scholarly journals Hemodynamic Analysis of Postoperative Rupture of Unruptured Intracranial Aneurysms after Placement of Flow-Diverting Stents: A Matched Case-Control Study

2019 ◽  
Author(s):  
W. Li ◽  
Z. Tian ◽  
W. Zhu ◽  
Y.S. Zhang ◽  
K. Wang ◽  
...  
Keyword(s):  
Intracranial Aneurysms ◽  
Case Control Study ◽  
Case Control ◽  
Unruptured Intracranial Aneurysms ◽  
Matched Case ◽  
Matched Case Control Study ◽  
Control Study

scholarly journals Rupture prediction of intracranial aneurysms: a nationwide matched case-control study of hemodynamics at the time of diagnosis

2018 ◽  
Vol 129 (4) ◽  
pp. 854-860 ◽  
Author(s):  
Torbjørn Øygard Skodvin ◽  
Øyvind Evju ◽  
Christian A. Helland ◽  
Jørgen Gjernes Isaksen
Keyword(s):  
Shear Stress ◽  
Wall Shear Stress ◽  
Intracranial Aneurysms ◽  
Case Control Study ◽  
Univariate Analysis ◽  
Case Control ◽  
Matched Case ◽  
Wall Shear ◽  
Matched Case Control Study ◽  
Control Study

OBJECTIVEHemodynamic rupture predictors in intracranial aneurysms (IAs) must be investigated in prerupture aneurysms, because rupture might significantly alter aneurysm hemodynamics. Both clinical and aneurysmal factors influence hemodynamics, possibly confounding results in unmatched patient materials. The authors aimed to identify hemodynamic variables at the time of diagnosis that could be associated with IA rupture.METHODSA nationwide matched case-control study of IA hemodynamics at the time of diagnosis was performed. Twelve IAs that later ruptured were matched 1:2 with control aneurysms that remained unruptured during a median follow-up time of 4.5 years (interquartile range 3.7–8.2 years). Cases and controls were matched by aneurysm location and size, and patient sex and age. Hemodynamic parameters were obtained from computational fluid dynamics simulations.RESULTSThe low shear area (LSA) was significantly higher in cases than in controls in univariate analysis (p = 0.041). Minimum logarithmic wall shear stress, averaged logarithmic wall shear stress, pressure loss coefficient, and inflow concentration index showed a tendency to be associated with later rupture (p = 0.09, 0.14, 0.15, and 0.18, respectively). The LSA remained statistically significant in multivariable analysis (p = 0.030).CONCLUSIONSHemodynamics at the time of diagnosis are different in aneurysms that later rupture than in those that remain unruptured. Increased LSA might be an early predictor of rupture.

Dietary and serum vitamin D and preeclampsia risk in Chinese pregnant women: a matched case–control study

2021 ◽  
pp. 1-26
Author(s):  
Xue-min Huang ◽  
Yan-hua Liu ◽  
Han Zhang ◽  
Yuan Cao ◽  
Wei-feng Dou ◽  
...  
Keyword(s):  
Vitamin D ◽  
Dietary Intake ◽  
Pregnant Women ◽  
Case Control Study ◽  
Serum Levels ◽  
Case Control ◽  
Serum Concentrations ◽  
Matched Case ◽  
Matched Case Control Study ◽  
Control Study

Abstract The effect of vitamin D (VD) on the risk of preeclampsia (PE) is uncertain. Few of previous studies focused on the relationship between dietary VD intake and PE risk. Therefore, we conducted this 1:1 matched case-control study to explore the association of dietary VD intake and serum VD concentrations with PE risk in Chinese pregnant women. A total of 440 pairs of participants were recruited during March 2016 to June 2019. Dietary information was obtained using a 78-item semi-quantitative food frequency questionnaire. Serum concentrations of 25(OH)D2 and 25(OH)D3 were measured by liquid chromatography–tandem mass spectrometry. Multivariate conditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Restricted cubic splines (RCS) were plotted to evaluate the dose-response relationship of dietary VD intake and serum VD concentrations with PE risk. Compared with the lowest quartile, the ORs of the highest quartile were 0.45 (95%CI: 0.29-0.71, Ptrend = 0.001) for VD dietary intake and 0.26 (95%CI: 0.11-0.60, Ptrend = 0.003) for serum levels after adjusting for confounders. In addition, the RCS analysis suggested a reverse J-shaped relationship between dietary VD intake and PE risk (P-nonlinearity = 0.02). A similar association was also found between serum concentrations of total 25(OH)D and PE risk (P-nonlinearity = 0.02). In conclusion, this study provides evidence that higher dietary intake and serum levels of VD are associated with the lower risk of PE in Chinese pregnant women.

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