scholarly journals Neurologic Disease after Yellow Fever Vaccination, São Paulo, Brazil, 2017–2018

2021 ◽  
Vol 27 (6) ◽  
Author(s):  
Ana Freitas Ribeiro ◽  
Bruno Fukelmann Guedes ◽  
Jamal M.A.H. Sulleiman ◽  
Francisco Tomaz Meneses de Oliveira ◽  
Izabel Oliva Marcilio de Souza ◽  
...  
Keyword(s):  
Yellow Fever ◽  
Sao Paulo ◽  
Neurologic Disease ◽  
São Paulo ◽  
Yellow Fever Vaccination

scholarly journals Municipalities of higher vulnerability to Sylvatic Yellow Fever occurrence in the São Paulo State, Brazil

2011 ◽  
Vol 53 (6) ◽  
pp. 335-339 ◽  
Author(s):  
Eduardo Stramandinoli Moreno ◽  
Rita de Cássia Barradas Barata
Keyword(s):  
High Risk ◽  
Yellow Fever ◽  
Environmental Variables ◽  
Multiple Correspondence Analysis ◽  
Sao Paulo ◽  
São Paulo ◽  
Prevention Measures ◽  
Paulo State ◽  
São Paulo State ◽  
Yellow Fever Vaccination

Until 1999 the endemic cases of Sylvatic Yellow Fever were located in the states of northern, midwestern and pre-Amazon regions. Since then, the disease progressively expanded its territory of occurrence, cases being registered beyond the traditional boundaries of endemism. The São Paulo State is considered to be part of this context, since after decades without registration of autochthonous cases of the disease, it reported, in 2000 and 2008-2009, epizootic occurrence in non-human primates and 30 cases in humans. Facts like these, added to the increase in incidences of serious adverse effects resulting from the Yellow Fever vaccination, have highlighted the importance of defining priority municipalities for vaccination against the disease in the state. Two groups of municipalities, some affected and some non-affected by YF, were compared for environmental variables related to the eco-epidemiology of the disease according to literature. The Multiple Correspondence Analysis (MCA) was used to pinpoint the factor able to differentiate the two groups of municipalities and define the levels of risk. The southeast region of the São Paulo State was considered to be the area with a higher number of municipalities classified as high risk and should be considered a priority for the application of prevention measures against Yellow Fever.

scholarly journals A public health risk assessment for yellow fever vaccination: a model exemplified by an outbreak in the state of São Paulo, Brazil

2015 ◽  
Vol 110 (2) ◽  
pp. 230-234 ◽  
Author(s):  
Ana Freitas Ribeiro ◽  
Ciléa Tengan ◽  
Helena Keico Sato ◽  
Roberta Spinola ◽  
Melissa Mascheretti ◽  
...  
Keyword(s):  
Public Health ◽  
Risk Assessment ◽  
Health Risk ◽  
Yellow Fever ◽  
Health Risk Assessment ◽  
Sao Paulo ◽  
The State ◽  
São Paulo ◽  
Public Health Risk ◽  
Yellow Fever Vaccination

scholarly journals Yellow Fever: Factors Associated with Death in a Hospital of Reference in Infectious Diseases, São Paulo, Brazil, 2018

2019 ◽  
Vol 101 (1) ◽  
pp. 180-188 ◽  
Author(s):  
Ana Freitas Ribeiro ◽  
Roberta Figueiredo Cavalin ◽  
Jamal Muhamad Abdul Hamid Suleiman ◽  
Jessica Alves da Costa ◽  
Marileide Januaria de Vasconcelos ◽  
...  
Keyword(s):  
Infectious Diseases ◽  
Yellow Fever ◽  
Sao Paulo ◽  
São Paulo ◽  
Factors Associated

scholarly journals Reemergence of yellow fever: detection of transmission in the State of São Paulo, Brazil, 2008

2011 ◽  
Vol 44 (3) ◽  
pp. 290-296 ◽  
Author(s):  
Eduardo Stramandinoli Moreno ◽  
Iray Maria Rocco ◽  
Eduardo Sterlino Bergo ◽  
Roosecelis Araujo Brasil ◽  
Melissa Mascheratti Siciliano ◽  
...  
Keyword(s):  
Cell Culture ◽  
Yellow Fever ◽  
Virus Isolation ◽  
Yellow Fever Virus ◽  
Sao Paulo ◽  
São Paulo ◽  
Rt Pcr ◽  
Epidemiological Evaluation ◽  
Entomological Research ◽  
Virus Strains

INTRODUCTION: Following yellow fever virus (YFV) isolation in monkeys from the São José do Rio Preto region and two fatal human autochthonous cases from the Ribeirão Preto region, State of São Paulo, Brazil, two expeditions for entomological research and eco-epidemiological evaluation were conducted. METHODS: A total of 577 samples from humans, 108 from monkeys and 3,049 mosquitoes were analyzed by one or more methods: virus isolation, ELISA-IgM, RT-PCR, histopathology and immunohistochemical. RESULTS: Of the 577 human samples, 531 were tested by ELISA-IgM, with 3 positives, and 235 were inoculated into mice and 199 in cell culture, resulting in one virus isolation. One sample was positive by histopathology and immunohistochemical. Using RT-PCR, 25 samples were processed with 4 positive reactions. A total of 108 specimens of monkeys were examined, 108 were inoculated into mice and 45 in cell culture. Four virus strains were isolated from Alouattacaraya. A total of 931 mosquitoes were captured in Sao Jose do Rio Preto and 2,118 in Ribeirão Preto and separated into batches. A single isolation of YFV was derived from a batch of 9 mosquitoes Psorophoraferox, collected in Urupês, Ribeirão Preto region. A serological survey was conducted with 128 samples from the municipalities of São Carlos, Rincão and Ribeirão Preto and 10 samples from contacts of patients from Ribeirão Preto. All samples were negative by ELISA-IgM for YFV. CONCLUSIONS: The results confirm the circulation of yellow fever, even though sporadic, in the Sao Paulo State and reinforce the importance of vaccination against yellow fever in areas considered at risk.

scholarly journals Genomic Surveillance of Yellow Fever Virus Epizootic in São Paulo, Brazil, 2016 – 2018

2019 ◽  
Author(s):  
S. C. Hill ◽  
R. P. de Souza ◽  
J. Thézé ◽  
I. Claro ◽  
R. S. Aguiar ◽  
...  
Keyword(s):  
Yellow Fever ◽  
Yellow Fever Virus ◽  
Sao Paulo ◽  
The State ◽  
Fever Virus ◽  
São Paulo ◽  
Paulo State ◽  
Southeast Brazil ◽  
São Paulo State ◽  
Substantial Heterogeneity

AbstractSão Paulo (SP), a densely inhabited state in southeast Brazil that contains the fourth most populated city in the world, recently experienced its largest yellow fever virus (YFV) outbreak in decades. YFV does not normally circulate extensively in SP, so most people were unvaccinated when the outbreak began. Surveillance in non-human primates (NHPs) is important for determining the magnitude and geographic extent of an epizootic, thereby helping to evaluate the risk of YFV spillover to humans. Data from infected NHPs can give more accurate insights into YFV spread than when using data from human cases alone. To contextualise human cases, identify epizootic foci and uncover the rate and direction of YFV spread in SP, we generated and analysed virus genomic data and epizootic case data from NHP in SP. We report the occurrence of three spatiotemporally distinct phases of the outbreak in SP prior to February 2018. We generated 51 new virus genomes from YFV positive cases identified in 23 different municipalities in SP, mostly sampled from non-human primates between October 2016 and January 2018. Although we observe substantial heterogeneity in lineage dispersal velocities between phylogenetic branches, continuous phylogeographic analyses of generated YFV genomes suggest that YFV lineages spread in São Paulo state at a mean rate of approximately 1km per day during all phases of the outbreak. Viral lineages from the first epizootic phase in northern São Paulo subsequently dispersed towards the south of the state to cause the second and third epizootic phases there. This alters our understanding of how YFV was introduced into the densely populated south of SP state. Our results shed light on the sylvatic transmission of yellow fever in highly fragmented forested regions in SP state and highlight the importance of continued surveillance of zoonotic pathogens in sentinel species.Author’s SummarySince July 2016, the southeast region of Brazil has experienced the largest yellow fever virus (YFV) outbreak in decades. São Paulo is the most densely populated state in southeast Brazil. The outbreak has caused serious public health concern in the state, as YFV does not normally circulate widely there and most of the 21 million inhabitants were correspondingly unvaccinated against YFV when the outbreak began. In Brazil, YFV typically circulates among non-human primates, and human cases represent isolated spillover events from this predominantly sylvatic cycle. Understanding the epidemiological dynamics and spread of YFV in non-human primates is therefore critical for contextualising human cases, and guiding vaccination strategies that can better protect local human populations. Here, we aim to contextualise human cases, identify epizootic foci and uncover the rate and direction of YFV spread in SP. We analyse the geographic and temporal distribution of observed cases of YFV in non-human primates in São Paulo state, and identify three distinct phases of the epizootic. We generate sequence data from 51 YFV-positive cases and perform phylogenetic and phylogeographic analyses aimed at understanding the spatial spread of YFV in São Paulo state. Analyses of these data indicate that YFV spread from the north of São Paulo state into more densely populated southern regions. Although we observe substantial heterogeneity in the rate at which different sampled YFV lineages spread, the typical rate of spread was low with a mean rate of ~1 km per day. This is consistent with a scenario in which the majority of transmission events occurred between non-human primates and sylvatic vectors across forested patches.Article Summary LineGenomic surveillance of yellow fever in São Paulo during the 2016-2018 epizootic

scholarly journals Dengue and the risk of urban yellow fever reintroduction in São Paulo State, Brazil

2003 ◽  
Vol 37 (4) ◽  
pp. 477-484 ◽  
Author(s):  
Eduardo Massad ◽  
Marcelo Nascimento Burattini ◽  
Francisco Antonio Bezerra Coutinho ◽  
Luiz Fernandes Lopez
Keyword(s):  
Aedes Aegypti ◽  
Yellow Fever ◽  
Reproduction Number ◽  
Sao Paulo ◽  
São Paulo ◽  
Infested Area ◽  
Paulo State ◽  
Extrinsic Incubation Period ◽  
Epidemiological Situation ◽  
Dengue Epidemic

OBJECTIVE: To propose a mathematical method for the estimation of the Basic Reproduction Number, R0, of urban yellow fever in a dengue-infested area. METHODS: The method is based on the assumption that, as the same vector (Aedes aegypti) causes both infections, all the quantities related to the mosquito, estimated from the initial phase of dengue epidemic, could be applied to yellow fever dynamics. It is demonstrated that R0 for yellow fever is, on average, 43% lower than that for dengue. This difference is due to the longer dengue viremia and its shorter extrinsic incubation period. RESULTS: In this study the analysis was expanded to the epidemiological situation of dengue in São Paulo in the year 2001. The total number of dengue cases increased from 3,582 in 2000 to 51,348 in 2001. It was then calculated R0 for yellow fever for every city which have shown R0 of dengue greater than 1. It was also estimated the total number of unprotected people living in highly risky areas for urban yellow fever. CONCLUSIONS: Currently there is a great number of non-vaccinated people living in Aedes aegypti infested area in the state of São Paulo.

scholarly journals Isolation of yellow fever virus (YFV) from naturally infectied Haemagogus (Conopostegus) leucocelaenus (diptera, cukicudae) in São Paulo State, Brazil, 2009

2011 ◽  
Vol 53 (3) ◽  
pp. 133-139 ◽  
Author(s):  
Renato Pereira de Souza ◽  
Selma Petrella ◽  
Terezinha Lisieux Moraes Coimbra ◽  
Adriana Yurika Maeda ◽  
Iray Maria Rocco ◽  
...  
Keyword(s):  
Yellow Fever ◽  
Cultured Cells ◽  
Yellow Fever Virus ◽  
Sao Paulo ◽  
Fever Virus ◽  
São Paulo ◽  
Paulo State ◽  
Virus Rna ◽  
São Paulo State ◽  
Entomological Research

After detecting the death of Howlers monkeys (genus Alouatta) and isolation of yellow fever virus (YFV) in Buri county, São Paulo, Brazil, an entomological research study in the field was started. A YFV strain was isolated from newborn Swiss mice and cultured cells of Aedes albopictus - C6/36, from a pool of six Haemagogus (Conopostegus) leucocelaenus (Hg. leucocelaenus) mosquitoes (Dyar & Shannon) collected at the study site. Virus RNA fragment was amplified by RT-PCR and sequenced. The MCC Tree generated showed that the isolated strain is related to the South American I genotype, in a monophyletic clade containing isolates from recent 2008-2010 epidemics and epizootics in Brazil. Statistical analysis commonly used were calculated to characterize the sample in relation to diversity and dominance and indicated a pattern of dominance of one or a few species. Hg. leucocelaenus was found infected in Rio Grande do Sul State as well. In São Paulo State, this is the first detection of YFV in Hg. leucocelaenus.

scholarly journals YELLOW FEVER PREVENTION STRATEGIES AWARENESS AMONG HIV-INFECTED PATIENTS IN SÃO PAULO, BRAZIL

2014 ◽  
Vol 56 (5) ◽  
pp. 417-420 ◽  
Author(s):  
Vivian Iida Avelino-Silva ◽  
Hilario Sousa Francelino ◽  
Esper Georges Kallás
Keyword(s):  
Public Health ◽  
Yellow Fever ◽  
Specific Treatment ◽  
Sao Paulo ◽  
Study Data ◽  
Health Concern ◽  
Preventive Strategy ◽  
São Paulo ◽  
Public Health Concern ◽  
Vaccine Recommendations

Introduction: Vaccination is the main preventive strategy against Yellow Fever (YF), which is a public health concern in Brazil. However, HIV-infected patients might have insufficient knowledge regarding YF, YF prevention, and vaccines in general. Methods: In this questionnaire-based study, data from 158 HIV-infected individuals were addressed in three distinct outpatient clinics in São Paulo. Information was collected on demographic and clinical characteristics, as well as patients' knowledge of vaccines, YF and YF preventive strategies. In addition, individual YF vaccine recommendations and vaccine status were investigated. Results: Although most participants adequately ascertain the vaccine as the main prevention strategy against YF, few participants were aware of the severity and lack of specific treatment for YF. Discrepancy in YF vaccine (patients who should have taken the vaccine, but did not) was observed in 18.8% of participants. Conclusion: YF is an important and preventable public health concern, and these results demonstrate that more information is necessary for the HIV-infected population.

scholarly journals The Importance of Coordinated Actions in Preventing the Spread of Yellow Fever to Human Populations: The Experience from the 2016-2017 Yellow Fever Outbreak in the Northeastern Region of São Paulo State

2019 ◽  
Vol 2019 ◽  
pp. 1-11
Author(s):  
Márcio Junio Lima Siconelli ◽  
Danillo Lucas Alves Espósito ◽  
Nathália Cristina Moraes ◽  
Julia Maria Ribeiro ◽  
Lívia Perles ◽  
...  
Keyword(s):  
Public Health ◽  
Yellow Fever ◽  
Sao Paulo ◽  
Human Populations ◽  
Hemorrhagic Disease ◽  
São Paulo ◽  
Sylvatic Cycle ◽  
Northeastern Region ◽  
Paulo State ◽  
São Paulo State

Yellow fever (YF) is a zoonotic arthropod-borne disease that is caused by the yellow fever virus (YFV) and characterized by a sylvatic and urban cycle. Its most severe presentation is manifested as a hemorrhagic disease, and it has been responsible for thousands of deaths in the last decades. This study describes the public health approaches taken to control the 2016-2017 YF outbreak in nonhuman primates (NHPs) that took place in the northeastern region of São Paulo state, Brazil. NHPs recovered from the field were necropsied, and YF diagnoses were made at the Laboratory of Molecular Virology, Ribeirão Preto Medical School and the Center of Pathology, Adolfo Lutz Institute of São Paulo. NHP samples were inoculated into Vero cells for YFV isolation. RNA extraction was performed directly from NHP tissues and tested by RT-qPCR. YFV-positive samples were confirmed by sequencing. Based on the rapid RT-qPCR results, surveillance actions were implemented in the entire region. Confirmatory histopathology and immunohistochemistry for YFV were also performed. Among nine NHPs, gross hepatic involvement was observed in six animals, five of which were YFV-RT-qPCR-positive. One YFV was isolated from the serum of an infant NHP. YFV RNA sequences diverged from the virus responsible for the last epizootic that occurred in São Paulo state, but it was similar to the current Brazilian epizootic. Public health actions included dissemination of information on YF transmission, investigation of the probable location of NHP infection, characterization of the environment, and subsequent creation of the blueprint from which prevention and control measures were implemented. The YFV sylvatic cycle occurred in the periurban areas of the northeastern region of São Paulo state, but no human cases were reported during this period, showing that integrated actions between human, animal, and environmental health professionals were critical to restrain the virus to the sylvatic cycle.

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