scholarly journals Antigenic Variant of Highly Pathogenic Avian Influenza A(H7N9) Virus, China, 2019

2020 ◽  
Vol 26 (2) ◽  
pp. 379-380 ◽  
Author(s):  
Wenming Jiang ◽  
Guangyu Hou ◽  
Jinping Li ◽  
Cheng Peng ◽  
Suchun Wang ◽  
...  
Keyword(s):  
Avian Influenza ◽  
Influenza A ◽  
Highly Pathogenic Avian Influenza ◽  
H7n9 Virus ◽  
Antigenic Variant ◽  
Highly Pathogenic ◽  
Pathogenic Avian Influenza

scholarly journals Antigenic Variant of Highly Pathogenic Avian Influenza A(H7N9) Virus, China, 2019

2020 ◽  
Vol 26 (2) ◽  
pp. 379-380 ◽  
Author(s):  
Wenming Jiang ◽  
Guangyu Hou ◽  
Jinping Li ◽  
Cheng Peng ◽  
Suchun Wang ◽  
...  
Keyword(s):  
Avian Influenza ◽  
Influenza A ◽  
Highly Pathogenic Avian Influenza ◽  
H7n9 Virus ◽  
Antigenic Variant ◽  
Highly Pathogenic ◽  
Pathogenic Avian Influenza

scholarly journals Biological characterisation of the emerged highly pathogenic avian influenza (HPAI) A(H7N9) viruses in humans, in mainland China, 2016 to 2017

2017 ◽  
Vol 22 (19) ◽  
Author(s):  
Wenfei Zhu ◽  
Jianfang Zhou ◽  
Zi Li ◽  
Lei Yang ◽  
Xiyan Li ◽  
...  
Keyword(s):  
Avian Influenza ◽  
Influenza A ◽  
Highly Pathogenic Avian Influenza ◽  
Mainland China ◽  
H7n9 Virus ◽  
Highly Pathogenic ◽  
Pathogenic Avian Influenza ◽  
Binding Preference ◽  
Severe Infections ◽  
Epidemic Wave

With no or low virulence in poultry, avian influenza A(H7N9) virus has caused severe infections in humans. In the current fifth epidemic wave, a highly pathogenic avian influenza (HPAI) H7N9 virus emerged. The insertion of four amino acids (KRTA) at the haemagglutinin (HA) cleavage site enabled trypsin-independent infectivity of this virus. Although maintaining dual receptor-binding preference, its HA antigenicity was distinct from low-pathogenic avian influenza A(H7N9). The neuraminidase substitution R292K conferred a multidrug resistance phenotype.

scholarly journals Highly Pathogenic Avian Influenza A(H7N9) Virus, Tennessee, USA, March 2017

2017 ◽  
Vol 23 (11) ◽  
pp. 1860-1863 ◽  
Author(s):  
Dong-Hun Lee ◽  
Mia K. Torchetti ◽  
Mary Lea Killian ◽  
Yohannes Berhane ◽  
David E. Swayne
Keyword(s):  
Avian Influenza ◽  
Influenza A ◽  
Highly Pathogenic Avian Influenza ◽  
H7n9 Virus ◽  
Highly Pathogenic ◽  
Pathogenic Avian Influenza

scholarly journals Epidemiology of human infections with highly pathogenic avian influenza A(H7N9) virus in Guangdong, 2016 to 2017

2017 ◽  
Vol 22 (27) ◽  
Author(s):  
Min Kang ◽  
Eric H Y Lau ◽  
Wenda Guan ◽  
Yuwei Yang ◽  
Tie Song ◽  
...  
Keyword(s):  
Risk Factor ◽  
Avian Influenza ◽  
Influenza A ◽  
Highly Pathogenic Avian Influenza ◽  
Case Fatality ◽  
H7n9 Virus ◽  
Environmental Surveillance ◽  
Highly Pathogenic ◽  
Pathogenic Avian Influenza ◽  
Human Infections

We describe the epidemiology of highly pathogenic avian influenza (HPAI) A(H7N9) based on poultry market environmental surveillance and laboratory-confirmed human cases (n = 9) in Guangdong, China. We also compare the epidemiology between human cases of high- and low-pathogenic avian influenza A(H7N9) (n = 51) in Guangdong. Case fatality and severity were similar. Touching sick or dead poultry was the most important risk factor for HPAI A(H7N9) infections and should be highlighted for the control of future influenza A(H7N9) epidemics.

scholarly journals Pathogenicity of the Novel A/H7N9 Influenza Virus in Mice

mBio ◽  
2013 ◽  
Vol 4 (4) ◽  
Author(s):  
Chris Ka Pun Mok ◽  
Horace Hok Yeung Lee ◽  
Michael Chi Wai Chan ◽  
Sin Fun Sia ◽  
Maxime Lestra ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Avian Influenza ◽  
Influenza A ◽  
H5n1 Virus ◽  
Highly Pathogenic Avian Influenza ◽  
H7n9 Virus ◽  
Highly Pathogenic ◽  
Pathogenic Avian Influenza ◽  
Hpai H5n1 ◽  
Internal Gene

ABSTRACT A novel avian-origin influenza A/H7N9 virus infecting humans was first identified in March 2013 and, as of 30 May 2013, has caused 132 human infections leading to 33 deaths. Phylogenetic studies suggest that this virus is a reassortant, with the surface hemagglutinin (HA) and neuraminidase (NA) genes being derived from duck and wild-bird viruses, respectively, while the six “internal gene segments” were derived from poultry H9N2 viruses. Here we determine the pathogenicity of a human A/Shanghai/2/2013 (Sh2/H7N9) virus in healthy adult mice in comparison with that of A/chicken/Hong Kong/HH8/2010 (ck/H9N2) virus, highly pathogenic avian influenza (HPAI) A/Hong Kong/483/1997 (483/H5N1) virus, and a duck influenza A H7N9 virus of different genetic derivation, A/duck/Jiangxi/3286/2009 (dk/H7N9). Intranasal infection of mice with Sh2/H7N9 virus doses of 103, 104, and 105 PFU led to significant weight loss without fatality. This virus was more pathogenic than dk/H7N9 and ck/H9N2 virus, which has six internal gene segments that are genetically similar to Sh2/H7N9. Sh2/H7N9 replicated well in the nasal cavity and lung, but there was no evidence of virus dissemination beyond the respiratory tract. Mice infected with Sh2/H7N9 produced higher levels of proinflammatory cytokines in the lung and serum than did ck/H9N2 and dk/H7N9 but lower levels than 483/H5N1. Cytokine induction was positively correlated with virus load in the lung at early stages of infection. Our results suggest that Sh2/H7N9 virus is able to replicate and cause disease in mice without prior adaptation but is less pathogenic than 483/H5N1 virus. IMPORTANCE An H7N9 virus isolate causing fatal human disease was found to be more pathogenic for mice than other avian H9N2 or H7N9 viruses but less pathogenic than the highly pathogenic avian influenza virus (HPAI) H5N1. Similarly, the ability of Sh2/H7N9 to elicit proinflammatory cytokines in the lung and serum of mice was intermediate to ck/H9N2 and dk/H7N9 on the one hand and HPAI H5N1 on the other. These findings accord with the observed epidemiology in humans, in whom, as with seasonal influenza viruses, H7N9 viruses cause severe disease predominantly in older persons while HPAI H5N1 can cause severe respiratory disease and death in children and young adults.

scholarly journals Westward Spread of Highly Pathogenic Avian Influenza A(H7N9) Virus among Humans, China

2018 ◽  
Vol 24 (6) ◽  
pp. 1095-1098 ◽  
Author(s):  
Qiqi Yang ◽  
Wei Shi ◽  
Lei Zhang ◽  
Yi Xu ◽  
Jing Xu ◽  
...  
Keyword(s):  
Avian Influenza ◽  
Influenza A ◽  
Highly Pathogenic Avian Influenza ◽  
H7n9 Virus ◽  
Highly Pathogenic ◽  
Pathogenic Avian Influenza
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