determined with photoacoustic microscopy via dual-targeting nanoparticles

2020 ◽  
Vol 9 (1) ◽  
Author(s):  
Yanfeng Dai ◽  
Xiang Yu ◽  
Jianshuang Wei ◽  
Fanxin Zeng ◽  
Yiran Li ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Nodes ◽  
Scavenger Receptor ◽  
Intradermal Injection ◽  
Sentinel Lymph Nodes ◽  
Breast Cancer Surgery ◽  
Photoacoustic Microscopy ◽  
Dual Targeting ◽  
Scavenger Receptor Class ◽  
Distinct Distribution

Abstract Detection of sentinel lymph nodes (SLNs) is critical to guide the treatment of breast cancer. However, distinguishing metastatic SLNs from normal and inflamed lymph nodes (LNs) during surgical resection remains a challenge. Here, we report a CD44 and scavenger receptor class B1 dual-targeting hyaluronic acid nanoparticle (5K-HA-HPPS) loaded with the near-infra-red fluorescent dye DiR-BOA for SLN imaging in breast cancer. The small sized (~40 nm) self-assembled 5K-HA-HPPSs accumulated rapidly in the SLNs after intradermal injection. Compared with normal popliteal LNs (N-LN), there were ~3.2-fold and ~2.4-fold increases in fluorescence intensity in tumour metastatic SLNs (T-MLN) and inflamed LNs (Inf-LN), respectively, 6 h after nanoparticle inoculation. More importantly, photoacoustic microscopy (PAM) of 5K-HA-HPPS showed a significantly distinct distribution in T-MLN compared with N-LN and Inf-LN. Signals were mainly distributed at the centre of T-MLN but at the periphery of N-LN and Inf-LN. The ratio of PA intensity (R) at the centre of the LNs compared with that at the periphery was 5.93 ± 0.75 for T-MLNs of the 5K-HA-HPPS group, which was much higher than that for the Inf-LNs (R = 0.2 ± 0.07) and N-LNs (R = 0.45 ± 0.09). These results suggest that 5K-HA-HPPS injection combined with PAM provides a powerful tool for distinguishing metastatic SLNs from pLNs and inflamed LNs, thus guiding the removal of SLNs during breast cancer surgery.

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