scholarly journals MRI-Visible Perivascular Spaces in the Centrum Semiovale Are Associated with Brain Amyloid Deposition in Patients with Alzheimer Disease–Related Cognitive Impairment

2021 ◽  
Author(s):  
H.J. Kim ◽  
H. Cho ◽  
M. Park ◽  
J.W. Kim ◽  
S.J. Ahn ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Alzheimer Disease ◽  
Amyloid Deposition ◽  
Perivascular Spaces ◽  
Centrum Semiovale ◽  
Brain Amyloid Deposition

Asymmetric Amyloid Deposition as an Early Sign of Progression in Mild Cognitive Impairment Due to Alzheimer Disease

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Hai-Jeon Yoon ◽  
Bom Sahn Kim ◽  
Jee Hyang Jeong ◽  
Geon Ha Kim ◽  
Hee Kyung Park ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Alzheimer Disease ◽  
Amyloid Deposition ◽  
Early Sign

scholarly journals Dissociation between Brain Amyloid Deposition and Metabolism in Early Mild Cognitive Impairment

PLoS ONE ◽  
2012 ◽  
Vol 7 (10) ◽  
pp. e47905 ◽  
Author(s):  
Liyong Wu ◽  
Jared Rowley ◽  
Sara Mohades ◽  
Antoine Leuzy ◽  
Marina Tedeschi Dauar ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Amyloid Deposition ◽  
Early Mild Cognitive Impairment ◽  
Brain Amyloid Deposition

IC-P-006: Brain amyloid deposition and metabolism in early and late mild cognitive impairment

2012 ◽  
Vol 8 (4S_Part_1) ◽  
pp. P12-P13
Author(s):  
Jared Rowley ◽  
Liyong Wu ◽  
Sara Mohades ◽  
Marina Dauar ◽  
Antoine Leuzy ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Amyloid Deposition ◽  
Brain Amyloid Deposition

scholarly journals Relationship between Cerebrospinal Fluid Matrix Metalloproteinases Levels and Brain Amyloid Deposition in Mild Cognitive Impairment

Biomolecules ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 1496
Author(s):  
Yuuki Sasaki ◽  
Noriyuki Kimura ◽  
Yasuhiro Aso ◽  
Kenichi Yabuuchi ◽  
Miki Aikawa ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Cerebrospinal Fluid ◽  
Cognitive Impairment ◽  
Amyloid Deposition ◽  
Emission Tomography ◽  
Cingulate Gyrus ◽  
Posterior Cingulate Gyrus ◽  
Positron Emission ◽  
Csf Levels ◽  
Brain Amyloid Deposition

This study aimed to explore whether cerebrospinal fluid (CSF) levels of matrix metalloproteinases (MMPs), and their inhibitors (TIMPs) were associated with brain amyloid deposition, cortical glucose metabolism, and white matter lesions (WMLs) in individuals with amnestic mild cognitive impairment (MCI). A total of 33 individuals with amnestic MCI (mean age, 75.6 years) underwent 11C-Pittsburgh compound B positron emission tomography (PiB-PET), 18F-fluorodeoxyglucose positron emission tomography, magnetic resonance imaging or computed tomography, and CSF analysis. PET uptake of the frontal and temporoparietal lobes and posterior cingulate gyrus was assessed using the cerebellar cortex as the reference region. WMLs were assessed by the Fazekas scale. CSF levels of MMPs and TIMPs were measured with bead-based multiplex assays. After adjusting for covariates, multiple linear regression analysis showed that CSF levels of MMP-2 were negatively correlated with global PiB uptake (p = 0.035), especially in the parietotemporal lobe and posterior cingulate gyrus (p = 0.016 and p = 0.041, respectively). Moreover, CSF levels of MMP-7 were positively correlated with the severity of WMLs (p = 0.033). CSF levels of MMP-2 and MMP-7 are associated with brain amyloid deposition and severity of WMLs, respectively. These findings provide valuable insights into the role of MMPs in amyloid β catabolism and blood–brain barrier integration at the MCI stage.

Cerebral Amyloid Angiopathy in Amyloid-Positive Patients from a Memory Clinic Cohort

2021 ◽  
Vol 79 (4) ◽  
pp. 1661-1672
Author(s):  
Ana Sofia Costa ◽  
João Pinho ◽  
Domantė Kučikienė ◽  
Arno Reich ◽  
Jörg B. Schulz ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Cognitive Decline ◽  
Cerebral Amyloid Angiopathy ◽  
Clinical Severity ◽  
Amyloid Angiopathy ◽  
Perivascular Spaces ◽  
Memory Clinic ◽  
Centrum Semiovale ◽  
Cerebral Amyloid

Background: The overlap between cerebral amyloid angiopathy (CAA) and Alzheimer’s disease (AD) is frequent and relevant for patients with cognitive impairment. Objective: To assess the role of the diagnosis of CAA on the phenotype of amyloid-β (Aβ) positive patients from a university-hospital memory clinic. Methods: Consecutive patients referred for suspected cognitive impairment, screened for Aβ pathological changes in cerebrospinal fluid (CSF), with available MRI and neuropsychological results were included. We determined the association between probable CAA and clinical, neuropsychological (at presentation and after a mean follow-up of 17 months in a sub-sample) and MRI (atrophy, white matter hyperintensities, perivascular spaces) characteristics. Results: Of 218 amyloid-positive patients, 8.3% fulfilled criteria for probable CAA. A multivariable logistic regression showed an independent association of probable CAA with lower Aβ1–42 (adjusted odds ratio [aOR] = 0.94, 95% confidence interval [95% CI] = 0.90–0.98, p = 0.003), and Aβ1–40 (aOR = 0.98, 95% CI=0.97–0.99 p = 0.017) levels in CSF, and presence of severe burden of enlarged perivascular spaces (EPVS) in the centrum semiovale (aOR = 3.67, 95% CI = 1.21–11.15, p = 0.022). Linear mixed-model analysis showed that both groups significantly deteriorated in global clinical severity, executive function and memory. Nevertheless, the presence of probable CAA did not differently affect the rate of cognitive decline. Conclusion: The presence of probable CAA in Aβ positive patients was associated with lower Aβ1–42 and Aβ1–40 CSF levels and increased centrum semiovale EPVS burden, but did not independently influence clinical phenotype nor the rate of cognitive decline within our follow-up time window.

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