scholarly journals Improving Detection of Multiple Sclerosis Lesions in the Posterior Fossa Using an Optimized 3D-FLAIR Sequence at 3T

2019 ◽  
Vol 40 (7) ◽  
pp. 1170-1176 ◽  
Author(s):  
A. Lecler ◽  
I. El Sanharawi ◽  
J. El Methni ◽  
O. Gout ◽  
P. Koskas ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Posterior Fossa ◽  
Flair Sequence ◽  
3D Flair

scholarly journals Can white matter lesion burden predict involvement of normal appearing thalami in multiple sclerosis? Study using 3D FLAIR and DTI

2021 ◽  
Vol 52 (1) ◽  
Author(s):  
Mohamed D. Homos
Keyword(s):  
Multiple Sclerosis ◽  
White Matter ◽  
White Matter Lesion ◽  
White Matter Lesions ◽  
Imaging Protocol ◽  
Flair Sequence ◽  
Highly Sensitive ◽  
Microscopic Damage ◽  
Standardized Imaging Protocol ◽  
3D Flair

Abstract Background Multiple sclerosis is a chronic demyelinating disease that affects the white and grey matter. The thalamus is responsible for many neurological functions, and it is liable to damage in multiple sclerosis in the absence of MRI-detectable thalamic lesions. Standardized imaging protocol for multiple sclerosis includes 3D FLAIR sequence that is highly sensitive in detecting white matter lesions. Owing to the thalamic functional importance, we aim in this study to show to what extent the standardized imaging protocol (3D FLAIR) can predict microscopic damage of normal appearing thalami, depending on DTI metrics (ADC and FA) as indicators of the microscopic damage. Results We examined 42 multiple sclerosis patients, 16 males and 26 females, with mean age 29 ± 6 years using 3D FLAIR sequence to delineate the white matter lesions and calculate their total areas and using DTI to calculate the average ADC and FA values of the thalami. Spearman’s correlation coefficient (r) was used to correlate between the white matter lesion burden and the thalamic diffusivity (ADC and FA). Moderate correlation was found between average ADC values of the thalami and the total white matter lesion areas (r = 0.5, p = 0.03). Very weak correlation was found between average FA values of the thalami and the total white matter lesion areas (r = − 0.1, p = 0.6) Conclusion White matter lesion burden detected using the highly sensitive 3D FLAIR sequence does not always correlate with the microstructural damage in normal appearing thalami. DTI needs to be added to the examination protocol if damage of normal appearing thalami is of concern.

scholarly journals Longitudinal Persistence of Meningeal Enhancement on Postcontrast 7T 3D-FLAIR MRI in Multiple Sclerosis

2018 ◽  
Vol 39 (10) ◽  
pp. 1799-1805 ◽  
Author(s):  
S.N. Jonas ◽  
I. Izbudak ◽  
A.A. Frazier ◽  
D.M. Harrison
Keyword(s):  
Multiple Sclerosis ◽  
Meningeal Enhancement ◽  
3D Flair

Assessment of sedated pediatric brain with 3D-FLAIR sequence at 3T MRI

2015 ◽  
Vol 37 (5) ◽  
pp. 495-500 ◽  
Author(s):  
Umit Aksoy Ozcan ◽  
Ugur Isik ◽  
Alp Ozpinar ◽  
Nigar Baykan ◽  
Alp Dincer
Keyword(s):  
3T Mri ◽  
Flair Sequence ◽  
Pediatric Brain ◽  
3D Flair

Detection of lesions in multiple sclerosis by 2D FLAIR and single-slab 3D FLAIR sequences at 3.0 T: initial results

2006 ◽  
Vol 16 (5) ◽  
pp. 1104-1110 ◽  
Author(s):  
Andrea Bink ◽  
Melanie Schmitt ◽  
Jochen Gaa ◽  
John P. Mugler ◽  
Heinrich Lanfermann ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
3.0 T ◽  
Initial Results ◽  
3D Flair

Patient-specific 3D FLAIR for enhanced visualization of brain white matter lesions in multiple sclerosis

2016 ◽  
Vol 46 (2) ◽  
pp. 557-564
Author(s):  
Refaat E. Gabr ◽  
Amol S. Pednekar ◽  
Koushik A. Govindarajan ◽  
Xiaojun Sun ◽  
Roy F. Riascos ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
White Matter ◽  
White Matter Lesions ◽  
Patient Specific ◽  
Brain White Matter ◽  
3D Flair

scholarly journals An Automatic Segmentation of T2-FLAIR Multiple Sclerosis Lesions

2008 ◽  
Author(s):  
Jean-christophe Souplet ◽  
Christine Lebrun ◽  
Nicholas Ayache ◽  
Gregoire Malandain
Keyword(s):  
Multiple Sclerosis ◽  
Test Data ◽  
Automatic Segmentation ◽  
Challenge Test ◽  
Flair Sequence ◽  
Conventional Mri ◽  
Hyperintense Signal ◽  
Automatic Methods ◽  
Mri Sequences

Multiple sclerosis diagnosis and patient follow-up can be helped by an evaluation of the lesion load in MRI sequences. A lot of automatic methods to segment these lesions are available in the literature. The MICCAI workshop Multiple Sclerosis (MS) lesion segmentation Challenge 08 allows to test and compare these algorithms. This paper presents a method designed to detect hyperintense signal area on T2-FLAIR sequence and its results on the Challenge test data. The proposed algorithm uses only three conventional MRI sequences: T1, T2 and T2-FLAIR. First, images are cropped, spatially unbiased and skull-stripped. A segmentation of the brain into its different compartments is performed on the T1 and the T2 sequences. From these segmentations, a threshold for the T2-FLAIR sequence is automatically computed. Then postprocessing operations select the most plausible lesions in the obtained hyperintense signals. Global result on the test data (80/100) is close to the inter-expert variability (90/100).

The round window sign: a sensitive sign to detect perilymphatic fistulae on delayed postcontrast 3D-FLAIR sequence

2020 ◽  
Vol 30 (11) ◽  
pp. 6303-6310 ◽  
Author(s):  
Frédérique Dubrulle ◽  
Victor Chaton ◽  
Michael Risoud ◽  
Hedi Farah ◽  
Quentin Charley ◽  
...  
Keyword(s):  
Round Window ◽  
Flair Sequence ◽  
3D Flair

scholarly journals Audiovestibular Phenotypes and Advanced Magnetic Resonance Imaging Features of Cochlin Gene Mutation Carriers

2019 ◽  
Vol 24 (4) ◽  
pp. 166-173
Author(s):  
Giorgio Conte ◽  
Francesco Lo Russo ◽  
Luca Caschera ◽  
Diego Zanetti ◽  
Pierangela Castorina ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Endolymphatic Hydrops ◽  
Heterozygous Mutation ◽  
Main Role ◽  
Imaging Features ◽  
Resonance Imaging ◽  
Flair Sequence ◽  
Factor C ◽  
3D Flair

Objective: To describe clinical and imaging findings in a group of patients affected by nonsyndromic deafness A9 (DFNA9), using advanced magnetic resonance imaging (MRI) with 3-dimensional (3D) fluid-attenuated inversion recovery (FLAIR) sequence. Method: A retrospective case review was conducted in a tertiary referral center in Italy. Four sequential adult DFNA9-affected patients, who had undergone MRI at our Department between January 2017 and June 2018, were enrolled (male = 2, female = 2; median age: 65.6 years; 8 diseased ears analyzed). Three patients were relatives; the fourth was unrelated. The main outcome measures – age, sex, records of audiological and vestibular testing, genetic assessment, MRI findings – were analyzed. Results: All subjects suffered from bilateral progressive sensorineural hearing loss, more severely at the high frequencies and with a typical clinical pattern of bilateral chronic degenerative cochleovestibular deficit. Aural fullness was reported at the onset of the disease. All patients revealed a pathogenic heterozygous mutation in the Limulus factor C, Coch-5b2 and Lgl1 domain of cochlin. None of the patients showed a significant vestibular and cochlear endolymphatic hydrops at MRI, while high bilateral contrast enhancement on 4-h delayed postcontrast 3D FLAIR sequence was observed in all ears. Conclusions: Increased perilymph enhancement on 4-h delayed postcontrast 3D FLAIR sequence is the common imaging feature of DFNA9 ears, suggesting that blood-labyrinthine barrier breakdown may play the main role in the pathophysiology of this disease. Significant hydrops has been excluded by MRI. This finding might be clinically useful in differentiating DFNA9 disease from other pathologies with similar clinical findings like Ménière’s disease.

Three - dimensional fluid attenuated inversion recovery sequence on 3 tesla magnetic resonace imaging in cranial nerve pathologies: Two case reports

2021 ◽  
Author(s):  
Thuyet Dinh Van
Keyword(s):  
Cranial Nerve ◽  
Case Reports ◽  
Three Dimensional ◽  
Inversion Recovery ◽  
Inversion Recovery Sequence ◽  
Recovery Sequence ◽  
Flair Sequence ◽  
Fluid Attenuated Inversion Recovery ◽  
Fluid Pulsation ◽  
3D Flair

Three - dimensional fluid attenuated inversion recovery sequence (3D-FLAIR) was introduced as a practical sequence which helps to reduce the cerebrospinal fluid pulsation and flow artefacts of conventional 2D acquisition and brings contiguous slices, ability in reformatting in variable planes which are typical features of 3D acquisition. 3D - FLAIR has been applied on assessing several neurologic pathologies. In this article, we introduce the application of 3D - FLAIR sequence without contrast enhancement on detecting abnormalities of cranial nerve pathology by presenting two cases, acute vestibular neuritis and facial nerve palsy. We suggest that 3D - FLAIR is the relatively useful sequence in detecting cranial nerve pathologies.

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