scholarly journals Convolutional Neural Network–Based Automated Segmentation of the Spinal Cord and Contusion Injury: Deep Learning Biomarker Correlates of Motor Impairment in Acute Spinal Cord Injury

2019 ◽  
Author(s):  
D.B. McCoy ◽  
S.M. Dupont ◽  
C. Gros ◽  
J. Cohen-Adad ◽  
R.J. Huie ◽  
...  
Keyword(s):  
Neural Network ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Deep Learning ◽  
Convolutional Neural Network ◽  
Motor Impairment ◽  
Acute Spinal Cord Injury ◽  
Automated Segmentation ◽  
Cord Injury ◽  
Contusion Injury

Why Do We Not Have a Drug to Treat Acute Spinal Cord Injury?

Neurotrauma ◽  
2018 ◽  
pp. 411-422
Author(s):  
James W. Geddes
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Acute Spinal Cord Injury ◽  
Secondary Injury ◽  
Functional Deficits ◽  
Injury Mechanisms ◽  
Cord Injury ◽  
Contusion Injury ◽  
Weight Drop ◽  
Intraspinal Hemorrhage

More than 100 years ago, Alfred Reginald Allen developed the weight-drop model of graded, reproducible contusion injury to the dorsal spinal cord. Allen also introduced the concept of secondary injury mechanisms, hypothesizing that hemorrhage and elevated intraspinal pressure contribute to the destruction of the spinal cord and functional deficits. Our understanding of the secondary injury cascade has advanced tremendously over the past 100 years, with numerous therapeutic targets identified. Yet we lack an effective drug treatment for acute spinal cord injury. Reasons for the failure to translate promising preclinical findings to successful clinical trials include concerns regarding the quality of preclinical studies, including possible bias and inappropriate statistical analysis; questions regarding the suitability of animal models; and the complexity of secondary mechanisms following spinal cord injury. Perhaps, however, we have overlooked the targets identified by Allen, namely the intraspinal hemorrhage and elevations in intraspinal pressure.

Vasopressor support in managing acute spinal cord injury: current knowledge

2019 ◽  
Vol 63 (3) ◽  
Author(s):  
John K. Yue ◽  
Rachel E. Tsolinas ◽  
John F. Burke ◽  
Hansen Deng ◽  
Pavan S. Upadhyayula ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Current Knowledge ◽  
Acute Spinal Cord Injury ◽  
Vasopressor Support ◽  
Cord Injury

scholarly journals Role of melatonin in the dynamics of acute spinal cord injury in rats

2021 ◽  
Author(s):  
Jiaqi Bi ◽  
Jianxiong Shen ◽  
Chong Chen ◽  
Zheng Li ◽  
Haining Tan ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Acute Spinal Cord Injury ◽  
Cord Injury
Sign in / Sign up

Export Citation Format

Share Document