scholarly journals Blood Lactate Functions as a Signal for Enhancing Fatty Acid Metabolism during Exercise via TGF-^|^beta; in the Brain

2012 ◽  
Vol 58 (2) ◽  
pp. 88-95 ◽  
Author(s):  
Hiroyuki YAMADA ◽  
Yoko IWAKI ◽  
Ryo KITAOKA ◽  
Mina FUJITANI ◽  
Tetsuro SHIBAKUSA ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Blood Lactate ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Tgf Beta ◽  
The Brain

scholarly journals Association between fatty acid metabolism in the brain and Alzheimer disease neuropathology and cognitive performance: A nontargeted metabolomic study

PLoS Medicine ◽  
2017 ◽  
Vol 14 (3) ◽  
pp. e1002266 ◽  
Author(s):  
Stuart G. Snowden ◽  
Amera A. Ebshiana ◽  
Abdul Hye ◽  
Yang An ◽  
Olga Pletnikova ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Alzheimer Disease ◽  
Cognitive Performance ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
The Brain ◽  
Metabolomic Study

scholarly journals Mitochondrial Dysfunction in Astrocytes: A Role in Parkinson’s Disease?

2021 ◽  
Vol 8 ◽  
Author(s):  
Collin M. Bantle ◽  
Warren D. Hirst ◽  
Andreas Weihofen ◽  
Evgeny Shlevkov
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Fatty Acid ◽  
Mitochondrial Dysfunction ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Glutamate Metabolism ◽  
Cell Type ◽  
Therapeutic Development ◽  
The Brain

Mitochondrial dysfunction is a hallmark of Parkinson’s disease (PD). Astrocytes are the most abundant glial cell type in the brain and are thought to play a pivotal role in the progression of PD. Emerging evidence suggests that many astrocytic functions, including glutamate metabolism, Ca2+ signaling, fatty acid metabolism, antioxidant production, and inflammation are dependent on healthy mitochondria. Here, we review how mitochondrial dysfunction impacts astrocytes, highliting translational gaps and opening new questions for therapeutic development.

Effect of Enoxacin, Felbinac, and Sparfloxacin on Fatty Acid Metabolism and Glucose Concentrations in Rat Tissues

2011 ◽  
Vol 30 (3) ◽  
pp. 367-376 ◽  
Author(s):  
Fumiyo Kasuya ◽  
Yasushi Miwa ◽  
Maya Kazumi ◽  
Hiroyuki Inoue ◽  
Hiroyuki Ohta
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Rat Tissues ◽  
Antimicrobial Drugs ◽  
Glucose Levels ◽  
Chain Acyl ◽  
The Brain ◽  
Long Chain ◽  
Increased Susceptibility

Multiple changes in metabolic levels could be useful for understanding physiological toxicity. To explore further risk factors for the convulsions induced by the interaction of nonsteroidal anti-inflammatory and new quinolone antimicrobial drugs, the effect of sparfloxacin, enoxacin, and felbinac on fatty acid metabolism and glucose concentrations in the liver, brain, and blood of rats was investigated. The levels of long-chain acyl-CoAs (C18:1 and C20:4) in the liver and brain were decreased at the onset of convulsions induced by the coadministration of enoxacin with felbinac. Then, glucose concentrations in the liver and blood were decreased, whereas they were increased in a dose-dependant manner in the brain. However, the formation of acyl-CoAs and glucose levels in the liver, brain, and blood was not significantly influenced by enoxacin, felbinac, and sparfloxacin alone, respectively. The disturbance of both fatty acid metabolism and glucose levels might be associated with the increased susceptibility to convulsions, which may contribute to further understanding of the toxic effects associated with these drugs.

scholarly journals ABCA7 Regulates Brain Fatty Acid Metabolism During LPS-Induced Acute Inflammation

2021 ◽  
Vol 15 ◽  
Author(s):  
Tomonori Aikawa ◽  
Yingxue Ren ◽  
Marie-Louise Holm ◽  
Yan W. Asmann ◽  
Amer Alam ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Premature Termination Codon ◽  
Susceptibility Loci ◽  
Loss Of Function ◽  
Transporter Family ◽  
Increased Risk ◽  
Metabolite Content ◽  
The Brain

The ATP binding cassette subfamily A member 7 (ABCA7) gene is one of the significant susceptibility loci for Alzheimer’s disease (AD). Furthermore, ABCA7 loss of function variants resulting from premature termination codon in the gene are associated with increased risk for AD. ABCA7 belongs to the ABC transporter family, which mediates the transport of diverse metabolites across the cell membrane. ABCA7 is also involved in modulating immune responses. Because the immune system and lipid metabolism causatively engage in the pathogenesis of AD, we investigated how ABCA7 haplodeficiency modulates the metabolic profile in mouse brains during acute immune response using a metabolomics approach through LC/Q-TOF-MS. Peripheral lipopolysaccharide (LPS) stimulation substantially influenced the metabolite content in the cortex, however, the effect on metabolic profiles in Abca7 heterozygous knockout mice (Abca7±) was modest compared to that in the control wild-type mice. Weighted gene co-expression network analysis (WGCNA) of the metabolomics dataset identified two modules influenced by LPS administration and ABCA7 haplodeficiency, in which glycerophospholipid metabolism, linoleic acid metabolism, and α-linolenic acid metabolism were identified as major pathways. Consistent with these findings, we also found that LPS stimulation increased the brain levels of eicosapentaenoic acid, oleic acid, and palmitic acid in Abca7± mice, but not control mice. Together, our results indicate that ABCA7 is involved in the crosstalk between fatty acid metabolism and inflammation in the brain, and disturbances in these pathways may contribute to the risk for AD.

The Influence of Lactate and Dipyridamole on Myocardial Fatty Acid Metabolism in Man, Traced with 123l-17-lodo-heptadecanoic Acid

1990 ◽  
Vol 29 (01) ◽  
pp. 28-34 ◽  
Author(s):  
F. C. Visser ◽  
M. J. van Eenige ◽  
G. Westera ◽  
J. P. Roos ◽  
C. M. B. Duwel
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Time Activity ◽  
Time Value ◽  
Myocardial Fatty Acid Metabolism ◽  
Coronary Vasodilatation ◽  
Activity Curve ◽  
Normal Human ◽  
Plasma Lactate Level

Changes in myocardial metabolism can be detected externally by registration of time-activity curves after administration of radioiodinated fatty acids. In this scintigraphic study the influence of lactate on fatty acid metabolism was investigated in the normal human myocardium, traced with 123l-17-iodoheptadecanoic acid (123l-17-HDA). In patients (paired, n = 7) lactate loading decreased the uptake of 123l-17-HDA significantly from 27 (control: 22-36) to 20 counts/min/pixel (16-31; p <0.05 Wilcoxon). The half-time value increased to more than 60 rriin (n = 5), oxidation decreased from 61 to 42%. Coronary vasodilatation, a well-known side effect of lactate loading, was studied separately in a dipyridamole study (paired, n = 6). Coronary vasodilatation did not influence the parameters of the time-activity curve. These results suggest that changes in plasma lactate level as occurring, among other effects, during exercise will influence the parameters of dynamic 123l-17-HDA scintigraphy of the heart.

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