Sinonasal Teratocarcinosarcoma with Intracranial Extension: A Case Report with Discussion of Imaging and Histopathologic Correlates

Neurographics ◽  
2019 ◽  
Vol 9 (6) ◽  
pp. 405-408
Author(s):  
A. Rizvi ◽  
H. Mehta ◽  
S. Bobra ◽  
G. M. Kleinman ◽  
D. N. Jourdy ◽  
...  
Keyword(s):  
Poor Prognosis ◽  
Case Reports ◽  
Malignant Neoplasm ◽  
Undifferentiated Carcinoma ◽  
Chemoradiation Therapy ◽  
Intracranial Extension ◽  
Imaging Features ◽  
Lymphoma Treatment ◽  
Sinonasal Teratocarcinosarcoma ◽  
Aggressive Tumor

Sinonasal teratocarcinosarcoma is a rare, malignant neoplasm of the head and neck, and a locally aggressive tumor with a poor prognosis. Few case reports have been published. We present a case of recurrent sinonasal teratocarcinosarcoma in a 39-year-old man with extension into the intracranial compartment. Here we discuss the histopathologic characteristics and nonspecific imaging features, with key differential considerations, including squamous cell carcinoma, adenocarcinoma, sinonasal undifferentiated carcinoma, esthesioneuroblastoma, and lymphoma. Treatment is ultimately composed of surgical resection and chemoradiation therapy.

scholarly journals Sinonasal teratocarcinosarcoma: a case report

2021 ◽  
Vol 7 (11) ◽  
pp. 1828
Author(s):  
Thottukadavil S. Priya ◽  
Chakramakal Joseph Andrews ◽  
S. Suresh Kumar ◽  
S. Divya
Keyword(s):  
Adenosquamous Carcinoma ◽  
Malignant Neoplasm ◽  
Olfactory Neuroblastoma ◽  
Undifferentiated Carcinoma ◽  
Intracranial Extension ◽  
Tissue Analysis ◽  
Metastatic Lesions ◽  
Malignant Mixed Tumor ◽  
Sinonasal Teratocarcinosarcoma ◽  
Gland Type

<p class="abstract">Sinonasal teratocarcinosarcoma (TCS) is a very rare malignant neoplasm of sinonasal tract with intermixed teratomatous, carcinomatous and sarcomatous elements. While the diagnosis is largely based on tissue analysis and immunohistochemistry, the mode of management demands further study. Surgical resection with or without chemotherapy and radiation therapy is currently the most accepted treatment regimen. Locally aggressive, while also associated with metastatic lesions, SNTCS is not easily resectable owing to its location and possible intracranial extension. Due to its aggressive nature over one-third of TCS tend to recur leading to treatment failure with a mean survival time of 1.9 years. Possible differentials include squamous cell carcinoma, olfactory neuroblastoma, adenocarcinoma, malignant mixed tumor of salivary gland type, undifferentiated carcinoma, malignant craniopharyngioma, mucoepidermoid carcinoma, transitional carcinoma of Schneiderian type and adenosquamous carcinoma. In this report, we present a case of TCS in a 55 years old male patient who presented to us with complaints of hyposmia, blurring of vision, diplopia and epiphora.</p>

Prolonged survival in a patient with sinonasal teratocarcinosarcoma with cranial extension

1998 ◽  
Vol 88 (4) ◽  
pp. 753-756 ◽  
Author(s):  
Shunsuke Terasaka ◽  
Max B. Medary ◽  
Donald M. Whiting ◽  
Takanori Fukushima ◽  
Evalynne J. Espejo ◽  
...  
Keyword(s):  
Rare Case ◽  
Clinical Course ◽  
Radical Surgery ◽  
Malignant Neoplasm ◽  
Intracranial Extension ◽  
Initial Symptom ◽  
Content Type ◽  
Histological Features ◽  
Sinonasal Teratocarcinosarcoma ◽  
Common Clinical Finding

✓ Sinonasal teratocarcinosarcoma is a rare malignant neoplasm characterized by the combined histological features of carcinosarcoma and teratoma. The primary symptoms of this tumor are usually nasal obstruction and epistaxis, and a nasal cavity mass is the most common clinical finding. The authors describe an exceptionally rare case in which the patient presented with massive intracranial extension and exhibited confusion as an initial symptom. He subsequently underwent combined radical surgery and radiation therapy and has remained free of disease for 31 months. The surgical approach to the lesion, histological features, and clinical course are detailed.

Teratocarcinosarcoma of the nasal cavity and ethmoid

1998 ◽  
Vol 112 (7) ◽  
pp. 682-686 ◽  
Author(s):  
Hari Shankar Sharma ◽  
Jafri Malin Abdullah ◽  
Nor Hayati Othman ◽  
Mahayidin Muhamad
Keyword(s):  
Nasal Cavity ◽  
Clinical Presentation ◽  
Clinical Course ◽  
Malignant Neoplasm ◽  
Intracranial Extension ◽  
Local Destruction ◽  
Sinonasal Teratocarcinosarcoma ◽  
Rare Malignancy ◽  
The Right ◽  
Epithelial Element

AbstractSinonasal teratocarcinosarcoma is very unusual malignant neoplasm histologically consisting of an epithelial element and one or more mesenchymal components. This is a report of teratocarcinosarcoma, in a 74-year-old male, involving the right nasal cavity and ethmoids with intracranial extension. The tumour was totally resected via the craniofacial approach and the patient was given post-operative chemotherapy. Extensive tumour necrosis, rapid growth and local destruction are the prominent features of this tumour. The clinical presentation, pathological features and clinical course of this rare malignancy are discussed with a review of the literature.

scholarly journals Primary sinonasal undifferentiated carcinoma with intracranial extension presenting postoperatively as garcin syndrome: a rare case report and review of literature

2017 ◽  
Vol 31 (4) ◽  
pp. 564-567
Author(s):  
Prajapati Hanuman Prasad ◽  
Singh Deepak Kumar ◽  
Singh Rakesh Kumar ◽  
Ahmad Faran ◽  
Chhabra Anuj
Keyword(s):  
Poor Prognosis ◽  
Rare Case ◽  
Cranial Base ◽  
Undifferentiated Carcinoma ◽  
Intracranial Extension ◽  
Advanced Stage ◽  
Review Of Literature ◽  
Sinonasal Undifferentiated Carcinoma ◽  
Rare Case Report ◽  
Radical Therapy

Abstract Sinonasal undifferentiated carcinoma (SNUC) is an aggressive malignancy originating in the mucosa lining the walls of the nasal cavity and paranasal sinuses. It is a rare tumor that usually presents in an advanced stage, is highly invasive, and is traditionally reputed to be refractory to even the most radical therapy with an attendant poor prognosis. This is particularly true when it transgresses the cranial base.

Imaging Features of Primary Tumors of the Hand

2020 ◽  
Vol 16 ◽  
Author(s):  
Filippo Boriani ◽  
Edoardo Raposio ◽  
Costantino Errani
Keyword(s):  
Soft Tissue ◽  
Soft Tissues ◽  
Epithelioid Sarcoma ◽  
Case Series ◽  
Malignant Neoplasm ◽  
Benign Tumors ◽  
Imaging Features ◽  
Primary Tumors ◽  
Therapeutic Decisions ◽  
Tumors Of The Hand

: Musculoskeletal tumors of the hand are a rare entity and are divided into skeletal and soft tissue tumors. Either category comprises benign and malignant or even intermediate tumors. Basic radiology allows an optimal resolution of bone and related soft tissue areas, ultrasound and more sophisticated radiologic tools such as scintigraphy, CT and MRI allow a more accurate evaluation of tumor extent. Enchondroma is the most common benign tumor affecting bone, whereas chondrosarcoma is the most commonly represented malignant neoplasm localized to hand bones. In the soft tissues ganglions are the most common benign tumors and epithelioid sarcoma is the most frequently represented malignant tumor targeting hand soft tissues. The knowledge regarding diagnostic and therapeutic management of these tumors is often deriving from small case series, retrospective studies or even case reports. Evidences from prospective studies or controlled trials are limited and for this lack of clear and supported evidences data from the medical literature on the topic are controversial, in terms of demographics, clinical presentation, diagnosis prognosis and therapy.The correct recognition of the specific subtype and extension of the tumor through first line and second line radiology is essential for the surgeon, in order to effectively direct the therapeutic decisions.

scholarly journals Unusual sites of bone involvement in Langerhans cell histiocytosis: a systematic review of the literature

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Nahid Reisi ◽  
Pouran Raeissi ◽  
Touraj Harati Khalilabad ◽  
Alireza Moafi
Keyword(s):  
Systematic Review ◽  
Dendritic Cells ◽  
Rare Disease ◽  
Langerhans Cell Histiocytosis ◽  
Case Reports ◽  
Langerhans Cell ◽  
The Other ◽  
Bone Involvement ◽  
Intracranial Extension ◽  
Pathologic Fractures

Abstract Background Langerhans cell histiocytosis (LCH) is a rare disease that originates from the uncontrolled proliferation and accumulation of bone marrow-derived immature myeloid dendritic cells. Dendritic cells are a type of histiocyte that play an important role in the human immune system and are found in the bone, skin, stomach, eyes, intestines, and lungs. Objective This systematic review aimed to collect and report published case reports of rare bone disease caused by LCH to avoid misdiagnoses or delays in diagnosis. Methods We systematically searched Scopus, PubMed, Embase, and Web of Sciences from August 1, 2000 to December 31, 2019. Studies reporting cases of LCH with rare bone involvement were included. Results We identified 60 articles including 64 cases. Of the identified cases, 31 (48.4%) involved children, and 33 (51.6%) involved adults. Additionally, 46.9% (30 individuals) were from Asian countries. The mean age of the children was 7.6 ± 4.3 years and that of the adults was 36 ± 12 years. The findings indicated that unifocal bone involvements were the most prevalent form of the disease (68.7%), and, overall, the skull and chest wall were the most commonly affected bones in both adults and children. The spine and long bones were the second most commonly affected bones in children, and the spine and jaw were the second most commonly affected bones in adults. Pain and swelling were the most frequent presenting signs among the investigated cases, and loss of consciousness, myelopathy, nerve palsy, visual loss, torticollis and clicking sounds were rare signs. Osteolytic lesions were the most frequent radiologic feature (62.5%), and intracranial hemorrhage, fluid–fluid level, dura and intracranial extension and pathologic fractures were rare radiological features. Total excision, curettage and observation in the unifocal group of patients and systemic chemotherapy in the other groups (i.e., multifocal and multisystem) were the most frequent management approaches. The recovery rates of the unifocal and multifocal groups were 77.3% and 81.8%, respectively, while that of the multisystem group was 55.5%. The rates of recurrence and mortality in the multisystem group were 11% and were higher than those in the other groups. Conclusions LCH is a rare disease that can affect any organ in the human body. However, bone is the most commonly involved organ, and rare bone involvements may be the first or only symptom of the disease due to the rarity of such lesions; a lack of familiarity with them may result in misdiagnosis or delayed diagnosis.

Prognosis of patients in prolonged coma after severe carbon monoxide poisoning

2021 ◽  
pp. 096032712199799
Author(s):  
Y Gao ◽  
H Gu ◽  
J Yang ◽  
L Yang ◽  
Z Li ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Poor Prognosis ◽  
Vegetative State ◽  
Carbon Monoxide Poisoning ◽  
Demographic Data ◽  
Laboratory Data ◽  
Persistent Vegetative State ◽  
Chronic Phase ◽  
Imaging Features ◽  
Prolonged Coma

Background: Late recovery in patients following prolonged coma from carbon monoxide poisoning have been reported, but the probability is unclear. The purpose of this research was to assess the prognosis of patients in prolonged coma after severe carbon monoxide poisoning and related clinical and imaging features. Methods: There were 13 patients who had been in a state of coma for >7 days after acute carbon monoxide poisoning in the retrospective observational study, and demographic data, clinical data, laboratory data, complications, and image data were collected. Outcome was assessed by means of the Glasgow outcome scale after 1 year. The relationship between complications and imaging manifestations and prognosis was also analyzed. Results: One year after severe carbon monoxide poisoning, two patients (15.4%) had died (GOS 1), nine (69.2%) were in a persistent vegetative state (GOS 2), one (7.7%) was moderately disabled (GOS 4), and one (7.7%) achieved a good recovery (GOS 5) with minimal disability. Conclusions: Most patients with prolonged coma after severe carbon monoxide poisoning had a poor prognosis, although the younger patients had a better prognosis. Respiratory failure, hypotension and renal failure during the course of the disease were associated with a poor prognosis. The prognosis of patients with injuries in two sites in early CT was poor. Multiple lesions (≥3) and extensive white matter damage (Fazekas grade (PVH or DWMH) = 3) on MRI of chronic phase were also associated with a poor prognosis.

scholarly journals Small Cell Ovarian Cancer in Adolescents: Report of Two Cases and Review of the Literature

2011 ◽  
Vol 2011 ◽  
pp. 1-4 ◽  
Author(s):  
M. Rovithi ◽  
A. G. Pallis ◽  
A. Kalykaki ◽  
E. Lagoudaki ◽  
L. Giannikaki ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Combination Chemotherapy ◽  
Poor Prognosis ◽  
Relevant Literature ◽  
Malignant Neoplasm ◽  
Standard Of Care ◽  
Small Cell ◽  
Review Of The Literature

Ovarian small cell carcinoma is a rare and highly malignant neoplasm carrying a poor prognosis. Although combination chemotherapy remains the cornerstone of treatment due to the rarity of these tumors, no regimen can be recommended as standard of care although in the majority of cases platinum-based regimens are used. Herein, we report two cases of small cell carcinoma of the ovaries along with a review of the relevant literature.

An Unusual Case of Desmoplastic Melanoma With Monster Cells Imitating an Atypical Fibroxanthoma

2021 ◽  
pp. 106689692110447
Author(s):  
Juan J. Ríos-Martín ◽  
Manuel Pérez-Pérez ◽  
Sebastián Umbría-Jiménez ◽  
David Moreno-Ramírez ◽  
Ana Vallejo-Benítez
Keyword(s):  
Cyclin D1 ◽  
Copy Number ◽  
Poor Prognosis ◽  
Unusual Case ◽  
Prognostic Significance ◽  
Mutation Status ◽  
Atypical Fibroxanthoma ◽  
Desmoplastic Melanoma ◽  
Aggressive Tumor

Numerous cells with very large and irregular nuclei (“monster” cells) have not hitherto been reported in desmoplastic melanoma (DM). Their prognostic significance in melanomas is a matter of debate, although some authors have associated them with more aggressive tumor behavior. We report a mixed DM on the scalp of an 88-year-old woman imitating an atypical fibroxanthoma. Tumor cells stained positive for SOX10, S100, and cyclin D1; BRAF mutation status was negative, and fluorescence in situ hybridization analysis showed copy number gains in 11q13 (cyclin D1) and 6p25 (RREB1), and loss in 6q23 (MYB). Cyclin D1 amplification is associated with poor prognosis in melanoma.

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