scholarly journals Asymptomatic Severe Acute Respiratory Syndrome–associated Coronavirus Infection

2003 ◽  
Vol 9 (11) ◽  
pp. 1491-1492 ◽  
Author(s):  
Harold K.K. Lee ◽  
Eugene Y.K. Tso ◽  
T. N. Chau ◽  
Owen T.Y. Tsang ◽  
W. Choi ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Coronavirus Infection

scholarly journals An Update on Animal Models for Severe Acute Respiratory Syndrome Coronavirus 2 Infection and Countermeasure Development

2021 ◽  
Vol 12 ◽  
Author(s):  
Liang Zhang ◽  
Shuaiyin Chen ◽  
Weiguo Zhang ◽  
Haiyan Yang ◽  
Yuefei Jin ◽  
...  
Keyword(s):  
Animal Models ◽  
Severe Acute Respiratory Syndrome ◽  
Research Progress ◽  
Laboratory Mice ◽  
Disease Manifestation ◽  
Highly Pathogenic ◽  
The World ◽  
Coronavirus Infection ◽  
Different Levels ◽  
Critical Aspects

Coronavirus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a pandemic since March 2020 and led to significant challenges to over 200 countries and regions all over the world. The establishment of highly pathogenic coronavirus animal model is beneficial for the study of vaccines and pathogenic mechanism of the virus. Laboratory mice, Syrian hamsters, Non-human primates and Ferrets have been used to establish animal models of emerging coronavirus infection. Different animal models can reproduce clinical infection symptoms at different levels. Appropriate animal models are of great significance for the pathogenesis of COVID-19 and the research progress related to vaccines. This review aims to introduce the current progress about experimental animal models for SARS-CoV-2, and collectively generalize critical aspects of disease manifestation in humans and increase their usefulness in research into COVID-19 pathogenesis and developing new preventions and treatments.

scholarly journals A case of severe acute respiratory syndrome coronavirus 2 with acute thrombotic cerebral infarction and generalized thrombosis

2021 ◽  
pp. 405-408
Author(s):  
Sylvia Nikolaeva Genova ◽  
Nikolaeva Genova ◽  
Mina Miroslavova Pencheva ◽  
Alexander Georgiev Ivanov
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Cerebral Infarction ◽  
Viral Pneumonia ◽  
Autopsy Case ◽  
Full Spectrum ◽  
Histological Changes ◽  
Large Size ◽  
Thrombotic Complications ◽  
Coronavirus Infection ◽  
The Brain

The full spectrum of coronavirus disease 2019 (COVID-19) has not been fully described yet. COVID-19 is associated with a high risk of thrombotic complications such as venous thromboembolism and cerebrovascular disease. Here, we report an autopsy case of a 55-year-old woman diagnosed with severe viral pneumonia complicated by acute cerebral infarction and venous and arterial thrombosis in different organs. The patient died due to severe acute respiratory syndrome coronavirus 2. Macroscopically and histologically, in addition to viral pneumonia and diffuse hemorrhages, fibrin clots were found in arteries and venous vessels of medium and large size in the brain, lungs, and pancreas. Propagation of cerebrovascular thrombosis has led to extensive cerebral infarction. The dating of this infarction, according to the macroscopical findings and the histological changes, was between 24 and 48 h before death. This case confirms the hypothesis on the risk of generalized arterial and venous thromboses in coronavirus infection.

scholarly journals A self-care with Ou MC decrescendo phenomenon may possibly prevent mild COVID-19 disease developing into severe or critical stage

2020 ◽  
Vol 6 (4) ◽  
Author(s):  
Ming Cheh Ou ◽  
Dennis Ou ◽  
Chung Chu Pang
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Inflammatory Reaction ◽  
Physiological Response ◽  
Joint Pain ◽  
Self Care ◽  
Critical Stage ◽  
Contralateral Hand ◽  
Infection Disease ◽  
Coronavirus Infection

Ou MC decrescendo phenomenon treatment (OuDPt) is a self-administered practice in which the interactions of the anatomical axes result in a physiological response and produce a zone under the contralateral hand with decreased pain or inflammation. OuDPt has shown an effect to alleviate cough, rhinorrhea, headache, acute edematous swellings, dysmenorrhea, endometriosis and joint pain that are related to inflammatory reaction. Most symptoms with coronavirus infection disease 2019 (COVID-19) as fever, cough, myalgia or diarrhea are also associated with inflammation. If the inflammation by severe acute respiratory syndrome coronavirus 2 is suppressed, mild COVID-19 disease may not develop into severe or critical stage. Further investigations are warranted.

Severe Acute Respiratory Syndrome-Associated Coronavirus Infection in Toronto Children: A Second Look

PEDIATRICS ◽  
2009 ◽  
Vol 123 (1) ◽  
pp. 97-101 ◽  
Author(s):  
A. Bitnun ◽  
S. Read ◽  
R. Tellier ◽  
M. Petric ◽  
S. E. Richardson
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Second Look ◽  
Coronavirus Infection

Inhibition of Severe Acute Respiratory Syndrome-Associated Coronavirus Infection by Equine Neutralizing Antibody in Golden Syrian Hamsters

2007 ◽  
Vol 20 (1) ◽  
pp. 197-205 ◽  
Author(s):  
Guangyu Zhao ◽  
Bing Ni ◽  
Haiyan Jiang ◽  
Deyan Luo ◽  
Marek Pacal ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Neutralizing Antibody ◽  
Syrian Hamsters ◽  
Coronavirus Infection

scholarly journals Protease-mediated enhancement of severe acute respiratory syndrome coronavirus infection

2005 ◽  
Vol 102 (35) ◽  
pp. 12543-12547 ◽  
Author(s):  
S. Matsuyama ◽  
M. Ujike ◽  
S. Morikawa ◽  
M. Tashiro ◽  
F. Taguchi
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Coronavirus Infection

scholarly journals Antibody response and viraemia during the course of severe acute respiratory syndrome (SARS)-associated coronavirus infection

2004 ◽  
Vol 53 (5) ◽  
pp. 435-438 ◽  
Author(s):  
Weijun Chen ◽  
Zuyuan Xu ◽  
Jingsong Mu ◽  
Ling Yang ◽  
Haixue Gan ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Antibody Response ◽  
Time Course ◽  
Recovery Phase ◽  
Antibody Responses ◽  
Igg Antibodies ◽  
Rt Pcr ◽  
Blood Samples ◽  
Convalescent Phase ◽  
Coronavirus Infection

To understand the time-course of viraemia and antibody responses to severe acute respiratory syndrome-associated coronavirus (SARS-CoV), RT-PCR and ELISA were used to assay 376 blood samples from 135 SARS patients at various stages of the illness, including samples from patients who were in their early convalescent phase. The results showed that IgM antibodies decreased and became undetectable 11 weeks into the recovery phase. IgG antibodies, however, remained detectable for a period beyond 11 weeks and were found in 100 % of patients in the early convalescent phase. SARS-CoV viraemia mainly appeared 1 week after the onset of illness and then decreased over a period of 1 month, becoming undetectable in the blood samples of the convalescent patients. At the peak of viraemia, viral RNA was detectable in 75 % of blood samples from patients who were clinically diagnosed with SARS 1 or 2 weeks before the test.

scholarly journals Evaluation of Inapparent Nosocomial Severe Acute Respiratory Syndrome Coronavirus Infection in Vietnam by Use of Highly Specific Recombinant Truncated Nucleocapsid Protein-Based Enzyme-Linked Immunosorbent Assay

2005 ◽  
Vol 12 (7) ◽  
pp. 848-854 ◽  
Author(s):  
Fuxun Yu ◽  
Mai Quynh Le ◽  
Shingo Inoue ◽  
Hong Thi Cam Thai ◽  
Futoshi Hasebe ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Large Scale ◽  
Screening Method ◽  
Epidemiological Studies ◽  
Enzyme Linked Immunosorbent Assay ◽  
Serum Samples ◽  
Nucleocapsid Proteins ◽  
N Protein ◽  
Care Workers ◽  
Coronavirus Infection

ABSTRACT Severe acute respiratory syndrome (SARS) is a recently emerged human disease associated with pneumonia. Inapparent infection with SARS coronavirus (CoV) is not well characterized. To develop a safe, simple, and reliable screening method for SARS diagnosis and epidemiological study, two recombinant SARS-CoV nucleocapsid proteins (N′ protein and NΔ121 protein) were expressed in Escherichia coli, purified by affinity chromatography, and used as antigens for indirect, immunoglobulin G enzyme-linked immunosorbent assays (ELISA). Serum samples collected from healthy volunteers and SARS patients in Vietnam were used to evaluate the newly developed methods. The N′ protein-based ELISA showed a highly nonspecific reaction. The NΔ121 protein-based ELISA, with a nonspecific reaction drastically reduced compared to that of the nearly-whole-length N′ protein-based ELISA, resulted in higher rates of positive reactions, higher titers, and earlier detection than the SARS-CoV-infected cell lysate-based ELISA. These results indicate that our newly developed SARS-CoV NΔ121 protein-based ELISA is not only safe but also a more specific and more sensitive method to diagnose SARS-CoV infection and hence a useful tool for large-scale epidemiological studies. To identify inapparent SARS-CoV infections, serum samples collected from health care workers (HCWs) in Vietnam were screened by the NΔ121 protein-based ELISA, and positive samples were confirmed by a virus neutralization test. Four out of 149 HCWs were identified to have inapparent SARS-CoV infection in Vietnam, indicating that subclinical SARS-CoV infection in Vietnam is rare but does exist.

scholarly journals Severe Acute Respiratory Syndrome–associated Coronavirus Infection

2003 ◽  
Vol 9 (11) ◽  
pp. 1453-1454 ◽  
Author(s):  
Paul K.S. Chan ◽  
Margaret Ip ◽  
KC Ng ◽  
Rickjason C. W. Chan ◽  
Alan Wu ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Coronavirus Infection
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