scholarly journals Exercise in a Pill: The Latest on Exercise-Mimetics

2017 ◽  
Vol 2 (2) ◽  
pp. 153-169 ◽  
Author(s):  
Davide Guerrieri ◽  
Hyo Youl Moon ◽  
Henriette van Praag
Keyword(s):  
Exercise Mimetics

scholarly journals AdipoR agonist increases insulin sensitivity and exercise endurance in AdipoR-humanized mice

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Masato Iwabu ◽  
Miki Okada-Iwabu ◽  
Hiroaki Tanabe ◽  
Nozomi Ohuchi ◽  
Keiko Miyata ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Treadmill Exercise ◽  
Humanized Mice ◽  
Diabetic Mice ◽  
Double Knockout ◽  
Specific Expression ◽  
Beneficial Effects ◽  
Exercise Mimetics ◽  
Exercise Endurance ◽  
And Oxidative Stress

AbstractAdiponectin receptors, AdipoR1 and AdipoR2 exert anti-diabetic effects. Although muscle-specific disruption of AdipoR1 has been shown to result in decreased insulin sensitivity and decreased exercise endurance, it remains to be determined whether upregulation of AdipoR1 could reverse them in obese diabetic mice. Here, we show that muscle-specific expression of human AdipoR1 increased expression levels of genes involved in mitochondrial biogenesis and oxidative stress-detoxification to almost the same extents as treadmill exercise, and concomitantly increased insulin sensitivity and exercise endurance in obese diabetic mice. Moreover, we created AdipoR-humanized mice which express human AdipoR1 in muscle of AdipoR1·R2 double-knockout mice. Most importantly, the small-molecule AdipoR agonist AdipoRon could exert its beneficial effects in muscle via human AdipoR, and increased insulin sensitivity and exercise endurance in AdipoR-humanized mice. This study suggests that expression of human AdipoR1 in skeletal muscle could be exercise-mimetics, and that AdipoRon could exert its beneficial effects via human AdipoR1.

scholarly journals Will exercise mimetics hold promise?

2015 ◽  
Vol 03 (02) ◽  
Author(s):  
Dario Coletti Sergio Adamo
Keyword(s):  
Exercise Mimetics

scholarly journals Can Exercise Mimetics Substitute for Exercise?

2008 ◽  
Vol 8 (2) ◽  
pp. 96-98 ◽  
Author(s):  
Erik A. Richter ◽  
Bente Kiens ◽  
Jørgen F.P. Wojtaszewski
Keyword(s):  
Exercise Mimetics

scholarly journals PHARMACOLOGICAL EXERCISE MIMETICS IN THERAPY: DELUSION OR FUTURE?

2013 ◽  
pp. 58-62
Author(s):  
Biljana Vitošević ◽  
Jasmina Ranković ◽  
Nebojša R. Mitić ◽  
Ljiljana Popović ◽  
Gorana Ranković Nedin
Keyword(s):  
Exercise Mimetics
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