scholarly journals The Distribution and Role of M1 and M2 Macrophages in Aneurysm Healing after Platinum Coil Embolization

2020 ◽  
Author(s):  
Z. Khashim ◽  
D. Daying ◽  
D.Y. Hong ◽  
J.A. Ringler ◽  
S. Herting ◽  
...  
Keyword(s):  
Coil Embolization ◽  
M2 Macrophages ◽  
Platinum Coil ◽  
M1 And M2 Macrophages

scholarly journals Molecular and Cellular Impact of Inflammatory Extracellular Vesicles (EVs) Derived from M1 and M2 Macrophages on Neural Action Potentials

2020 ◽  
Vol 10 (7) ◽  
pp. 424
Author(s):  
Sarah Vakili ◽  
Taha Mohseni Ahooyi ◽  
Shadan S. Yarandi ◽  
Martina Donadoni ◽  
Jay Rappaport ◽  
...  
Keyword(s):  
Extracellular Vesicles ◽  
Immune Cells ◽  
Action Potentials ◽  
M2 Macrophage ◽  
M2 Macrophages ◽  
Neuronal Functions ◽  
The Brain ◽  
Macrophage Subtypes ◽  
M1 And M2 Macrophages

Several factors can contribute to neuroinflammatory disorders, such as cytokine and chemokines that are produced and released from peripherally derived immune cells or from locally activated cells such as microglia and perivascular macrophages in the brain. The primary function of these cells is to clear inflammation; however, following inflammation, circulating monocytes are recruited to the central nervous system (CNS). Monocyte-derived macrophages in the CNS play pivotal roles in mediating neuroinflammatory responses. Macrophages are heterogeneous both in normal and in pathological conditions due to their plasticity, and they are classified in two main subsets, classically activated (M1) or alternatively activated (M2). There is accumulating evidence suggesting that extracellular vesicles (EVs) released from activated immune cells may play crucial roles in mediating inflammation. However, a possible role of EVs released from immune cells such as M1 and M2 macrophages on neuronal functions in the brain is not known. In order to investigate the molecular and cellular impacts of macrophages and EVs released from macrophage subtypes on neuronal functions, we used a recently established in vitro M1 and M2 macrophage culture model and isolated and characterized EVs from these macrophage subtypes, treated primary neurons with M1 or M2 EVs, and analyzed the extracellular action potentials of neurons with microelectrode array studies (MEA). Our results introduce evidence on the interfering role of inflammatory EVs released from macrophages in interneuronal signal transmission processes, with implications in the pathogenesis of neuroinflammatory diseases induced by a variety of inflammatory insults.

scholarly journals Polarized Macrophages in Periodontitis: Characteristics, Function, and Molecular Signaling

2021 ◽  
Vol 12 ◽  
Author(s):  
Xiaoyu Sun ◽  
Jike Gao ◽  
Xiang Meng ◽  
Xiaoxuan Lu ◽  
Lei Zhang ◽  
...  
Keyword(s):  
Macrophage Polarization ◽  
Research Progress ◽  
Periodontal Tissue ◽  
M2 Macrophages ◽  
Molecular Signaling ◽  
Local Inflammatory Response ◽  
Anti Inflammatory ◽  
M1 Type ◽  
M1 And M2 Macrophages

Periodontitis (PD) is a common chronic infectious disease. The local inflammatory response in the host may cause the destruction of supporting periodontal tissue. Macrophages play a variety of roles in PD, including regulatory and phagocytosis. Moreover, under the induction of different factors, macrophages polarize and form different functional phenotypes. Among them, M1-type macrophages with proinflammatory functions and M2-type macrophages with anti-inflammatory functions are the most representative, and both of them can regulate the tendency of the immune system to exert proinflammatory or anti-inflammatory functions. M1 and M2 macrophages are involved in the destructive and reparative stages of PD. Due to the complex microenvironment of PD, the dynamic development of PD, and various local mediators, increasing attention has been given to the study of macrophage polarization in PD. This review summarizes the role of macrophage polarization in the development of PD and its research progress.

scholarly journals The role of macrophages in the formation of hypertrophic scars and keloids

2020 ◽  
Vol 8 ◽  
Author(s):  
Xiangwen Xu ◽  
Shuchen Gu ◽  
Xin Huang ◽  
Jieyi Ren ◽  
Yihui Gu ◽  
...  
Keyword(s):  
Late Stage ◽  
Early Stage ◽  
Scar Formation ◽  
M2 Macrophages ◽  
Hypertrophic Scars ◽  
Prediction And Prevention ◽  
Invasive Property ◽  
Pathological Scar ◽  
M1 And M2 Macrophages

Abstract Numerous studies have shown that macrophages can orchestrate the microenvironment from the early stage of wound healing to the later stages of scar formation. However, few reviews have highlighted the significance of macrophages during the formation of abnormal scars. The purpose of this review was to outline the polarization of macrophages from early to late stage of pathological scar formation, focusing on spatiotemporal diversity of M1 and M2 macrophages. In this review, the role of macrophages in the formation of hypertrophic scars and keloids is summarized in detail. First, an increased number of M2 cells observed before injuries are significantly associated with susceptibility to abnormal scar pathogenesis. Second, decreased expression of M1 at the early stage and delayed expression of M2 at the late stage results in pathological scar formation. Third, M2 cells are highly expressed at both the margin and the superficial region, which is consistent with the invasive property of keloids. Finally, this review helps to characterize strategies for the prediction and prevention of pathological scar formation.

High glucose induces donors-specific cytokine response in primary human M1 and M2 macrophages

2015 ◽  
Vol 10 (S 01) ◽  
Author(s):  
K Moganti ◽  
F Li ◽  
S Riehman ◽  
H Klüter ◽  
M Harmsen ◽  
...  
Keyword(s):  
High Glucose ◽  
Cytokine Response ◽  
M2 Macrophages ◽  
M1 And M2 Macrophages

scholarly journals VitA or VitD ameliorates bronchopulmonary dysplasia by regulating the balance between M1 and M2 macrophages

2021 ◽  
Vol 141 ◽  
pp. 111836
Author(s):  
Hong Zhen ◽  
Hongbo Hu ◽  
Guojie Rong ◽  
Xiuxiu Huang ◽  
Chang Tan ◽  
...  
Keyword(s):  
Bronchopulmonary Dysplasia ◽  
M2 Macrophages ◽  
M1 And M2 Macrophages

Intrasaccular Detachable Platinum Coil Embolization for Traumatic Pseudoaneurysm Treatment of a Cavernous Carotid Artery

2001 ◽  
Vol 124 (2) ◽  
pp. 230-231 ◽  
Author(s):  
Sung-Won Chae ◽  
Geon Choi ◽  
Heung-Man Lee ◽  
Jae-Jun Song ◽  
Jong-Ouck Choi ◽  
...  
Keyword(s):  
Carotid Artery ◽  
Coil Embolization ◽  
Platinum Coil ◽  
Traumatic Pseudoaneurysm ◽  
Cavernous Carotid Artery

Percutaneous Superselective Coil-Embolization of Intrarenal Arteriovenous Fistulas

1996 ◽  
Vol 37 (3P2) ◽  
pp. 539-541 ◽  
Author(s):  
H. Husstedt ◽  
A. Chavan ◽  
F. Ghadban ◽  
A. Leppert ◽  
M. Galanski
Keyword(s):  
Coil Embolization ◽  
Av Fistula ◽  
Arteriovenous Fistulas ◽  
Percutaneous Catheter ◽  
Coil Occlusion ◽  
Av Fistulas ◽  
Small Parts

Purpose: To evaluate the role of percutaneous transcatheter coil-occlusion in the management of uncontrollable postoperative hematuria due to iatrogenic arteriovenous (AV) fistula. Material and Methods: In 2 patients, AV fistulas were occluded with percutaneous catheter-guided superselective coil embolization. Results: In both cases, occlusion of the AV fistulas was successful. Only small parts (less than 10%) of the parenchyma had to be sacrificed. No hypertension occurred. Conclusion: Percutaneous coil embolization is a useful alternative to surgery in cases of postoperative AV fistulas. Hematuria can be effectively controlled without resulting hypertension.

Sign in / Sign up

Export Citation Format

Share Document