scholarly journals Outbreak of Tuberculosis and Multidrug-Resistant Tuberculosis, Mbuji-Mayi Central Prison, Democratic Republic of the Congo

2018 ◽  
Vol 24 (11) ◽  
pp. 2029-2035 ◽  
Author(s):  
Michel Kaswa Kayomo ◽  
Epco Hasker ◽  
Muriel Aloni ◽  
Léontine Nkuku ◽  
Marcel Kazadi ◽  
...  
Keyword(s):  
Democratic Republic ◽  
Multidrug Resistant ◽  
Resistant Tuberculosis ◽  
Multidrug Resistant Tuberculosis ◽  
Republic Of The Congo

scholarly journals Xpert Mycobacterium tuberculosis/Rifampicin–Detected Rifampicin Resistance is a Suboptimal Surrogate for Multidrug-resistant Tuberculosis in Eastern Democratic Republic of the Congo: Diagnostic and Clinical Implications

2020 ◽  
Author(s):  
Bertin C Bisimwa ◽  
Jean B Nachega ◽  
Robin M Warren ◽  
Grant Theron ◽  
John Z Metcalfe ◽  
...  
Keyword(s):  
Positive Predictive Value ◽  
Predictive Value ◽  
Democratic Republic ◽  
Multidrug Resistant ◽  
Resistance Testing ◽  
Smear Microscopy ◽  
Resistant Tuberculosis ◽  
Multidrug Resistant Tuberculosis ◽  
Mdr Tb ◽  
Republic Of The Congo

Abstract Background Rifampicin (RIF) resistance is highly correlated with isoniazid (INH) resistance and used as proxy for multidrug-resistant tuberculosis (MDR-TB). Using MTBDRplus as a comparator, we evaluated the predictive value of Xpert MTB/RIF (Xpert)–detected RIF resistance for MDR-TB in eastern Democratic Republic of the Congo (DRC). Methods We conducted a cross-sectional study involving data from new or retreatment pulmonary adult TB cases evaluated between July 2013 and December 2016. Separate, paired sputa for smear microscopy and MTBDRplus were collected. Xpert testing was performed subject to the availability of Xpert cartridges on sample remnants after microscopy. Results Among 353 patients, 193 (54.7%) were previously treated and 224 (63.5%) were MTBDRplus TB positive. Of the 224, 43 (19.2%) were RIF monoresistant, 11 (4.9%) were INH monoresistant, 53 (23.7%) had MDR-TB, and 117 (52.2%) were RIF and INH susceptible. Overall, among the 96 samples detected by MTBDRplus as RIF resistant, 53 (55.2%) had MDR-TB. Xpert testing was performed in 179 (50.7%) specimens; among these, 163 (91.1%) were TB positive and 73 (44.8%) RIF resistant. Only 45/73 (61.6%) Xpert-identified RIF-resistant isolates had concomitant MTBDRplus-detected INH resistance. Xpert had a sensitivity of 100.0% (95% CI, 92.1–100.0) for detecting RIF resistance but a positive-predictive value of only 61.6% (95% CI, 49.5–72.8) for MDR-TB. The most frequent mutations associated with RIF and INH resistance were S531L and S315T1, respectively. Conclusions In this high-risk MDR-TB study population, Xpert had low positive-predictive value for the presence of MDR-TB. Comprehensive resistance testing for both INH and RIF should be performed in this setting.

scholarly journals Implementing a Short Regimen for Multidrug-Resistant Tuberculosis in Kinshasa, Democratic Republic of Congo: A Cohort Study 2014-2017

2020 ◽  
Vol 08 (03) ◽  
pp. 111-126
Author(s):  
Innocent Murhula Kashongwe ◽  
Leopoldine Mbulula ◽  
Fina Mawete ◽  
Nicole Anshambi ◽  
Nadine Maingowa ◽  
...  
Keyword(s):  
Cohort Study ◽  
Democratic Republic ◽  
Democratic Republic Of Congo ◽  
Multidrug Resistant ◽  
Republic Of Congo ◽  
Resistant Tuberculosis ◽  
Multidrug Resistant Tuberculosis

scholarly journals Multidrug-Resistant Tuberculosis in the Democratic Republic of Congo: Analysis of Continuous Surveillance Data from 2007 to 2016

2019 ◽  
Vol 07 (01) ◽  
pp. 25-44 ◽  
Author(s):  
Serge Bisuta-Fueza ◽  
Jean Marie Kayembe-Ntumba ◽  
Marie-Jose Kabedi-Bajani ◽  
Pascale Mulomba Sabwe ◽  
Hippolyte Situakibanza-Nani Tuma ◽  
...  
Keyword(s):  
Democratic Republic ◽  
Democratic Republic Of Congo ◽  
Multidrug Resistant ◽  
Surveillance Data ◽  
Republic Of Congo ◽  
Resistant Tuberculosis ◽  
Multidrug Resistant Tuberculosis

scholarly journals Factors Associated with Mortality among Multidrug Resistant Tuberculosis MDR/RR-TB Patients in Democratic Republic of Congo

2017 ◽  
Vol 05 (04) ◽  
pp. 276-291 ◽  
Author(s):  
Murhula Innocent Kashongwe ◽  
Leopoldine Mbulula ◽  
Pierre Umba ◽  
Francois Bompeka Lepira ◽  
Michel Kaswa ◽  
...  
Keyword(s):  
Democratic Republic ◽  
Democratic Republic Of Congo ◽  
Multidrug Resistant ◽  
Republic Of Congo ◽  
Factors Associated ◽  
Resistant Tuberculosis ◽  
Multidrug Resistant Tuberculosis
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