scholarly journals A Study of the Association between Serum Bone-Specific Alkaline Phosphatase and Serum Phosphorus Concentration or Dietary Phosphorus Intake

2012 ◽  
Vol 58 (6) ◽  
pp. 442-445 ◽  
Author(s):  
Mayu HARAIKAWA ◽  
Rieko TANABE ◽  
Natsuko SOGABE ◽  
Aoi SUGIMOTO ◽  
Yuka KAWAMURA ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Serum Phosphorus ◽  
Phosphorus Concentration ◽  
Specific Alkaline Phosphatase ◽  
Bone Specific Alkaline Phosphatase ◽  
Dietary Phosphorus ◽  
Dietary Phosphorus Intake ◽  
Phosphorus Intake

Circulating phosphorus level and risk of prostate cancer: a Mendelian randomization study

2021 ◽  
Author(s):  
Linshuoshuo Lv ◽  
Ding Ye ◽  
Jie Chen ◽  
Yu Qian ◽  
Alan Nuo Fu ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Observational Studies ◽  
Mendelian Randomization ◽  
Meta Analysis ◽  
Serum Phosphorus ◽  
Phosphorus Level ◽  
Dietary Phosphorus ◽  
Dietary Phosphorus Intake ◽  
Phosphorus Intake ◽  
Phosphorus Levels

Abstract Background Recent observational studies have suggested that circulating phosphorus levels are positively associated with risk of prostate cancer. However, little is known about the causal direction of the association. Objective To explore the potential causal relationship between circulating phosphorus and risk of prostate cancer, we conducted a Mendelian randomization (MR) study. Design Summary statistics of prostate cancer were obtained from a meta-analysis of genome-wide association studies (GWAS) consisting of 79,148 cases and 61,106 controls. Single nucleotide polymorphisms (SNP) associated with serum phosphorus level were selected from a GWAS of 291,408 individuals from the UK Biobank. MR analysis was performed using the inverse-variance weighted (IVW) method, supplemented with simple-median, weighted-median, maximum likelihood-based, MR-Egger regression and MR-PRESSO test. We also performed a meta-analysis of observational studies to assess the associations of dietary phosphorus intake and serum phosphorus level with risk of prostate cancer. Results In the MR analysis, a total of 125 independent SNPs associated with serum phosphorus levels were used as instrumental variables. Genetically predicted serum phosphorus levels were associated with a 19% increased risk of prostate cancer (95% confidence interval (CI): 9%, 31%) per one SD increment of serum phosphorus by IVW (P = 1.82 × 10–4). Sensitivity analyses using alternative MR methods produced similar positive associations, and no evidence of pleiotropy was detected by MR-Egger regression (P = 0.422). For meta-analysis, eight studies for dietary phosphorus intake and four for serum phosphorus levels were included involving a total of 669,080 participants. Consistently, high dietary phosphorus intake and serum phosphorus levels were associated with an 8% (95% CI: 4%, 12%) and 7% (95% CI: 1%, 14%) increase in prostate cancer risk, respectively. Conclusions Our study suggested a potential causal relationship between circulating phosphorus and risk of prostate cancer. Further studies are warranted to elucidate the underlying mechanism of phosphorus in the development of prostate cancer.

MO593CONTROLLING DIETARY PHOSPHORUS IN CHRONIC KIDNEY DISEASE STAGES 1 AND 2  DECREASES PROTEINURIA AND PREVENTS DECLINE IN RENAL FUNCTION

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Anita Saxena ◽  
Amit Gupta ◽  
Trisha Sachan ◽  
Vishwas Kapoor ◽  
Anup Kumar ◽  
...  
Keyword(s):  
Dietary Protein ◽  
Serum Phosphorus ◽  
Dietary Phosphorus ◽  
Significant Difference ◽  
Low Phosphorus ◽  
Group 2 ◽  
Dietary Phosphorus Intake ◽  
Fgf 23 ◽  
Phosphorus Intake ◽  
Group 1

Abstract Background and Aims High phosphorus intake is known to cause renal and vascular calcification and renal tubular injury and albuminuria. Dietary phosphorus restriction is therapeutic for controlling disordered phosphorus homeostasis and for improving cardiovascular outcomes in CKD. However, early restriction of dietary phosphorus is not advocated Aim: To evaluate if early control of dietary phosphorus ameliorates proteinuria, prevents decline in glomerular filtration rate and prevents increase in FGF-23 Method One year longitudinal study on 79 CKD patients in stages 1 and 2. eGFR, serum creatinine , phosphorus, calcium, FGF-23, soluble α-Klotho iPTH FGF 23, blood pressure, were evaluated and compared with 35 controls. 3 days dietary intake was taken using standard methodology on first visit, 6 and 12 months. CKD patients were grouped based on dietary phosphorus intake: Group 1 (n 42): normal phosphorous intake (<1000mg/day) and Group 2 (n=37; 17 in CKD 1; 20 CKD 2): high phosphorous intake (>1000mg/d). Patients in Group 2 were educated on high and low phosphorus foods and counselled to avoid fresh and frozen and processed meat, eggs, nuts and seeds, chocolates, packaged food, phosphorus-containing food additives and counselled to adopt a plant-based diet, for low phosphorus availability/absorption diet with directed diet plan. Lentils and pulses, milk and milk products (hard cheese, ice-creams, custards, cottage cheese, pudding, yoghurt), bran and whole wheat cereals were restricted up to 1-2 servings a day Data were analysed using SPSS. Results At baseline there was no significant difference in the GFR (group1 85.00±18.64 ml/min vs group 2 82.53±16.30ml/min), serum creatinine between groups. In group2 ; GFR, sKlotho, serum phosphorus and FGF-23 correlated significantly with dietary phosphorus intake. In group 2, FGF-23, Serum phosphorus, dietary protein and phosphorus intake were significantly higher and sKlotho was significantly lower than group 1. There was significant difference in serum phosphorus (p 0.000), iPTH, (p 0.004), FGF23 (p0.000), Klotho (p0.000), urinary protein (p0.000), dietary protein (Group 1 37.57±3.40; Group 248.79±5.86 p 0.000) and phosphorus (Group 1868.96±69.99 mg/d and Group 2 1312.26±137.57 mg/d p 0.000) intake and dietary phosphorous to protein ratio (p 0.000) between groups 1 and 2.. After dietary intervention in group 2 GFR increased from 80.93±15.34 to 84.11±15.38 in six months and to 87.43±18.27 ml/min at 12 months p 0.012, and urinary protein declined to 22.01±3.39 mg/mL. FGF 23 declined from 60.67±6.26 to 58.00±7.07 to 53.29±9.48 pg/mL at 12 months. Urinary phosphorus excretion increased from 574.37±214.22 to 624.64±137.67 at 12 months. Dietary phosphorus protein to ratio reduced from 27.16±4.35 to24.75±4.34 p 0.000 at 12 months Conclusion CKD patients should be cautioned and counselled on their first visit on the impact of dietary phosphorus intake on the progression of CKD and development of CVD.

scholarly journals Opposite correlation of 25-hydroxy-vitamin D- and 1,25-dihydroxy-vitamin D-metabolites with gestational age, bone- and lipid-biomarkers in pregnant women

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Oleg Tsuprykov ◽  
Saban Elitok ◽  
Claudia Buse ◽  
Chang Chu ◽  
Bernhard Karl Krämer ◽  
...  
Keyword(s):  
Vitamin D ◽  
Alkaline Phosphatase ◽  
Pregnant Women ◽  
Clinical Chemistry ◽  
Water Soluble ◽  
Target Cells ◽  
Vitamin D Metabolites ◽  
Specific Alkaline Phosphatase ◽  
Bone Specific Alkaline Phosphatase ◽  
Group B

Abstract25-Hydroxyvitamin D (25OHD) and 1,25-dihydroxyvitamin D (1,25(OH)2D) need to be bound to carrier proteins to be transported to their target cells. The majority of either 25OHD or 1,25(OH)2D is bound to vitamin D-binding protein (DBP), a smaller fraction is bound to albumin and only very small amounts of 25OHD or 1,25(OH)2D are free. Albumin-bound 25OHD or 1,25(OH)2D is relatively easily available after dissociation from albumin. Thus, the sum of free and albumin-bound forms is called bioavailable 25OHD and bioavailable 1,25(OH)2D. Total 25OHD and 1,25(OH)2D are defined as the sum of free, albumin-bound and DBP-bound 25OHD and 1,25(OH)2D, respectively. This cross-sectional study in 427 pregnant women compared the correlation of the six vitamin D compounds with biomarkers of bone health, lipid metabolism, kidney function, endocrine parameters, and group B water-soluble vitamins. Among the 25OHD metabolites analysed, total 1,25(OH)2D showed clearly the best correlation with calcium, bone-specific alkaline phosphatase, adiponectin, LDL, HDL, urea, thyroxine, and group B water-soluble vitamins. When comparing the three 25OHD metabolites, both free 25OHD and bioavailable 25OHD showed overall good correlations with calcium, bone-specific alkaline phosphatase, adiponectin, LDL, HDL, urea, thyroxine, triiodothyronine, and group B water-soluble vitamins, The correlations of 1,25(OH)2D and 25OHD metabolites went always in opposite directions. Only PTH correlates always inversely with all six vitamin D compounds. In conclusion, free 25(OH)D and bioavailable 25(OH)D are more precise determinants of the vitamin D status than total 25(OH)D in normal pregnancy, whereas total 1,25(OH)2D is superior to free and bioavailable 1,25(OH)2D. Except for PTH, correlations of 25(OH)D and 1,25(OH)2D metabolites with typical clinical chemistry readouts go in opposite directions.

scholarly journals Acute Response of Sclerostin to Whole-body Vibration with Blood Flow Restriction

2021 ◽  
Author(s):  
Kyle S Gapper ◽  
Sally Stevens ◽  
Rona Antoni ◽  
Julie Hunt ◽  
Sarah J Allison
Keyword(s):  
Alkaline Phosphatase ◽  
Blood Flow ◽  
Whole Body Vibration ◽  
Blood Flow Restriction ◽  
Whole Body ◽  
Specific Alkaline Phosphatase ◽  
Body Vibration ◽  
Bone Specific Alkaline Phosphatase ◽  
Flow Restriction ◽  
Acute Response

AbstractBlood flow restriction may augment the skeletal response to whole-body vibration. This study used a randomised, crossover design to investigate the acute response of serum sclerostin and bone turnover biomarkers to whole-body vibration with blood flow restriction. Ten healthy males (mean±standard deviation; age: 27±8 years) completed two experimental conditions separated by 7 days: (i) whole-body vibration (10 1-minute bouts of whole-body vibration with 30 s recovery) or (ii) whole-body vibration with lower-body blood flow restriction (10 cycles of 110 mmHg inflation with 30 s deflation during recovery). Fasting blood samples were obtained immediately before and immediately after exercise, then 1 hour, and 24 hours after exercise. Serum samples were analysed for sclerostin, cross-linked C-terminal telopeptide of type I collagen, and bone-specific alkaline phosphatase. There was a significant time × condition interaction for bone-specific alkaline phosphatase (p=0.003); bone-specific alkaline phosphatase values at 24 hours post-exercise were significantly higher following whole-body vibration compared to combined whole-body vibration and blood flow restriction (p=0.028). No significant time × condition interaction occurred for any other outcome measure (p>0.05). These findings suggest that a single session of whole-body vibration combined with blood flow restriction does not significantly affect serum sclerostin or bone turnover biomarkers.

scholarly journals High dietary phosphorus intake is associated with all-cause mortality: results from NHANES III

2013 ◽  
Vol 99 (2) ◽  
pp. 320-327 ◽  
Author(s):  
Alex R Chang ◽  
Mariana Lazo ◽  
Lawrence J Appel ◽  
Orlando M Gutiérrez ◽  
Morgan E Grams
Keyword(s):  
Nhanes Iii ◽  
Dietary Phosphorus ◽  
All Cause Mortality ◽  
Dietary Phosphorus Intake ◽  
Phosphorus Intake

High dietary phosphorus intake is associated with an increased risk of type 2 diabetes in the large prospective E3N cohort study

2018 ◽  
Vol 37 (5) ◽  
pp. 1625-1630 ◽  
Author(s):  
Francesca Romana Mancini ◽  
Aurélie Affret ◽  
Courtney Dow ◽  
Beverley Balkau ◽  
Françoise Clavel-Chapelon ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cohort Study ◽  
Dietary Phosphorus ◽  
Increased Risk ◽  
Dietary Phosphorus Intake ◽  
Phosphorus Intake

scholarly journals Effect of dietary phosphorus intake and age on intestinal phosphorus absorption efficiency and phosphorus balance in male rats

PLoS ONE ◽  
2018 ◽  
Vol 13 (11) ◽  
pp. e0207601 ◽  
Author(s):  
Colby J. Vorland ◽  
Pamela J. Lachcik ◽  
Loretta O. Aromeh ◽  
Sharon M. Moe ◽  
Neal X. Chen ◽  
...  
Keyword(s):  
Absorption Efficiency ◽  
Male Rats ◽  
Phosphorus Balance ◽  
Phosphorus Absorption ◽  
Dietary Phosphorus ◽  
Dietary Phosphorus Intake ◽  
Phosphorus Intake
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