scholarly journals Effects of Dietary Docosahexaenoic Acid Connecting Phospholipids on the Learning Ability and Fatty Acid Composition of the Brain

2009 ◽  
Vol 55 (4) ◽  
pp. 374-380 ◽  
Author(s):  
Seiichi HIRATSUKA ◽  
Kyoko KOIZUMI ◽  
Tomoko OOBA ◽  
Hidehiko YOKOGOSHI
Keyword(s):  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Docosahexaenoic Acid ◽  
Acid Composition ◽  
Learning Ability ◽  
Dietary Docosahexaenoic Acid ◽  
The Brain

Effect of Dietary Docosahexaenoic Acid and Phosphatidylcholine on Maze Behavior and Fatty Acid Composition of Plasma and Brain Lipids in Mice

2000 ◽  
Vol 70 (5) ◽  
pp. 251-259 ◽  
Author(s):  
Sun-Young Lim ◽  
Hiramitsu Suzuki
Keyword(s):  
Fatty Acids ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Acid Composition ◽  
Palm Oil ◽  
Maze Learning ◽  
Learning Ability ◽  
Control Group ◽  
Dietary Docosahexaenoic Acid ◽  
Group 5

We investigated the effects of dietary docosahexaenoic acid (DHA, 22:6 n-3) and phosphatidylcholine (PC) on maze behavior and brain fatty acids in mice. Male Crj:CD-1 mice (3 wk old) were fed a diet containing 2% DHA and 3% palm oil (DHA group); 5% PC (PC group); 1% DHA, 2.5% PC and 1.5% palm oil (DHA+PC group); 5% palm oil (Palm oil control group) or MF laboratory chow (MF control group) for 7 mo. After this time maze-learning ability was assessed. The time required to reach the maze exit and the number of times that a mouse strayed into blind alleys in the maze were measured three times every four days. After the last learning test, all mice were sacrificed and plasma and brain were analyzed for fatty acid composition. The DHA and PC groups required less time to reach the maze exit and strayed less into blind alleys than the control group in the third trial. The difference between the DHA or PC groups and control mice was statistically significant (p < 0.05). In the total lipids of plasma and brain of mice fed DHA, there was a significant increase in DHA levels and a concomitant decrease in arachidonic acid (AA, 20:4 n-6). Similar changes in fatty acid composition were observed in brain phosphatidylcholine and phosphatidylethanolamine for this group of mice. However, this pattern of changes in brain fatty acids was not evident in the PC group. Our data suggest that maze-learning ability in mice is enhanced by intakes of DHA and PC. However, the mechanisms by which the DHA and PC diets improved learning ability appear to be different. A synergistic effect of DHA and PC on learning ability is not apparent in the DHA+PC group.

Docosahexaenoic acid supplementation in pregnancy alters placental fatty acid composition

Placenta ◽  
2014 ◽  
Vol 35 (9) ◽  
pp. A70 ◽  
Author(s):  
Theresa L. Powell ◽  
Christiane Meireles ◽  
Vanessa I. Ramirez ◽  
Evelyn Miller ◽  
Kevin W. Hakala ◽  
...  
Keyword(s):  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Docosahexaenoic Acid ◽  
Acid Composition ◽  
Acid Supplementation ◽  
In Pregnancy
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