scholarly journals Morphologic Evolution and Coordinated Development of the Fetal Lateral Ventricles in the Second and Third Trimesters

2019 ◽  
Author(s):  
Z. Li ◽  
F. Xu ◽  
Z. Zhang ◽  
X. Lin ◽  
G. Teng ◽  
...  
Keyword(s):  
Coordinated Development ◽  
Lateral Ventricles ◽  
Morphologic Evolution

CT and IVIRI Findings of Neuroepithelial Cysts in the Lateral Ventricles

1995 ◽  
Vol 32 (1) ◽  
pp. 51
Author(s):  
Young Min Han ◽  
Ki Chul Choi ◽  
Chong Soo Kim ◽  
See Sung Choi ◽  
Gyung Ho Chung ◽  
...  
Keyword(s):  
Lateral Ventricles ◽  
Neuroepithelial Cysts

Intracisternal BioGlue injection in the fetal lamb: a novel model for creation of obstructive congenital hydrocephalus without additional chemically induced neuroinflammation

2019 ◽  
Vol 24 (6) ◽  
pp. 652-662 ◽  
Author(s):  
Marc Oria ◽  
Soner Duru ◽  
Federico Scorletti ◽  
Fernando Vuletin ◽  
Jose L. Encinas ◽  
...  
Keyword(s):  
Calcium Binding ◽  
Repeated Measures ◽  
Obstructive Hydrocephalus ◽  
Critical Threshold ◽  
Control Group ◽  
Chronic Obstructive ◽  
Fetal Sheep ◽  
Cisterna Magna ◽  
Lateral Ventricles ◽  
Fetal Lamb

OBJECTIVEThe authors hypothesized that new agents such as BioGlue would be as efficacious as kaolin in the induction of hydrocephalus in fetal sheep.METHODSThis study was performed in 34 fetal lambs randomly divided into 2 studies. In the first study, fetuses received kaolin, BioGlue (2.0 mL), or Onyx injected into the cisterna magna, or no injection (control group) between E85 and E90. In the second study, fetuses received 2.0-mL or 2.5-mL injections of BioGlue into the cisterna magna between E85 and E90. Fetuses were monitored using ultrasound to assess lateral ventricle size and progression of hydrocephalus. The fetuses were delivered (E120–E125) and euthanized for histological analysis. Selected brain sections were stained for ionized calcium binding adaptor 1 (Iba1) and glial fibrillary acidic protein (GFAP) to assess the presence and activation of microglia and astroglia, respectively. Statistical comparisons were performed with Student’s t-test for 2 determinations and ANOVA 1-way and 2-way repeated measures for multiple determinations.RESULTSAt 30 days after injection, the lateral ventricles were larger in all 3 groups that had undergone injection than in controls (mean diameter in controls 3.76 ± 0.05 mm, n = 5). However, dilatation was greater in the fetuses injected with 2 mL of BioGlue (11.34 ± 4.76 mm, n = 11) than in those injected with kaolin (6.4 ± 0.98 mm, n = 7) or Onyx (5.7 ± 0.31 mm, n = 6) (ANOVA, *p ≤ 0.0001). Fetuses injected with 2.0 mL or 2.5 mL of BioGlue showed the same ventricle dilatation but it appeared earlier (at 10 days postinjection) in those injected with 2.5 mL. The critical threshold of ventricle dilatation was 0.1 for all the groups, and only the BioGlue 2.0 mL and BioGlue 2.5 mL groups exceeded this critical value (at 30 days and 18 days after injection, respectively) (ANOVA, *p ≤ 0.0001). Moderate to severe hydrocephalus with corpus callosum disruption was observed in all experimental groups. All experimental groups showed ventriculomegaly with significant microgliosis and astrogliosis in the subventricular zone around the lateral ventricles. Only kaolin resulted in significant microgliosis in the fourth ventricle area (ANOVA, *p ≤ 0.005).CONCLUSIONSThe results of these studies demonstrate that BioGlue is more effective than Onyx or kaolin for inducing hydrocephalus in the fetal lamb and results in a volume-related response by obstructive space-occupancy without local neuroinflammatory reaction. This novel use of BioGlue generates a model with potential for new insights into hydrocephalus pathology and the development of therapeutics in obstructive hydrocephalus. In addition, this model allows for the study of acute and chronic obstructive hydrocephalus by using different BioGlue volumes for intracisternal injection.

Replication of Quantum Computing towards an Unconventional Environment using QuIDE

2019 ◽  
Vol 8 (4) ◽  
pp. 9461-9464
Keyword(s):  
Quantum Computer ◽  
Source Code ◽  
Circuit Diagram ◽  
Quantum Computers ◽  
Coordinated Development ◽  
Development Environment ◽  
Integrated Development ◽  
Complexity Of Algorithms ◽  
Performance Results ◽  
Exponential Complexity

Current quantum computer simulation strategies are inefficient in simulation and their realizations are also failed to minimize those impacts of the exponential complexity for simulated quantum computations. We proposed a Quantum computer simulator model in this paper which is a coordinated Development Environment – QuIDE (Quantum Integrated Development Environment) to support the improvement of algorithm for future quantum computers. The development environment provides the circuit diagram of graphical building and flexibility of source code. Analyze the complexity of algorithms shows the performance results of the simulator and used for simulation as well as result of its deployment during simulation

MORPHOLOGIC EVOLUTION AND DISPARITY IN CAMBRIAN ECHINODERMS

2016 ◽  
Author(s):  
Nicholas S. Smith ◽  
◽  
Samuel Zamora ◽  
Imran Alexander Rahman ◽  
Bradley Deline
Keyword(s):  
Morphologic Evolution
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