Scaffolds of bioactive glass-ceramic (Biosilicate®) and bone healing: A biological evaluation in an experimental model of tibial bone defect in rats

2018 ◽  
Vol 29 (5) ◽  
pp. 665-683 ◽  
Author(s):  
Karina Nogueira Zambone Pinto ◽  
Carla Roberta Tim ◽  
Murilo Camuri Crovace ◽  
Bruno Rafael Orsini Rossi ◽  
Hueliton Wilian Kido ◽  
...  
Keyword(s):  
Bioactive Glass ◽  
Experimental Model ◽  
Bone Defect ◽  
Bone Healing ◽  
Glass Ceramic ◽  
Biological Evaluation ◽  
Tibial Bone

The effect of glass-ceramic implants on matrix vesicle calcification after two weeks of rat tibial bone healing

1990 ◽  
Vol 24 (12) ◽  
pp. 1571-1584 ◽  
Author(s):  
C. Müller-Mai ◽  
D. Amir ◽  
H. Wendland ◽  
Z. Schwartz ◽  
J. Sela ◽  
...  
Keyword(s):  
Bone Healing ◽  
Glass Ceramic ◽  
Matrix Vesicle ◽  
Tibial Bone ◽  
Ceramic Implants

Evaluation of the bone healing process in an experimental tibial bone defect model in ovariectomized rats

2014 ◽  
Vol 26 (5) ◽  
pp. 473-481 ◽  
Author(s):  
Hueliton Wilian Kido ◽  
Paulo Sérgio Bossini ◽  
Carla Roberta Tim ◽  
Nivaldo Antônio Parizotto ◽  
Anderson Ferreira da Cunha ◽  
...  
Keyword(s):  
Bone Defect ◽  
Bone Healing ◽  
Healing Process ◽  
Ovariectomized Rats ◽  
Defect Model ◽  
Tibial Bone ◽  
Bone Healing Process

Effect of glass ceramic and titanium implants on primary calcification during rat tibial bone healing

1991 ◽  
Vol 49 (5) ◽  
pp. 359-364 ◽  
Author(s):  
Z. Schwartz ◽  
D. Amir ◽  
Barbara D. Boyan ◽  
D. Cochavy ◽  
C. Muller Mai ◽  
...  
Keyword(s):  
Bone Healing ◽  
Glass Ceramic ◽  
Titanium Implants ◽  
Tibial Bone

Biological evaluation of the bone healing process after application of two potentially osteogenic proteins: an animal experimental model

Gerodontology ◽  
2012 ◽  
Vol 29 (4) ◽  
pp. 258-264 ◽  
Author(s):  
João P. M. Issa ◽  
Helton L. A. Defino ◽  
Walter Sebald ◽  
Joaquim Coutinho-Netto ◽  
Mamie M. Iyomasa ◽  
...  
Keyword(s):  
Experimental Model ◽  
Bone Healing ◽  
Healing Process ◽  
Biological Evaluation ◽  
Bone Healing Process ◽  
Animal Experimental Model

Structural and in vitro biological evaluation of sol-gel derived multifunctional Ti+4/Sr+2 co-doped bioactive glass with enhanced properties for bone healing

2021 ◽  
Author(s):  
Amirhossein Moghanian ◽  
Saba Nasiripour ◽  
Zahra Miri ◽  
Zeinab Hajifathali ◽  
Seyed Hesamedin Hosseini ◽  
...  
Keyword(s):  
Bioactive Glass ◽  
Bone Healing ◽  
Sol Gel ◽  
Biological Evaluation ◽  
Enhanced Properties ◽  
Co Doped

Surface Modification of Apatite-wollastonite Bioactive Glass-ceramic by Grafting with RGD Peptides

2013 ◽  
Vol 28 (10) ◽  
pp. 1137-1142
Author(s):  
Xiang ZHANG ◽  
Da-Li ZHOU ◽  
Qin LONG ◽  
Jia-Bei ZHOU ◽  
Yan-Fei TAN ◽  
...  
Keyword(s):  
Surface Modification ◽  
Bioactive Glass ◽  
Glass Ceramic ◽  
Rgd Peptides

scholarly journals Application of subject-specific adaptive mechanical loading for bone healing in a mouse tail vertebral defect

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Angad Malhotra ◽  
Matthias Walle ◽  
Graeme R. Paul ◽  
Gisela A. Kuhn ◽  
Ralph Müller
Keyword(s):  
Mechanical Loading ◽  
Bone Defect ◽  
Bone Healing ◽  
Three Dimensional ◽  
Patient Specific ◽  
Dependent Manner ◽  
Micro Computed Tomography ◽  
Computed Tomography Images ◽  
Bone Defect Healing ◽  
Subject Specific

AbstractMethods to repair bone defects arising from trauma, resection, or disease, continue to be sought after. Cyclic mechanical loading is well established to influence bone (re)modelling activity, in which bone formation and resorption are correlated to micro-scale strain. Based on this, the application of mechanical stimulation across a bone defect could improve healing. However, if ignoring the mechanical integrity of defected bone, loading regimes have a high potential to either cause damage or be ineffective. This study explores real-time finite element (rtFE) methods that use three-dimensional structural analyses from micro-computed tomography images to estimate effective peak cyclic loads in a subject-specific and time-dependent manner. It demonstrates the concept in a cyclically loaded mouse caudal vertebral bone defect model. Using rtFE analysis combined with adaptive mechanical loading, mouse bone healing was significantly improved over non-loaded controls, with no incidence of vertebral fractures. Such rtFE-driven adaptive loading regimes demonstrated here could be relevant to clinical bone defect healing scenarios, where mechanical loading can become patient-specific and more efficacious. This is achieved by accounting for initial bone defect conditions and spatio-temporal healing, both being factors that are always unique to the patient.

Ag-doped Bioactive Glass-Ceramic 3D Scaffolds: Microstructural, Antibacterial, and Biological Properties

2021 ◽  
Author(s):  
Adam C. Marsh ◽  
Nathan P. Mellott ◽  
Martin Crimp ◽  
Anthony Wren ◽  
Neal Hammer ◽  
...  
Keyword(s):  
Bioactive Glass ◽  
Glass Ceramic ◽  
Biological Properties ◽  
3D Scaffolds

scholarly journals Unprecedented tibial bone lengthening of 33.5 cm by distraction osteogenesis for the reconstruction of a subtotal tibial bone defect. A case report and literature review

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Abdulnassir Ali ◽  
Ying Ren ◽  
Chun-Hao Zhou ◽  
Jia Fang ◽  
Cheng-He Qin
Keyword(s):  
Bone Defect ◽  
Distraction Osteogenesis ◽  
Chronic Osteomyelitis ◽  
Weight Bearing ◽  
Lower Leg ◽  
Bone Lengthening ◽  
Case Presentation ◽  
Tibial Length ◽  
Tibial Bone ◽  
The Right

Abstract Background We present a case of an immense unprecedented tibial bone lengthening of 33.5 cm. The management of chronic osteomyelitis of the right tibia with subtotal tibial bone defect, talus defect and equinus ankle deformity. We demonstrate limb reconstruction by distraction osteogenesis and correction of ankle deformity with the Ilizarov technique. Limb salvage was preferred as an alternative to amputation to restore basic limb function. Case presentation A 16-year-old male patient fell and injured his right lower leg. He attempted to treat the symptoms with traditional home remedies. During 15 months of self-treating, he developed osteomyelitis of the right tibia and had lost function in his foot. Radiology revealed immense bone defect of the right tibia, including talus bone defect and equinus deformity of the calcaneus. The patient’s right tibia was non weight-bearing, had drainage sinus just below his knee and a large scar anteriorly along the entire length of the tibia. Conclusion Upon completion of treatment, the patient was able to avoid amputation of his leg with partially restored function for weight-bearing. He carried himself without assistance after 3 years of lost function in his right leg. Tibial bone distraction osteogenesis of 33.5 cm was done after 90% of the tibial length was defected. To the best of our best knowledge, this case is one of a kind to achieve distraction of tibial bone to such length.

scholarly journals Leucocyte- and Platelet-Rich Fibrin Block: Its Use for the Treatment of a Large Cyst with Implant-Based Rehabilitation

Medicina ◽  
2021 ◽  
Vol 57 (2) ◽  
pp. 180 ◽  
Author(s):  
Rodolfo Mauceri ◽  
Denise Murgia ◽  
Orazio Cicero ◽  
Luigi Paternò ◽  
Luca Fiorillo ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Bone Defect ◽  
Bone Healing ◽  
Bone Substitute ◽  
Alveolar Bone ◽  
Critical Size ◽  
Large Bone ◽  
Alveolar Bone Defect ◽  
Positive Results ◽  
Autologous Platelet

The management of critical-size bone defects is still demanding. Recently, autologous platelet concentrates in combination with bone substitute have been applied and reported in a few studies. Our aim is to report the healing of a critical-size alveolar bone defect treated with a new bone regeneration technique by means of L-PRF and L-PRF blocks. A 45-year-old woman presented a large cystic lesion; the extraction of three teeth, a cyst removal procedure, and bone regeneration procedures with L-PRF and L-PRF blocks were planned. The L-PRF block was prepared by mixing a bone substitute with a piece of L-PRF membrane and liquid fibrinogen. Additionally, after bone healing an implant-based rehabilitation was optimally performed. On the basis of the positive results, in terms of bone healing and tissue regeneration in a large bone defect, the application of L-PRF and L-PRF blocks, in agreement with the scarce literature, is suggested as a feasible procedure in selected cases.

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