scholarly journals Dietary Linoleic Acid Alters .ALPHA.-Amino-.BETA.-carboxymuconate-.EPSILON.-semialdehyde Decarboxylase (ACMSD), a Key Enzyme of Niacin Synthesis from Tryptophan, in the Process of Protein Expression in Rat Liver.

1998 ◽  
Vol 44 (1) ◽  
pp. 129-136 ◽  
Author(s):  
Yukari EGASHIRA ◽  
Atsushi TANABE ◽  
Takeo OHTA ◽  
Hiroo SANADA
Keyword(s):  
Linoleic Acid ◽  
Protein Expression ◽  
Rat Liver ◽  
Dietary Linoleic Acid ◽  
Key Enzyme

scholarly journals On the mechanism of the increase in cardiolipin biosynthesis and resynthesis in hepatocytes during rat liver regeneration

2005 ◽  
Vol 386 (1) ◽  
pp. 137-143 ◽  
Author(s):  
Jennifer WEBSTER ◽  
Jenny Y. JIANG ◽  
Biao LU ◽  
Fred Y. XU ◽  
William A. TAYLOR ◽  
...  
Keyword(s):  
Linoleic Acid ◽  
Liver Regeneration ◽  
Rat Liver ◽  
De Novo ◽  
Fold Increase ◽  
Enzymic Activity ◽  
Pool Size ◽  
De Novo Biosynthesis ◽  
Key Enzyme ◽  
Rate Limiting

CL (cardiolipin) is a major mitochondrial membrane phospholipid important for the regulation of mitochondrial function. We examined CL de novo biosynthesis and its resynthesis in isolated rat liver hepatocytes prepared 48 h subsequent to two-thirds PHx (partial hepatectomy). The pool size of CL and its de novo biosynthesis from [1,3-3H]glycerol were increased 3.3-fold (P<0.05) and 3.1-fold (P<0.05) respectively in hepatocytes prepared from PHx rats compared with sham-operated controls. The reason for the increased CL biosynthesis was a 65% increase (P<0.05) in enzymic activity in PGP-S (phosphatidylglycerolphosphate synthase), a key enzyme in de novo CL biosynthesis. The increase in PGP-S activity was due to a 3-fold increase (P<0.05) of hepatic PGP-S mRNA expression. The increase in de novo CL biosynthesis and pool size corresponded to a 2.3-fold increase (P<0.05) in the amount of [1-14C]linoleic acid incorporated into CL of hepatocytes prepared from PHx rats compared with sham-operated controls, indicating an increase in CL resynthesis. The activity of MLCL-AT (monolysocardiolipin acyltransferase), a rate-limiting enzyme of CL resynthesis, was increased by 43% (P<0.05) in hepatocytes prepared from PHx rats compared with sham-operated controls; this result would explain the increase in [1-14C]linoleic acid incorporation into CL. The increase in MLCL-AT activity was due to an increase in hepatic MLCL-AT protein expression. The results show that CL de novo biosynthesis and its resynthesis are increased during liver regeneration.

scholarly journals Distribution of conjugated linoleic acid and metabolites in different lipid fractions in the rat liver

2001 ◽  
Vol 42 (7) ◽  
pp. 1056-1061 ◽  
Author(s):  
Sebastiano Banni ◽  
Gianfranca Carta ◽  
Elisabetta Angioni ◽  
Elisabettta Murru ◽  
Paolo Scanu ◽  
...  
Keyword(s):  
Linoleic Acid ◽  
Conjugated Linoleic Acid ◽  
Rat Liver ◽  
Lipid Fractions

scholarly journals Dietary linoleic acid increases and palmitic acid decreases hepatic LDL receptor protein and mRNA abundance in young pigs

1996 ◽  
Vol 37 (11) ◽  
pp. 2310-2323
Author(s):  
V A Mustad ◽  
J L Ellsworth ◽  
A D Cooper ◽  
P M Kris-Etherton ◽  
T D Etherton
Keyword(s):  
Linoleic Acid ◽  
Palmitic Acid ◽  
Ldl Receptor ◽  
Mrna Abundance ◽  
Receptor Protein ◽  
Dietary Linoleic Acid ◽  
Young Pigs

The Effect of Dietary Linoleic Acid and Pectin on Lipoprotein and Apolipoprotein Al Concentrations in Rhesus Monkeys

1984 ◽  
Vol 28 (4) ◽  
pp. 201-206 ◽  
Author(s):  
R.J. Heine ◽  
J.A. Schouten ◽  
C.M. van Gent ◽  
L.M. Havekes ◽  
P.A.R. Koopman ◽  
...  
Keyword(s):  
Linoleic Acid ◽  
Rhesus Monkeys ◽  
Dietary Linoleic Acid
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