Quartz crystal microbalance with dissipation monitoring and the real-time study of biological systems and macromolecules at interfaces

2012 ◽  
Vol 1 (4) ◽  
pp. 325-338 ◽  
Author(s):  
Alessio Ausili ◽  
Mattias Berglin ◽  
Hans Elwing ◽  
Senena Corbalán-García ◽  
Juan C. Gómez-Fernández
Keyword(s):  
Real Time ◽  
Quartz Crystal Microbalance ◽  
Quartz Crystal ◽  
Biological Systems ◽  
Time Study ◽  
The Real

scholarly journals Deconvoluting and Quantifying the Real-time Fluxes and Ionic Currents of Various Species Using In Situ Electrochemical Quartz Crystal Microbalance Measurements

2021 ◽  
Author(s):  
Kai Zheng ◽  
Yongqiu Xian ◽  
Zifeng LIN
Keyword(s):  
Real Time ◽  
Quartz Crystal Microbalance ◽  
Quartz Crystal ◽  
Ionic Current ◽  
Ionic Currents ◽  
Electrochemical Quartz Crystal Microbalance ◽  
Cyclic Voltammograms ◽  
Supercapacitor Electrode ◽  
The Real ◽  
Porous Carbon Electrode

Electrochemical quartz crystal microbalance (EQCM) is a powerful technique to screen the gravimetric response of electrochemical electrodes. In this study, a straightforward mathematical method is proposed for extracting and deconvoluting the real-time fluxes and ionic currents of two species based on the EQCM measurement results. We creatively propose the concept of flux cyclic voltammograms (CVs) and ionic current CVs of various species and apply them to the real-time analyses of molecules/ions dynamics. For proof of concept, Ti3C2Tx MXene, a most studied two-dimensional metal carbide, is investigated as a supercapacitor electrode in a 1M H2SO4 electrolyte. The H2O and H+ flux CV plots are highly symmetrical, indicating reversible inserting/deserting species fluxes. The highest fluxes along with maximum hydration numbers are obtained at the peak current potential. This suggests the significant contribution of double-layer capacitance originates from the insertion of hydrated H+. The H+ CV with the ionic current induced by H+ flux overlaps the real CV, confirming that H+ is the only interactive ion for screening the electrode charge. Lastly, we also validate the proposed strategy using Ti3C2Tx MXene electrode in 1M KCl electrolyte and YP80 porous carbon electrode in 1 M LiCl electrolyte.

Quartz Crystal Microbalance monitoring the real-time binding of lectin with carbohydrate with high and low molecular mass

2008 ◽  
Vol 89 (2) ◽  
pp. 153-158 ◽  
Author(s):  
Mariele M. Pedroso ◽  
Ailton M. Watanabe ◽  
Maria Cristina Roque-Barreira ◽  
Paulo R. Bueno ◽  
Ronaldo C. Faria
Keyword(s):  
Molecular Mass ◽  
Real Time ◽  
Quartz Crystal Microbalance ◽  
Quartz Crystal ◽  
The Real

scholarly journals A Real-Time Method for Improving Stability of Monolithic Quartz Crystal Microbalance Operating under Harsh Environmental Conditions

Sensors ◽  
2021 ◽  
Vol 21 (12) ◽  
pp. 4166
Author(s):  
Román Fernández ◽  
María Calero ◽  
Yolanda Jiménez ◽  
Antonio Arnau
Keyword(s):  
Real Time ◽  
Quartz Crystal Microbalance ◽  
Quartz Crystal ◽  
Limit Of Detection ◽  
Quartz Substrate ◽  
Low Cost ◽  
Discrete Wavelet ◽  
Reagent Consumption ◽  
Measurement Cell ◽  
The Stability

Monolithic quartz crystal microbalance (MQCM) has recently emerged as a very promising technology suitable for biosensing applications. These devices consist of an array of miniaturized QCM sensors integrated within the same quartz substrate capable of detecting multiple target analytes simultaneously. Their relevant benefits include high throughput, low cost per sensor unit, low sample/reagent consumption and fast sensing response. Despite the great potential of MQCM, unwanted environmental factors (e.g., temperature, humidity, vibrations, or pressure) and perturbations intrinsic to the sensor setup (e.g., mechanical stress exerted by the measurement cell or electronic noise of the characterization system) can affect sensor stability, masking the signal of interest and degrading the limit of detection (LoD). Here, we present a method based on the discrete wavelet transform (DWT) to improve the stability of the resonance frequency and dissipation signals in real time. The method takes advantage of the similarity among the noise patterns of the resonators integrated in an MQCM device to mitigate disturbing factors that impact on sensor response. Performance of the method is validated by studying the adsorption of proteins (neutravidin and biotinylated albumin) under external controlled factors (temperature and pressure/flow rate) that simulate unwanted disturbances.

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