PPARGC1A and ADIPOQ polymorphisms are associated with aggressive prostate cancer in Mexican-Mestizo men with overweight or obesity

2017 ◽  
Vol 19 (3) ◽  
pp. 297-303 ◽  
Author(s):  
Patricia Canto ◽  
Jesús Benítez Granados ◽  
Guillermo Feria-Bernal ◽  
Ramón Mauricio Coral-Vázquez ◽  
Eduardo García-García ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Aggressive Prostate Cancer ◽  
Mexican Mestizo ◽  
Overweight Or Obesity

Genetic variants in ATP6 and ND3 mitochondrial genes are not associated with aggressive prostate cancer in Mexican–Mestizo men with overweight or obesity

2016 ◽  
Vol 19 (3) ◽  
pp. 187-191 ◽  
Author(s):  
Patricia Canto ◽  
Jesús Benítez Granados ◽  
Mónica Adriana Martínez Ramírez ◽  
Edgardo Reyes ◽  
Guillermo Feria-Bernal ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Genetic Variants ◽  
Mitochondrial Genes ◽  
Aggressive Prostate Cancer ◽  
Mexican Mestizo ◽  
Overweight Or Obesity

Association of a TFAM haplotype with aggressive prostate cancer in overweight or obese Mexican Mestizo men

2017 ◽  
Vol 35 (3) ◽  
pp. 111.e9-111.e14 ◽  
Author(s):  
Jesús Benítez Granados ◽  
Juan Pablo Méndez ◽  
Guillermo Feria-Bernal ◽  
Eduardo García-García ◽  
María Elena Tejeda ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Aggressive Prostate Cancer ◽  
Mexican Mestizo

464: Is Obesity Associated with more Aggressive Prostate Cancer? (Data from Capsure)

2004 ◽  
Vol 171 (4S) ◽  
pp. 124-124 ◽  
Author(s):  
Christopher J. Kane ◽  
William W. Bassett ◽  
Natalia Sadetsky ◽  
Stephanie J. Silva ◽  
David J. Pasta ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Aggressive Prostate Cancer ◽  
Cancer Data

1414: Aggressive Prostate Cancer is Associated with Nucleotide Variants of the Semaphorin 3F Gene

2005 ◽  
Vol 173 (4S) ◽  
pp. 383-383
Author(s):  
Susan L. Naylor ◽  
Xin He ◽  
RuiHua Xiang ◽  
Dawn K. Garcia ◽  
Edith D. Canby-Hagino ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Aggressive Prostate Cancer ◽  
Semaphorin 3F

scholarly journals Rare Germline Pathogenic Variants Identified by Multigene Panel Testing and the Risk of Aggressive Prostate Cancer

Cancers ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1495
Author(s):  
Tú Nguyen-Dumont ◽  
James G. Dowty ◽  
Robert J. MacInnis ◽  
Jason A. Steen ◽  
Moeen Riaz ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Risk Prediction ◽  
Prediction Models ◽  
Risk Prediction Models ◽  
Aggressive Prostate Cancer ◽  
Panel Testing ◽  
Pathogenic Variants ◽  
Increased Risk ◽  
Predisposition Genes ◽  
Rare Genetic Variants

While gene panel sequencing is becoming widely used for cancer risk prediction, its clinical utility with respect to predicting aggressive prostate cancer (PrCa) is limited by our current understanding of the genetic risk factors associated with predisposition to this potentially lethal disease phenotype. This study included 837 men diagnosed with aggressive PrCa and 7261 controls (unaffected men and men who did not meet criteria for aggressive PrCa). Rare germline pathogenic variants (including likely pathogenic variants) were identified by targeted sequencing of 26 known or putative cancer predisposition genes. We found that 85 (10%) men with aggressive PrCa and 265 (4%) controls carried a pathogenic variant (p < 0.0001). Aggressive PrCa odds ratios (ORs) were estimated using unconditional logistic regression. Increased risk of aggressive PrCa (OR (95% confidence interval)) was identified for pathogenic variants in BRCA2 (5.8 (2.7–12.4)), BRCA1 (5.5 (1.8–16.6)), and ATM (3.8 (1.6–9.1)). Our study provides further evidence that rare germline pathogenic variants in these genes are associated with increased risk of this aggressive, clinically relevant subset of PrCa. These rare genetic variants could be incorporated into risk prediction models to improve their precision to identify men at highest risk of aggressive prostate cancer and be used to identify men with newly diagnosed prostate cancer who require urgent treatment.

Sign in / Sign up

Export Citation Format

Share Document