Effect of lanthanides on red blood cell deformability and response to mechanical stress: Role of lanthanide ionic radius

Biorheology ◽  
2011 ◽  
Vol 48 (3-4) ◽  
pp. 173-183 ◽  
Author(s):  
Tamas Alexy ◽  
Oguz K. Baskurt ◽  
Norbert Nemeth ◽  
Mehmet Uyuklu ◽  
Rosalinda B. Wenby ◽  
...  
Keyword(s):  
Blood Cell ◽  
Mechanical Stress ◽  
Red Blood Cell ◽  
Ionic Radius ◽  
Cell Deformability ◽  
Red Blood Cell Deformability

scholarly journals Regulation of red blood cell filterability by Ca2+ influx and cAMP-mediated signaling pathways

1997 ◽  
Vol 273 (6) ◽  
pp. C1828-C1834 ◽  
Author(s):  
Tadahiro Oonishi ◽  
Kanako Sakashita ◽  
Nobuhiro Uyesaka
Keyword(s):  
Blood Cell ◽  
Red Blood Cells ◽  
Signaling Pathways ◽  
Mechanical Stress ◽  
Red Blood Cell ◽  
Blood Cells ◽  
Camp Level ◽  
Membrane Properties ◽  
Cell Deformability ◽  
Red Blood Cell Deformability

To investigate the mechanism of the regulation of human red blood cell deformability, we examined the deformability under mechanical stress. Washed human red blood cells were rapidly injected through a fine needle, and their filterability was measured using a nickel mesh filter. The decrease in filterability showed a V-shaped curve depending on the extracellular Ca2+ concentration; the maximum decrease was achieved at ∼50 μM. The decreased filterability was accompanied by no change in cell morphology and cell volume, indicating that the decrease in filterability can be ascribed to alterations of the membrane properties. Ca2+entry blockers (nifedipine and felodipine) inhibited the impairment of filterability under mechanical stress. Prostaglandins E1 and E2, epinephrine, and pentoxifylline, which are thought to modulate the intracellular adenosine 3′,5′-cyclic monophosphate (cAMP) level of red blood cells, improved or worsened the impaired filterability according to their expected actions on the cAMP level of the cells. These results strongly suggest that the membrane properties regulating red blood cell deformability are affected by the signal transduction system, including Ca2+-dependent and cAMP-mediated signaling pathways.

The Role of Cytoskeletal S-Nitrosation in Red Blood Cell Deformability

2016 ◽  
Vol 100 ◽  
pp. S140
Author(s):  
Lukas Dominik Diederich ◽  
Thomas C. Stevenson Keller IV ◽  
Wiebke Lückstädt ◽  
Markus Dick ◽  
Malte Kelm ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Cell Deformability ◽  
Red Blood Cell Deformability

P038. The role of nitric oxide in regulation of red blood cell deformability

Nitric Oxide ◽  
2006 ◽  
Vol 14 (4) ◽  
pp. 30
Author(s):  
Xiaojun He ◽  
Ivan Azarov ◽  
Daniel B. Kim-Shapiro
Keyword(s):  
Nitric Oxide ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Cell Deformability ◽  
Red Blood Cell Deformability

Decrease in Red Blood Cell Deformability Caused by Hypothermia, Hemodilution, and Mechanical Stress

ASAIO Journal ◽  
1999 ◽  
Vol 45 (4) ◽  
pp. 307-310 ◽  
Author(s):  
MARINA V. KAMENEVA ◽  
AKIF ÜNDAR ◽  
JAMES F. ANTAKI ◽  
MARY J. WATACH ◽  
JOHN H. CALHOON ◽  
...  
Keyword(s):  
Blood Cell ◽  
Mechanical Stress ◽  
Red Blood Cell ◽  
Cell Deformability ◽  
Red Blood Cell Deformability

scholarly journals Non-Occlusive Retinal Vascular Inflammation and Role of Red Blood Cell Deformability in Birdshot Chorioretinopathy

2018 ◽  
Vol 27 (6) ◽  
pp. 978-986
Author(s):  
Rupesh Agrawal ◽  
Bryan Ang ◽  
Praveen Kumar Balne ◽  
Christopher Richards ◽  
Thomas Smart ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Vascular Inflammation ◽  
Cell Deformability ◽  
Birdshot Chorioretinopathy ◽  
Red Blood Cell Deformability

scholarly journals Multiplexed fluidic plunger mechanism for the measurement of red blood cell deformability

Lab on a Chip ◽  
2015 ◽  
Vol 15 (1) ◽  
pp. 159-167 ◽  
Author(s):  
Marie-Eve Myrand-Lapierre ◽  
Xiaoyan Deng ◽  
Richard R. Ang ◽  
Kerryn Matthews ◽  
Aline T. Santoso ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Cell Deformability ◽  
Heterogeneous Sample ◽  
Red Blood Cell Deformability

Mechanism for multiplexed measurement of single red blood cell deformability to evaluate pathological cells in a heterogeneous sample.

Limited effects of activated protein C on red blood cell deformability

2013 ◽  
Vol 53 (4) ◽  
pp. 387-391 ◽  
Author(s):  
Michael Piagnerelli ◽  
Hassane Njimi ◽  
Tatiana Veloso Coelho ◽  
Giulia Reggiori ◽  
Diego Castanares Zapatero ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Protein C ◽  
Activated Protein C ◽  
Cell Deformability ◽  
Red Blood Cell Deformability
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