scholarly journals Regulation of Plasma and Liver Total Cholesterol Levels by Dietary Oleic Acid in Rats Fed a High-Cholesterol Diet.

1999 ◽  
Vol 45 (1) ◽  
pp. 63-77 ◽  
Author(s):  
Hisanao TAKEUCHI ◽  
Tyojin KATO ◽  
Hiroshi IKEGAMI ◽  
Hiroshi IMAI ◽  
Hiroyuki TAKEUCHI
Keyword(s):  
Oleic Acid ◽  
Total Cholesterol ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Cholesterol Levels

scholarly journals PEMBERIAN EKSTRAK ETANOL BUAH BUNCIS (Phaseolus vulgaris L.) UNTUK MENURUNKAN KOLESTEROL TOTAL, Low Density Lipoprotein (LDL) DAN MENINGKATKAN High Density Lipoprotein (HDL) PADA TIKUS WISTAR DIET TINGGI LEMAK

Jurnal Kimia ◽  
2016 ◽  
Author(s):  
Sri Wahjuni ◽  
Ni Luh Rustini ◽  
Putu Yuliantari
Keyword(s):  
Total Cholesterol ◽  
Cholesterol Level ◽  
Density Lipoprotein ◽  
Ethanol Extract ◽  
Hdl Cholesterol ◽  
Blood Cholesterol ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Cholesterol Levels

Excessive fat consumption can increase blood cholesterol level. Phytosterol composition in the plant can decrease blood cholesterol level. One of the plants that contain phytosterol is beans. This study was to prove the effect of antihypercholesterol the ethanol extract of the beans (Phaseolus vulgaris L.) with variety of doses of 50 mg/Kg BW; 100 mg/Kg BW and 150 mg/Kg BW in male Wistar rats with high fat level condition. Subjects of this study were 24 Wistar rats divided into 6 groups randomly with posttest control group study design. First group as negative control, second group as positive control, and the third (high cholesterol diet and ethanol extract in dose of 50 mg/kg,bw), fourth ( high cholesterol diet and ethanol extractin dose of 100 mg/kg,bw), fifth ( high cholesterol diet and ethanol extract in dose of 150 mg/kg,bw),  sixth (high cholesterol diet and simvastatin drug). The data was analyzed with ANOVA Tukey test. The result of this study shows total cholesterol levels decrease 23,88%; 30,14%; 35,82%. Cholesterol LDL levels decrease 38,09%; 52,38%; 61,35%. Cholesterol HDL levels increase 21,86%; 56,56%; 63,84%. Dose variant on this study giving the best result to decrease total cholesterol levels and LDL was 150 mg/Kg BW. Furthermore, 100 mg/Kg BW dose gave the best result to increase HDL cholesterol level. Based on the results it can be suggested that beans ethanol extract is able to decrease total cholesterol level, LDL and increase HDL cholesterol levels.  

The correlation between serum total cholesterol and some trace elements in serum, liver and heart of rats fed high cholesterol diet

Nahrung/Food ◽  
1991 ◽  
Vol 35 (8) ◽  
pp. 827-834 ◽  
Author(s):  
H. S. H. Abu-El-Zahab ◽  
Wafaa E. Abdel Aal ◽  
R. Awadallah ◽  
Tahani M. Mikhail ◽  
K. Zakaria
Keyword(s):  
Trace Elements ◽  
Total Cholesterol ◽  
Serum Total Cholesterol ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol

scholarly journals Effect of garlic (Allium sativum) extract on reduction of total cholesterol and HDL cholesterol ratio in hypercholesterolemic rats

2008 ◽  
Vol 6 (2) ◽  
pp. 45-51
Author(s):  
MARIA PRISKILA ◽  
DIAN ARININGRUM ◽  
ENDANG LISTYANINGSIH SUPARYANTI
Keyword(s):  
Body Weight ◽  
Total Cholesterol ◽  
Hdl Cholesterol ◽  
Garlic Extract ◽  
Control Group ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Cholesterol Ratio ◽  
Group I

Priskila M, Ariningrum D, Suparyanti ES. 2008. Effect of garlic (Allium sativum Linn.) extract on reduction of total cholesterol and HDL cholesterol ratio in hypercholesterolemic rats (Rattus norvegicus). Biofarmasi 6: 45-51. Garlic has been widely recognized as herbal medicine for prevention and treatment of cardiovascular disease, atherosclerosis, and hyperlipidemia. The main bioactive compound, allicin, can influence cholesterol metabolism, reduce total cholesterol and increase HDL cholesterol. The purpose of this research was to find out the effect of garlic extract on the reduction of total cholesterol and HDL cholesterol ratio in hypercholesterolemic rats. This research was an experimental research with pre and post-test control group design. The research used male Wistar rats (Rattus norvegicus) with ±3 mounts old and ±200 grams of body weight. The rats were divided into two groups, group I and II; each group consisted of 15 rats. Before the treatment, all rats were induced by a high-cholesterol diet for two weeks, to get a hypercholesterolemic condition. Group I, as a control group, were induced by a high-cholesterol diet, while group II, treatment group, were also induced by a high-cholesterol diet orally by 0.432 grams garlic extract /200 grams body weight/day. The treatment occurred for 25 days. The data were taken before the treatment and after the last treatment, by taking the blood from orbital sine of rats which been fasted for 12 hours, and the level of serum cholesterol total and the level of serum HDL cholesterol were checked from both groups, then the results were analyzed with t-test. Based on the results, it could be concluded that the oral induction of 0.432 grams garlic extract /200 grams body weight/day for 25 days on rats, could not reduce total cholesterol, therefore the serum total cholesterol and HDL cholesterol ratio was not significant (p>0.05). Meanwhile, the decrease of total cholesterol in treatment group and the decrease of HDL cholesterol in both groups were significant (p<0.05).

scholarly journals Phaleria macrocarpa Boerl. (Thymelaeaceae) Leaves Increase SR-BI Expression and Reduce Cholesterol Levels in Rats Fed a High Cholesterol Diet

Molecules ◽  
2015 ◽  
Vol 20 (3) ◽  
pp. 4410-4429 ◽  
Author(s):  
Yosie Andriani ◽  
Tengku Tengku-Muhammad ◽  
Habsah Mohamad ◽  
Jasnizat Saidin ◽  
Desy Syamsumir ◽  
...  
Keyword(s):  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Cholesterol Levels ◽  
Phaleria Macrocarpa

Pharmacological activation of LXR in utero directly influences ABC transporter expression and function in mice but does not affect adult cholesterol metabolism

2008 ◽  
Vol 295 (6) ◽  
pp. E1341-E1348 ◽  
Author(s):  
E. M. E. van Straten ◽  
N. C. A. Huijkman ◽  
J. F. W. Baller ◽  
F. Kuipers ◽  
T. Plösch
Keyword(s):  
Fetal Development ◽  
Cholesterol Metabolism ◽  
In Utero ◽  
Cholesterol Homeostasis ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
High Fat ◽  
Hepatic Expression ◽  
Cholesterol Levels

Cholesterol is critical for several cellular functions and essential for normal fetal development. Therefore, its metabolism is tightly controlled during all life stages. The liver X receptors-α (LXRα; NR1H3) and -β (LXRβ; NR1H2) are nuclear receptors that are of key relevance in coordinating cholesterol and fatty acid metabolism. The aim of this study was to elucidate whether fetal cholesterol metabolism can be influenced in utero via pharmacological activation of LXR and whether this would have long-term effects on cholesterol homeostasis. Administration of the LXR agonist T0901317 to pregnant mice via their diet (0.015% wt/wt) led to induced fetal hepatic expression levels of the cholesterol transporter genes Abcg5/g8 and Abca1, higher plasma cholesterol levels, and lower hepatic cholesterol levels compared with controls. These profound changes during fetal development did not affect cholesterol metabolism in adulthood nor did they influence coping with a high-fat/high-cholesterol diet. This study shows that the LXR system is functional in fetal mice and susceptible to pharmacological activation. Despite massive changes in fetal cholesterol metabolism, regulatory mechanisms involved in cholesterol metabolism return to a “normal” state in offspring and allow coping with a high-fat/high-cholesterol diet.

scholarly journals Antihypercholesterolemic and Antioxidant Effects of Blumea balsamifera L. Leaf Extracts to Maintain Luteinizing Hormone Secretion in Rats Induced by High-Cholesterol Diets

2021 ◽  
Vol 13 (4) ◽  
pp. 396-402
Author(s):  
I Gede Widhiantara ◽  
Anak Agung Ayu Putri Permatasari ◽  
I Wayan Rosiana ◽  
Putu Angga Wiradana ◽  
Luh Putu Widiastini ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Luteinizing Hormone ◽  
Total Cholesterol ◽  
Reproductive Function ◽  
Control Group ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Male Reproductive Function ◽  
Antioxidant Effects

BACKGROUND: The discovery of herbal ingredients for antihypercholesterolemic and to improve male reproductive function is very necessary due to high-cholesterol diet factors. Blumea balsamifera leaf extract (BBLE) is known to be able to increase the number and diameter of Leydig cells in rats given high-fat feed. This study was to conducted to determine the levels of total cholesterol, body weight, plasma malondialdehyde (MDA), Superoxide Dismutase (SOD), Luteinizing Hormone (LH) in high-cholesterol-fed male rats provided with BBLE.METHODS: This research utilized a randomized post-test only control group. Ethanol was used to extract the BBLE, which was then evaporated. For 21 days, 16 Wistar rats were given a high-cholesterol diet. To determine the effect of BBLE on the high-cholesterol diet, the samples were divided into two groups (control and BBLE group) on day 22. The treatments lasted 30 days. SOD, plasma MDA, LH, and total cholesterol were measured.RESULTS: The results showed that the SOD and LH parameters were significantly higher in the treatment of BBLE compared to the control group (p<0.05). The parameters of total cholesterol levels, bodyweight, and MDA of rats given BBLE were significantly lower than those of the control group (p<0.05).CONCLUSION: Our findings highlight that BBLE has antihypercholesterolemic and antioxidant effects. The BBLE also has potential to be used as a therapy to maintain male reproductive function because it has a positive effect on the hypothalamic-pituitary axis through increasing LH secretion.KEYWORDS: Malondialdehyde, Superoxide dismutase, Luteinizing hormone, Blumea balsamifera extract, High-cholesterol diet

scholarly journals Decreasing serum homocysteine and hypocholesterolemic effects of bovine lactoferrin in male rat fed with high-cholesterol diet

2018 ◽  
Vol 10 (4) ◽  
pp. 203-208 ◽  
Author(s):  
Samira Nozari ◽  
Nazila Fathi Maroufi ◽  
Mohammad Nouri ◽  
Mirhamid Paytakhti Oskouei ◽  
Javad Shiralizade ◽  
...  
Keyword(s):  
Total Cholesterol ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Male Rats ◽  
Male Rat ◽  
High Cholesterol Diet ◽  
Bovine Lactoferrin ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Serum Homocysteine

Introduction: Lipid metabolism disorder or hyperlipidemia is known as a risk factor for cardiovascular disease, the increase in serum homocysteine and leptin are associated with atherosclerotic disease. The purpose of the present study was to examine the effects of bovine lactoferrin (bLF) on serum homocysteine (Hcy), apolipoproteinA-I (ApoA-I) and B (ApoB), leptin and lipid profile changes in high-cholesterol-diet (HCD) fed rats. Methods: The Healthy Adult Sprague-Dawley (SD) male rats were randomly assigned into three experimental groups. Each group consisted of eleven male rats including control group, HCD rats and hypercholesterolemic rats, which were treated with bLF (HCD+bLF). bLF was given by gavage (200 mg/kg/d). After 4 weeks of feeding and overnight fasting, total blood samples were collected. Results: The results showed the elevated level of Hcy, leptin, total cholesterol, low density lipoprotein cholesterol (LDL-C), ApoB and decrease in ApoA-I in non-treated HCD group compared to the control rats. Administration of bLF significantly ameliorated the Hcy and leptin levels with decrease in LDL-C and total cholesterol in rats fed with a high-cholesterol diet. bLF also tended to increase low serum concentration of ApoA-I and high density lipoprotein cholesterol (HDL-C) in HCD rats. Meanwhile, upon bLF-treated rats, there was a significant decrease in ApoB in HCD group. Conclusion: The findings indicated that bLF can improve the alteration of serum Hcy, leptin, apolipproteins and lipid changes in male rats fed with high-cholesterol diet. So, bLF can counteract with HCD elicited hyper-homocysteinemia and hyper-leptinemia, suggesting it to have the useful therapeutic potential in patients with atherosclerosis and lipid disorder.

scholarly journals Ezetimibe and Simvastatin Reduce Cholesterol Levels in Zebrafish Larvae Fed a High-Cholesterol Diet

Cholesterol ◽  
2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Ji Sun Baek ◽  
Longhou Fang ◽  
Andrew C. Li ◽  
Yury I. Miller
Keyword(s):  
Low Cost ◽  
Vascular Pathology ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Lipoprotein Oxidation ◽  
Drug Candidates ◽  
Zebrafish Larvae ◽  
Cholesterol Levels ◽  
Human Atherosclerosis

Cholesterol-fed zebrafish is an emerging animal model to study metabolic, oxidative, and inflammatory vascular processes relevant to pathogenesis of human atherosclerosis. Zebrafish fed a high-cholesterol diet (HCD) develop hypercholesterolemia and are characterized by profound lipoprotein oxidation and vascular lipid accumulation. Using optically translucent zebrafish larvae has the advantage of monitoring vascular pathology and assessing the efficacy of drug candidates in live animals. Thus, we investigated whether simvastatin and ezetimibe, the principal drugs used in management of hypercholesterolemia in humans, would also reduce cholesterol levels in HCD-fed zebrafish larvae. We found that ezetimibe was well tolerated by zebrafish and effectively reduced cholesterol levels in HCD-fed larvae. In contrast, simvastatin added to water was poorly tolerated by zebrafish larvae and, when added to food, had little effect on cholesterol levels in HCD-fed larvae. Combination of low doses of ezetimibe and simvastatin had an additive effect in reducing cholesterol levels in zebrafish. These results suggest that ezetimibe exerts in zebrafish a therapeutic effect similar to that in humans and that the hypercholesterolemic zebrafish can be used as a low-cost and informative model for testing new drug candidates and for investigating mechanisms of action for existing drugs targeting dyslipidemia.

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