scholarly journals Babesia crassa–Like Human Infection Indicating Need for Adapted PCR Diagnosis of Babesiosis, France

2022 ◽  
Vol 28 (2) ◽  
Author(s):  
Cécile Doderer-Lang ◽  
Denis Filisetti ◽  
Julie Badin ◽  
Charles Delale ◽  
Victoria Clavier ◽  
...  
Keyword(s):  
Human Infection ◽  
Pcr Diagnosis

Human infection with Dirofilaria

1978 ◽  
Vol 114 (4) ◽  
pp. 593-594 ◽  
Author(s):  
H. M. Payan
Keyword(s):  
Human Infection

A case of natural human infection by Echinostoma cinetorchis

1988 ◽  
Vol 26 (1) ◽  
pp. 61 ◽  
Author(s):  
Sang Kum Lee ◽  
Nak Seung Chung ◽  
Ill Hyang Ko ◽  
Haeng Ill Ko ◽  
Woon Mok Sohn
Keyword(s):  
Human Infection

Second case of human infection with Mesocestoides lineatus in Korea

1992 ◽  
Vol 30 (2) ◽  
pp. 147 ◽  
Author(s):  
K S Eom ◽  
S H Kim ◽  
H J Rim
Keyword(s):  
Human Infection

Human Infection with Fungi, Actinomycetes and Algae

1971 ◽  
Author(s):  
Roger Denio Baker ◽  
Alberto Angulo O. ◽  
Cesar Barroso-Tobila ◽  
Luis M. Carbonell ◽  
Rodolfo Céspedes F. ◽  
...  
Keyword(s):  
Human Infection

Identification of a novel CBFB-MYH11 transcript: implications for RT–PCR diagnosis

2001 ◽  
Vol 2 (3) ◽  
pp. 206-209 ◽  
Author(s):  
Bert A Van der Reijden ◽  
Linda de Wit ◽  
Sonja van der Poel ◽  
Erna B Luiten ◽  
Marina Lafage-Pochitaloff ◽  
...  
Keyword(s):  
Rt Pcr ◽  
Pcr Diagnosis

scholarly journals Immune Serum Produced by DNA Vaccination Protects Hamsters against Lethal Respiratory Challenge with Andes Virus

2007 ◽  
Vol 82 (3) ◽  
pp. 1332-1338 ◽  
Author(s):  
Jay W. Hooper ◽  
Anthony M. Ferro ◽  
Victoria Wahl-Jensen
Keyword(s):  
Dna Vaccine ◽  
Neutralizing Antibodies ◽  
Lethal Dose ◽  
Case Fatality ◽  
Immune Serum ◽  
Human Infection ◽  
M Gene ◽  
Hamster Model ◽  
Highly Pathogenic ◽  
Andes Virus

ABSTRACT Hantavirus pulmonary syndrome (HPS) is a highly pathogenic disease (40% case fatality rate) carried by rodents chronically infected with certain viruses within the genus Hantavirus of the family Bunyaviridae. The primary mode of transmission to humans is thought to be inhalation of excreta from infected rodents; however, ingestion of contaminated material and rodent bites are also possible modes of transmission. Person-to-person transmission of HPS caused by one species of hantavirus, Andes virus (ANDV), has been reported. Previously, we reported that ANDV injected intramuscularly causes a disease in Syrian hamsters that closely resembles HPS in humans. Here we tested whether ANDV was lethal in hamsters when it was administered by routes that more accurately model the most common routes of human infection, i.e., the subcutaneous, intranasal, and intragastric routes. We discovered that ANDV was lethal by all three routes. Remarkably, even at very low doses, ANDV was highly pathogenic when it was introduced by the mucosal routes (50% lethal dose [LD50], ∼100 PFU). We performed passive transfer experiments to test the capacity of neutralizing antibodies to protect against lethal intranasal challenge. The neutralizing antibodies used in these experiments were produced in rabbits vaccinated by electroporation with a previously described ANDV M gene-based DNA vaccine, pWRG/AND-M. Hamsters that were administered immune serum on days −1 and +5 relative to challenge were protected against intranasal challenge (21 LD50). These findings demonstrate the utility of using the ANDV hamster model to study transmission across mucosal barriers and provide evidence that neutralizing antibodies produced by DNA vaccine technology can be used to protect against challenge by the respiratory route.

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