scholarly journals Altered Relationship between Working Memory and Brain Microstructure after Mild Traumatic Brain Injury

2019 ◽  
Author(s):  
S. Chung ◽  
X. Wang ◽  
E. Fieremans ◽  
J.F. Rath ◽  
P. Amorapanth ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Working Memory ◽  
Brain Injury ◽  
Mild Traumatic Brain Injury ◽  
Brain Microstructure

scholarly journals Modulation of working memory load distinguishes individuals with and without balance impairments following mild traumatic brain injury

Brain Injury ◽  
2017 ◽  
Vol 32 (2) ◽  
pp. 191-199 ◽  
Author(s):  
Elizabeth J. Woytowicz ◽  
Chandler Sours ◽  
Rao P. Gullapalli ◽  
Joseph Rosenberg ◽  
Kelly P. Westlake
Keyword(s):  
Traumatic Brain Injury ◽  
Working Memory ◽  
Brain Injury ◽  
Mild Traumatic Brain Injury ◽  
Memory Load ◽  
Working Memory Load

scholarly journals Effect of Age on Working Memory Performance and Cerebral Activation after Mild Traumatic Brain Injury: A Functional MR Imaging Study

Radiology ◽  
2016 ◽  
Vol 278 (3) ◽  
pp. 854-862 ◽  
Author(s):  
David Yen-Ting Chen ◽  
Hui-Ling Hsu ◽  
Ying-Sheng Kuo ◽  
Changwei Wesley Wu ◽  
Wen-Ta Chiu ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Working Memory ◽  
Brain Injury ◽  
Mr Imaging ◽  
Mild Traumatic Brain Injury ◽  
Memory Performance ◽  
Imaging Study ◽  
Cerebral Activation ◽  
Functional Mr Imaging ◽  
Effect Of Age

scholarly journals Alpha-2 adrenergic challenge with guanfacine one month after mild traumatic brain injury: Altered working memory and BOLD response

2011 ◽  
Vol 82 (1) ◽  
pp. 107-114 ◽  
Author(s):  
Thomas W. McAllister ◽  
Brenna C. McDonald ◽  
Laura A. Flashman ◽  
Richard B. Ferrell ◽  
Tor D. Tosteson ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Working Memory ◽  
Brain Injury ◽  
Mild Traumatic Brain Injury ◽  
Bold Response

scholarly journals Alpha desynchronization/synchronization during working memory testing is compromised in acute mild traumatic brain injury (mTBI)

PLoS ONE ◽  
2018 ◽  
Vol 13 (2) ◽  
pp. e0188101 ◽  
Author(s):  
Xianghong Arakaki ◽  
Michael Shoga ◽  
Lianyang Li ◽  
George Zouridakis ◽  
Thao Tran ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Working Memory ◽  
Brain Injury ◽  
Mild Traumatic Brain Injury ◽  
Memory Testing

scholarly journals Impaired visual working memory and reduced connectivity in undergraduates with a history of mild traumatic brain injury

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Hector Arciniega ◽  
Jorja Shires ◽  
Sarah Furlong ◽  
Alexandrea Kilgore-Gomez ◽  
Adelle Cerreta ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Working Memory ◽  
Brain Injury ◽  
Mild Traumatic Brain Injury ◽  
Resting State Fmri ◽  
Underlying Mechanism ◽  
Post Injury ◽  
Behavioral Deficits ◽  
Specific Outcome ◽  
History Of

AbstractMild traumatic brain injury (mTBI), or concussion, accounts for 85% of all TBIs. Yet survivors anticipate full cognitive recovery within several months of injury, if not sooner, dependent upon the specific outcome/measure. Recovery is variable and deficits in executive function, e.g., working memory (WM) can persist years post-mTBI. We tested whether cognitive deficits persist in otherwise healthy undergraduates, as a conservative indicator for mTBI survivors at large. We collected WM performance (change detection, n-back tasks) using various stimuli (shapes, locations, letters; aurally presented numbers and letters), and wide-ranging cognitive assessments (e.g., RBANS). We replicated the observation of a general visual WM deficit, with preserved auditory WM. Surprisingly, visual WM deficits were equivalent in participants with a history of mTBI (mean 4.3 years post-injury) and in undergraduates with recent sports-related mTBI (mean 17 days post-injury). In seeking the underlying mechanism of these behavioral deficits, we collected resting state fMRI (rsfMRI) and EEG (rsEEG). RsfMRI revealed significantly reduced connectivity within WM-relevant networks (default mode, central executive, dorsal attention, salience), whereas rsEEG identified no differences (modularity, global efficiency, local efficiency). In summary, otherwise healthy current undergraduates with a history of mTBI present behavioral deficits with evidence of persistent disconnection long after full recovery is expected.

Prediction of cognitive sequelae based on abnormal computed tomography findings in children following mild traumatic brain injury

2008 ◽  
Vol 1 (6) ◽  
pp. 461-470 ◽  
Author(s):  
Harvey S. Levin ◽  
Gerri Hanten ◽  
Garland Roberson ◽  
Xiaoqi Li ◽  
Linda Ewing-Cobbs ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Traumatic Brain Injury ◽  
Working Memory ◽  
Brain Injury ◽  
Mild Traumatic Brain Injury ◽  
Longitudinal Design ◽  
Ct Scans ◽  
Body Regions ◽  
Ct Findings ◽  
Prospective Longitudinal

Object The aim of this study was to determine whether the presence of intracranial pathophysiology on computed tomography (CT) scans obtained within 24 hours of mild traumatic brain injury (MTBI) in children adversely affects neuropsychological outcome during the 1st year postinjury. Methods A prospective longitudinal design was used to examine the neuropsychological outcomes in children (ages 5–15 years) who had been treated for MTBI, which was defined as a loss of consciousness for up to 30 minutes and a lowest Glasgow Coma Scale (GCS) score of 13–15. Exclusion criteria included any preinjury neurological disorder. Outcome assessments were performed within 2 weeks and at 3, 6, and 12 months postinjury. Outcomes were compared between patients with MTBI whose postinjury CT scans revealed complications of brain pathophysiology (32 patients, CMTBI group) and those with MTBI but without complications (48 patients, MTBI group). Results Significant interactions confirmed that the pattern of recovery over 12 months after injury differed depending on the intracranial pathology, presence and severity of injuries to body regions other than the head, preinjury attention-deficit hyperactivity disorder (ADHD), and socioeconomic status. Children in the CMTBI group had significantly poorer episodic memory, slower cognitive processing, diminished recovery in managing cognitive interference, and poorer performance in calculating and reading than patients in the MTBI group. Among the patients with mild or no extracranial injury, visuomotor speed was slower in those in the CMTBI group; and among patients without preinjury ADHD, working memory was worse in those in the CMTBI group. Conclusions Neuropsychological recovery during the 1st year following MTBI is related to the presence of radiographically detectable intracranial pathology. Children with intracranial pathology on acute CT performed more poorly in several cognitive domains when compared with patients whose CT findings were normal or limited to a linear skull fracture. Depending on the presence of preinjury ADHD and concomitant extracranial injury, working memory and visuomotor speed were also diminished in patients whose CT findings revealed complications following MTBI. Computed tomography within 24 hours postinjury appears to be useful for identifying children with an elevated risk for residual neuropsychological changes.

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