Gene environment interaction in urinary bladder cancer with special reference to organochlorine pesticide: A case control study

2013 ◽  
Vol 13 (4) ◽  
pp. 243-251 ◽  
Author(s):  
Tusha Sharma ◽  
Smita Jain ◽  
Ankur Verma ◽  
Nivedita Sharma ◽  
Sanjay Gupta ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Urinary Bladder ◽  
Special Reference ◽  
Case Control Study ◽  
Urinary Bladder Cancer ◽  
Case Control ◽  
Environment Interaction ◽  
Gene Environment Interaction ◽  
Gene Environment ◽  
Control Study

Association Between Tfeb Gene Polymorphism, Gene–environment Interaction, and Fatty Liver Disease: a Case–control Study in China

2021 ◽  
Author(s):  
Chunbao Mo ◽  
Tingyu Mai ◽  
Jiansheng Cai ◽  
Haoyu He ◽  
Huaxiang Lu ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Case Control Study ◽  
Case Control ◽  
Environment Interaction ◽  
Additive Interaction ◽  
Gene Environment Interaction ◽  
Gene Environment ◽  
Control Study

Abstract Background: Fatty liver disease (FLD) is a serious public health problem that is rapidly increasing. Evidences indicated that the transcription factor EB (TFEB) gene may be involved in the pathophysiology of FLD; however, whether TEFB polymorphism is association with FLD remains unclear.Objectives: To explore the association among TFEB polymorphism, gene–environment interaction, and FLD and provide epidemiological evidence for clarifying the genetic factors of FLD.Methods: This study is a case–control study. Sequenom MassARRAY was applied in genotyping. Logical regression was used to analyze the association between TFEB polymorphism and FLD, and the gene–environment interaction in FLD was evaluated by multiplication and additive interaction models.Results: (1) The alleles and genotypes of each single nucleotide polymorphism of TFEB in the case and control groups were evenly distributed; no statistically substantial difference was observed. (2) Logistic regression analysis indicated that TFEB polymorphism is not remarkably associated with FLD. (3) In the multiplicative interaction model, rs1015149, rs1062966, and rs11754668 had remarkable interaction with smoking amount. Rs1062966 and rs11754668 also had a considerable interaction with body mass index and alcohol intake, respectively. However, no remarkable additive interaction was observed.Conclusion: TFEB polymorphism is not directly associated with FLD susceptibility, but the risk can be changed through gene–environment interaction.

Air pollution and risk of urinary bladder cancer in a case-control study in Spain

2008 ◽  
Vol 65 (1) ◽  
pp. 56-60 ◽  
Author(s):  
G. Castano-Vinyals ◽  
K. P Cantor ◽  
N. Malats ◽  
A. Tardon ◽  
R. Garcia-Closas ◽  
...  
Keyword(s):  
Air Pollution ◽  
Bladder Cancer ◽  
Urinary Bladder ◽  
Case Control Study ◽  
Urinary Bladder Cancer ◽  
Case Control ◽  
Control Study

scholarly journals Association between TFEB gene polymorphism, gene–environment interaction, and fatty liver disease: A case–control study in China

2021 ◽  
Vol 104 (3) ◽  
pp. 003685042110437
Author(s):  
Chunbao Mo ◽  
Tingyu Mai ◽  
Jiansheng Cai ◽  
Haoyu He ◽  
Huaxiang Lu ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Case Control Study ◽  
Case Control ◽  
Environment Interaction ◽  
Additive Interaction ◽  
Gene Environment Interaction ◽  
Gene Environment ◽  
Control Study

Background: Fatty liver disease (FLD) is a serious public health problem that is rapidly increasing. Evidence indicates that the transcription factor EB ( TFEB) gene may be involved in the pathophysiology of FLD; however, whether TEFB polymorphism has an association with FLD remains unclear. Objectives: To explore the association among TFEB polymorphism, gene–environment interaction, and FLD and provide epidemiological evidence for clarifying the genetic factors of FLD. Methods: This study is a case–control study. Sequenom MassARRAY was applied in genotyping. Logical regression was used to analyze the association between TFEB polymorphism and FLD, and the gene–environment interaction in FLD was evaluated by multiplication and additive interaction models. Results: (1) The alleles and genotypes of each single nucleotide polymorphism and haplotypes of TFEB in the case and control groups were evenly distributed; no statistically substantial difference was observed. (2) Logistic regression analysis indicated that TFEB polymorphism is not remarkably associated with FLD. (3) In the multiplicative interaction model, rs1015149, rs1062966, rs11754668 and rs2273068 had remarkable interaction with the amount of cigarette smoking. Rs1062966 and rs11754668 also had a considerable interaction body mass index and alcohol intake, respectively. However, no remarkable additive interaction was observed. Conclusion: TFEB polymorphism is not directly associated with FLD susceptibility, but the risk can be changed through gene–environment interaction.

scholarly journals Urinary Bladder Cancer Risk Factors in Egypt: A Multicenter Case–Control Study

2011 ◽  
Vol 21 (3) ◽  
pp. 537-546 ◽  
Author(s):  
Yun-Ling Zheng ◽  
Sania Amr ◽  
Doa'a A. Saleh ◽  
Chiranjeev Dash ◽  
Sameera Ezzat ◽  
...  
Keyword(s):  
Risk Factors ◽  
Bladder Cancer ◽  
Urinary Bladder ◽  
Cancer Risk ◽  
Case Control Study ◽  
Urinary Bladder Cancer ◽  
Case Control ◽  
Bladder Cancer Risk ◽  
Cancer Risk Factors ◽  
Control Study

scholarly journals Sequence Variant on 3q28 and Urinary Bladder Cancer Risk: Findings from the Los Angeles-Shanghai Bladder Case-Control Study

2009 ◽  
Vol 18 (11) ◽  
pp. 3057-3061 ◽  
Author(s):  
Mariana C. Stern ◽  
David Van Den Berg ◽  
Jian-Min Yuan ◽  
David V. Conti ◽  
Manuela Gago-Dominguez ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Los Angeles ◽  
Urinary Bladder ◽  
Cancer Risk ◽  
Case Control Study ◽  
Urinary Bladder Cancer ◽  
Case Control ◽  
Sequence Variant ◽  
Bladder Cancer Risk ◽  
Control Study
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